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PRSS12 serine protease 12 [ Canis lupus familiaris (dog) ]

Gene ID: 100687821, updated on 8-Mar-2024

Summary

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Official Symbol
PRSS12provided by VGNC
Official Full Name
serine protease 12provided by VGNC
Primary source
VGNC:VGNC:45062
See related
Ensembl:ENSCAFG00845029625
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See PRSS12 in Genome Data Viewer
Location:
chromosome: 32
Exon count:
13
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 32 NC_051836.1 (37730129..37808285, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 32 NC_006614.4 (4487268..4564942)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 32 NC_049253.1 (2249097..2327432)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 32 NC_049292.1 (37753268..37831362, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 32 NC_049773.1 (37476304..37554549, complement)

Chromosome 32 - NC_051836.1Genomic Context describing neighboring genes Neighboring gene N-deacetylase and N-sulfotransferase 3 Neighboring gene uncharacterized LOC102152366 Neighboring gene small nucleolar RNA SNORA24 Neighboring gene histidine triad nucleotide-binding protein 1-like Neighboring gene U4 spliceosomal RNA Neighboring gene methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
neurotrypsin
Names
protease, serine 12

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051836.1 Reference ROS_Cfam_1.0

    Range
    37730129..37808285 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038444508.1 → XP_038300436.1  neurotrypsin

    UniProtKB/TrEMBL
    A0A8C0KVA8, A0A8I3Q451, A0A8P0SPZ7
    Related
    ENSCAFP00845041164.1, ENSCAFT00845052465.1
    Conserved Domains (3) summary
    smart00202
    Location:470 → 569
    SR; Scavenger receptor Cys-rich
    cd00190
    Location:601 → 842
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    cl00100
    Location:62 → 135
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049292.1 Alternate UMICH_Zoey_3.1

    Range
    37753268..37831362 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038518905.1 → XP_038374833.1  neurotrypsin

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049773.1 Alternate UNSW_CanFamBas_1.0

    Range
    37476304..37554549 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038646844.1 → XP_038502772.1  neurotrypsin

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049253.1 Alternate UU_Cfam_GSD_1.0

    Range
    2249097..2327432
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038581776.1 → XP_038437704.1  neurotrypsin

    UniProtKB/TrEMBL
    A0A8C0KVA8, A0A8C0NPC0

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006614.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    4487268..4564942
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003434008.5 → XP_003434056.2  neurotrypsin

    UniProtKB/TrEMBL
    A0A8C0KVA8, A0A8I3Q451, A0A8P0SPZ7
    Conserved Domains (3) summary
    smart00202
    Location:470 → 569
    SR; Scavenger receptor Cys-rich
    cd00190
    Location:601 → 842
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    cl00100
    Location:62 → 135
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
Nucleotide Protein
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