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DPP3 dipeptidyl peptidase 3 [ Homo sapiens (human) ]

Gene ID: 10072, updated on 8-May-2016
Official Symbol
DPP3provided by HGNC
Official Full Name
dipeptidyl peptidase 3provided by HGNC
Primary source
HGNC:HGNC:3008
See related
Ensembl:ENSG00000254986 HPRD:06012; MIM:606818; Vega:OTTHUMG00000167143
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DPPIII
Summary
This gene encodes a protein that is a member of the M49 family of metallopeptidases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Increased activity of this protein is associated with endometrial and ovarian cancers. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2012]
Orthologs
Location:
11q13.2
Exon count:
18
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (66480013..66509659)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (66247484..66277130)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene chromosome 5 open reading frame 63 pseudogene Neighboring gene uncharacterized LOC105369206 Neighboring gene uncharacterized LOC101928069 Neighboring gene pellino E3 ubiquitin protein ligase family member 3 Neighboring gene uncharacterized LOC105379405 Neighboring gene Bardet-Biedl syndrome 1 Neighboring gene zinc finger DHHC-type containing 24 Neighboring gene actinin alpha 3 (gene/pseudogene)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ11387, FLJ22331

Gene Ontology Provided by GOA

Function Evidence Code Pubs
dipeptidyl-peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
Preferred Names
dipeptidyl peptidase 3
Names
DPP III
dipeptidyl aminopeptidase III
dipeptidyl arylamidase III
dipeptidyl peptidase III
enkephalinase B
NP_001243599.1
NP_005691.2
NP_569710.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032068.1 RefSeqGene

    Range
    4605..34251
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001256670.1NP_001243599.1  dipeptidyl peptidase 3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame coding exon compared to variant 1. This results in a shorter isoform (2) missing an internal protein segment compared to isoform 1.
    Source sequence(s)
    AJ271216, AK297199, AK315478, CD366941, DC325853, DC403406, DC407885
    Consensus CDS
    CCDS58147.1
    UniProtKB/Swiss-Prot
    Q9NY33
    Related
    ENSP00000436941, OTTHUMP00000235332, ENST00000530165, OTTHUMT00000393428
    Conserved Domains (1) summary
    pfam03571
    Location:113675
    Peptidase_M49; Peptidase family M49
  2. NM_005700.4NP_005691.2  dipeptidyl peptidase 3 isoform 1

    See identical proteins and their annotated locations for NP_005691.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AJ271216, AK315478, CD366941, DC325853, DC403406, DC407885
    Consensus CDS
    CCDS8141.1
    UniProtKB/Swiss-Prot
    Q9NY33
    Related
    ENSP00000435284, OTTHUMP00000235328, ENST00000532677, OTTHUMT00000393423
    Conserved Domains (1) summary
    pfam03571
    Location:143705
    Peptidase_M49; Peptidase family M49
  3. NM_130443.3NP_569710.2  dipeptidyl peptidase 3 isoform 1

    See identical proteins and their annotated locations for NP_569710.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate acceptor splice site at a 5' non-coding exon compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AL833475, BC024271, CD366941, DC325853, DC403406, DC407885
    Consensus CDS
    CCDS8141.1
    UniProtKB/Swiss-Prot
    Q9NY33
    UniProtKB/TrEMBL
    Q5JPB8
    Related
    ENSP00000440502, OTTHUMP00000235329, ENST00000541961, OTTHUMT00000393424
    Conserved Domains (1) summary
    pfam03571
    Location:143705
    Peptidase_M49; Peptidase family M49

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

    Range
    66480013..66509659
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    66131228..66160856
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)