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wwox WW domain containing oxidoreductase [ Oreochromis niloticus (Nile tilapia) ]

Gene ID: 100698293, updated on 8-Mar-2024

Summary

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Gene symbol
wwox
Gene description
WW domain containing oxidoreductase
See related
Ensembl:ENSONIG00000035342
Gene type
protein coding
RefSeq status
MODEL
Organism
Oreochromis niloticus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; Pseudocrenilabrinae; Oreochromini; Oreochromis
Expression
Ubiquitous expression in ovary (RPKM 4.3), testis (RPKM 4.3) and 9 other tissues See more
Orthologs
human zebrafish all
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Genomic context

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Location:
chromosome: LG7
Exon count:
12
Annotation release Status Assembly LG Location
104 current O_niloticus_UMD_NMBU (GCF_001858045.2) LG7 NC_031972.2 (56052171..56179975, complement)
103 previous assembly ASM185804v2 (GCF_001858045.1) LG7 NC_031972.1 (40984447..41112955)

Linkage Group LG7 - NC_031972.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102077461 Neighboring gene transcription factor Maf Neighboring gene uncharacterized LOC112841771 Neighboring gene nuclear factor of activated T cells 5a Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Oreochromis niloticus Transcriptome or Gene expression
  • Description: Oreochromis niloticus (Nile Tilapia) RNA sequencing from multiple tissues.
  • BioProject: PRJNA78915
  • Analysis date: Fri Dec 29 00:23:36 2017

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in hippo signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
WW domain-containing oxidoreductase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Oreochromis niloticus Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference O_niloticus_UMD_NMBU Primary Assembly

Genomic

  1. NC_031972.2 Reference O_niloticus_UMD_NMBU Primary Assembly

    Range
    56052171..56179975 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_013268640.3 → XP_013124094.1  WW domain-containing oxidoreductase isoform X1

    UniProtKB/TrEMBL
    A0A669CSW0, A0A669DQU8
    Related
    ENSONIP00000061758.1, ENSONIT00000063409.1
    Conserved Domains (4) summary
    cd09809
    Location:167 → 450
    human_WWOX_like_SDR_c-like; human WWOX (WW domain-containing oxidoreductase)-like, classical (c)-like SDRs
    PRK06196
    Location:154 → 451
    PRK06196; oxidoreductase; Provisional
    cd00201
    Location:106 → 135
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:64 → 93
    WW; WW domain

  2. XM_019361516.2 → XP_019217061.1  WW domain-containing oxidoreductase isoform X2

    UniProtKB/TrEMBL
    A0A669CSW0

  3. XM_005470884.4 → XP_005470941.1  WW domain-containing oxidoreductase isoform X3

    UniProtKB/TrEMBL
    A0A669CSW0
    Conserved Domains (4) summary
    cd00201
    Location:106 → 135
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00106
    Location:168 → 369
    adh_short; short chain dehydrogenase
    pfam00397
    Location:64 → 93
    WW; WW domain
    cl21454
    Location:167 → 395
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  4. XM_025909117.1 → XP_025764902.1  WW domain-containing oxidoreductase isoform X4

    Conserved Domains (2) summary
    pfam00397
    Location:64 → 93
    WW; WW domain
    cl25409
    Location:167 → 222
    SDR; Short-chain dehydrogenases/reductases (SDR)
Nucleotide Protein
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