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LOC100658798 probable ATP-dependent RNA helicase DDX56 [ Loxodonta africana (African savanna elephant) ]

Gene ID: 100658798, updated on 11-Apr-2024

Summary

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Gene symbol
LOC100658798
Gene description
probable ATP-dependent RNA helicase DDX56
See related
EnsemblRapid:ENSLAFG00000018200 EnsemblRapid:ENSLAFG00000018206
Gene type
protein coding
RefSeq status
MODEL
Organism
Loxodonta africana
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta
Also known as
DDX56; NPC1L1
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Genomic context

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Location:
chromosome: 8
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_04 current mLoxAfr1.hap2 (GCF_030014295.1) 8 NC_087349.1 (120111495..120154846)
102 previous assembly Loxafr3.0 (GCF_000001905.1) Unplaced Scaffold NW_003573483.1 (12613784..12654346, complement)

Chromosome 8 - NC_087349.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene oxoglutarate dehydrogenase Neighboring gene transmembrane p24 trafficking protein 4 Neighboring gene transfer RNA leucine (anticodon UAA) Neighboring gene NudC domain containing 3 Neighboring gene microtubule-associated protein RP/EB family member 1-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cholesterol binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables lipid transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cholesterol homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intestinal cholesterol absorption IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
NPC1-like intracellular cholesterol transporter 1; probable ATP-dependent RNA helicase DDX56
Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 56
DEAD-box helicase 56
NPC1 (Niemann-Pick disease, type C1, gene)-like 1
NPC1 like intracellular cholesterol transporter 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_030014295.1-RS_2024_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mLoxAfr1.hap2

Genomic

  1. NC_087349.1 Reference mLoxAfr1.hap2

    Range
    120111495..120154846
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_064290264.1 → XP_064146334.1  NPC1-like intracellular cholesterol transporter 1 isoform X2

  2. XM_064290263.1 → XP_064146333.1  NPC1-like intracellular cholesterol transporter 1 isoform X1

  3. XM_064290265.1 → XP_064146335.1  NPC1-like intracellular cholesterol transporter 1 isoform X3

  4. XM_064290266.1 → XP_064146336.1  NPC1-like intracellular cholesterol transporter 1 isoform X4

  5. XM_023558593.2 → XP_023414361.2  NPC1-like intracellular cholesterol transporter 1 isoform X5

  6. XM_064290267.1 → XP_064146337.1  NPC1-like intracellular cholesterol transporter 1 isoform X6

  7. XM_023558595.2 → XP_023414363.1  NPC1-like intracellular cholesterol transporter 1 isoform X7

    Conserved Domains (2) summary
    COG0513
    Location:8 → 515
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cl25655
    Location:536 → 1230
    Patched; Patched family

  8. XM_003418575.4 → XP_003418623.1  probable ATP-dependent RNA helicase DDX56 isoform X8

    UniProtKB/TrEMBL
    G3TKB7
    Related
    ENSLAFP00000015255.3, ENSLAFT00000018209.3
    Conserved Domains (3) summary
    COG0513
    Location:8 → 515
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    pfam00271
    Location:256 → 378
    Helicase_C; Helicase conserved C-terminal domain
    cl21455
    Location:8 → 218
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  9. XM_064290268.1 → XP_064146338.1  NPC1-like intracellular cholesterol transporter 1 isoform X9

    Related
    ENSLAFP00000015250.4, ENSLAFT00000018202.4
Nucleotide Protein
Heading Accession and Version

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