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NF2 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor [ Nomascus leucogenys (northern white-cheeked gibbon) ]

Gene ID: 100599082, updated on 8-Mar-2024

Summary

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Gene symbol
NF2
Gene description
NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor
See related
EnsemblRapid:ENSNLEG00000003205
Gene type
protein coding
RefSeq status
MODEL
Organism
Nomascus leucogenys
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae; Nomascus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 7b
Exon count:
17
Annotation release Status Assembly Chr Location
103 current Asia_NLE_v1 (GCF_006542625.1) 7b NC_044387.1 (56911039..57002225)
102 previous assembly Nleu_3.0 (GCF_000146795.2) 7b NC_019822.1 (59705116..59792920)

Chromosome 7b - NC_044387.1Genomic Context describing neighboring genes Neighboring gene THO complex subunit 5 Neighboring gene nipsnap homolog 1 Neighboring gene calcium binding protein 7 Neighboring gene zinc finger matrin-type 5 Neighboring gene cytochrome b-c1 complex subunit 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cell adhesion molecule binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of early endosome to late endosome transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of protein localization to early endosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of gliogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of organelle assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in apical part of cell IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in filopodium IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
merlin
Names
neurofibromin 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Nomascus leucogenys Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Asia_NLE_v1 Primary Assembly

Genomic

  1. NC_044387.1 Reference Asia_NLE_v1 Primary Assembly

    Range
    56911039..57002225
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012507938.2 → XP_012363392.1  merlin isoform X2

    See identical proteins and their annotated locations for XP_012363392.1

    UniProtKB/TrEMBL
    A0A2I3FXA5, A0A2I3GW09
    Related
    ENSNLEP00000035548.2, ENSNLET00000054376.2
    Conserved Domains (4) summary
    PLN03086
    Location:307 → 367
    PLN03086; PRLI-interacting factor K; Provisional
    smart00295
    Location:23 → 222
    B41; Band 4.1 homologues
    cd13194
    Location:216 → 312
    FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
    pfam00769
    Location:347 → 579
    ERM; Ezrin/radixin/moesin family

  2. XM_030816067.1 → XP_030671927.1  merlin isoform X2

    UniProtKB/TrEMBL
    A0A2I3FXA5, A0A2I3GW09
    Conserved Domains (4) summary
    PLN03086
    Location:307 → 367
    PLN03086; PRLI-interacting factor K; Provisional
    smart00295
    Location:23 → 222
    B41; Band 4.1 homologues
    cd13194
    Location:216 → 312
    FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
    pfam00769
    Location:347 → 579
    ERM; Ezrin/radixin/moesin family

  3. XM_003258051.4 → XP_003258099.1  merlin isoform X1

    UniProtKB/TrEMBL
    A0A2I3GMW2, G1QT29
    Related
    ENSNLEP00000004097.1, ENSNLET00000004299.4
    Conserved Domains (4) summary
    PLN03086
    Location:307 → 367
    PLN03086; PRLI-interacting factor K; Provisional
    smart00295
    Location:23 → 222
    B41; Band 4.1 homologues
    cd13194
    Location:216 → 312
    FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
    pfam00769
    Location:347 → 595
    ERM; Ezrin/radixin/moesin family
Nucleotide Protein
Heading Accession and Version

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