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C1s complement C1s [ Cavia porcellus (domestic guinea pig) ]

Gene ID: 100722315, updated on 8-Mar-2024

Summary

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Gene symbol
C1s
Gene description
complement C1s
See related
Ensembl:ENSCPOG00000008905
Gene type
protein coding
RefSeq status
MODEL
Organism
Cavia porcellus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae; Cavia
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current mCavPor4.1 (GCF_034190915.1) Unplaced Scaffold NW_026947510.1 (310048..320613, complement)
103 previous assembly Cavpor3.0 (GCF_000151735.1) Unplaced Scaffold NT_176312.1 (228844..239434, complement)

NW_026947510.1Genomic Context describing neighboring genes Neighboring gene complement C1r subcomponent like Neighboring gene complement C1r Neighboring gene uncharacterized LOC134473456 Neighboring gene lysophosphatidylcholine acyltransferase 3 Neighboring gene EMG1 N1-specific pseudouridine methyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in complement activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
complement C1s subcomponent

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_034190915.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mCavPor4.1

Genomic

  1. NW_026947510.1 Reference mCavPor4.1

    Range
    310048..320613 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_013145104.3 → XP_013000558.1  complement C1s subcomponent

    See identical proteins and their annotated locations for XP_013000558.1

    UniProtKB/TrEMBL
    H0VDE9
    Related
    ENSCPOP00000026834.1
    Conserved Domains (6) summary
    cd00033
    Location:300 → 361
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00020
    Location:443 → 681
    Tryp_SPc; Trypsin-like serine protease
    cd00041
    Location:24 → 135
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00190
    Location:444 → 684
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00431
    Location:181 → 293
    CUB; CUB domain
    pfam14670
    Location:149 → 177
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  2. XM_003463234.5 → XP_003463282.1  complement C1s subcomponent

    See identical proteins and their annotated locations for XP_003463282.1

    UniProtKB/TrEMBL
    H0VDE9
    Conserved Domains (6) summary
    cd00033
    Location:300 → 361
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00020
    Location:443 → 681
    Tryp_SPc; Trypsin-like serine protease
    cd00041
    Location:24 → 135
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00190
    Location:444 → 684
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00431
    Location:181 → 293
    CUB; CUB domain
    pfam14670
    Location:149 → 177
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  3. XM_005000637.4 → XP_005000694.1  complement C1s subcomponent

    See identical proteins and their annotated locations for XP_005000694.1

    UniProtKB/TrEMBL
    H0VDE9
    Related
    ENSCPOP00000007999.3
    Conserved Domains (6) summary
    cd00033
    Location:300 → 361
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00020
    Location:443 → 681
    Tryp_SPc; Trypsin-like serine protease
    cd00041
    Location:24 → 135
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00190
    Location:444 → 684
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00431
    Location:181 → 293
    CUB; CUB domain
    pfam14670
    Location:149 → 177
    FXa_inhibition; Coagulation Factor Xa inhibitory site
Nucleotide Protein
Heading Accession and Version

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