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Tlr4 toll like receptor 4 [ Cricetulus griseus (Chinese hamster) ]

Gene ID: 100689329, updated on 8-Mar-2024

Summary

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Gene symbol
Tlr4
Gene description
toll like receptor 4
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Cricetulus griseus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Cricetinae; Cricetulus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
4
Annotation release Status Assembly Chr Location
104 current CriGri_1.0 (GCF_000223135.1) Unplaced Scaffold NW_003614635.1 (507684..519285, complement)
104 current CriGri-PICRH-1.0 (GCF_003668045.3) 2 NC_048595.1 (79135574..79147112, complement)

NW_003614635.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain-containing protein 71-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide. Lien E, et al. J Clin Invest, 2000 Feb. PMID 10683379, Free PMC Article
  2. Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing. Becker J, et al. J Biotechnol, 2011 Dec 10. PMID 21945585

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables lipopolysaccharide binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables lipopolysaccharide immune receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response to Gram-negative bacterium IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in toll-like receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
toll-like receptor 4
NP_001233691.1
XP_007647864.1
XP_035316117.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001246762.1 → NP_001233691.1  toll-like receptor 4 precursor

    See identical proteins and their annotated locations for NP_001233691.1

    Status: PROVISIONAL

    Source sequence(s)
    AF153676
    UniProtKB/Swiss-Prot
    Q9WV82
    UniProtKB/TrEMBL
    G3I192
    Conserved Domains (3) summary
    smart00255
    Location:672 → 813
    TIR; Toll - interleukin 1 - resistance
    COG4886
    Location:23 → 191
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:55 → 78
    LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: Cricetulus griseus Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference CriGri_1.0 Primary Assembly

Genomic

  1. NW_003614635.1 Reference CriGri_1.0 Primary Assembly

    Range
    507684..519285 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_035460226.1 → XP_035316117.1  toll-like receptor 4 isoform X1

    Conserved Domains (3) summary
    smart00255
    Location:643 → 784
    TIR; Toll - interleukin 1 - resistance
    COG4886
    Location:2 → 162
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:26 → 49
    LRR_RI; leucine-rich repeat [structural motif]

  2. XM_007649674.4 → XP_007647864.1  toll-like receptor 4 isoform X2

    Conserved Domains (6) summary
    smart00082
    Location:498 → 541
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:594 → 735
    TIR; Toll - interleukin 1 - resistance
    cd00116
    Location:291 → 483
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:321 → 343
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:73 → 111
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:24 → 108
    LRR_8; Leucine rich repeat

Alternate CriGri-PICRH-1.0

Genomic

  1. NC_048595.1 Alternate CriGri-PICRH-1.0

    Range
    79135574..79147112 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WV82.1 GenPept UniProtKB/Swiss-Prot:Q9WV82

Gene LinkOut

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