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DUOX2 dual oxidase 2 [ Nomascus leucogenys (northern white-cheeked gibbon) ]

Gene ID: 100595406, updated on 8-Mar-2024

Summary

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Gene symbol
DUOX2
Gene description
dual oxidase 2
See related
EnsemblRapid:ENSNLEG00000005749
Gene type
protein coding
RefSeq status
MODEL
Organism
Nomascus leucogenys
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae; Nomascus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 6
Exon count:
34
Annotation release Status Assembly Chr Location
103 current Asia_NLE_v1 (GCF_006542625.1) 6 NC_044386.1 (56264666..56285932)
102 previous assembly Nleu_3.0 (GCF_000146795.2) 6 NC_019821.1 (55564963..55586398)

Chromosome 6 - NC_044386.1Genomic Context describing neighboring genes Neighboring gene dual oxidase 1 Neighboring gene dual oxidase maturation factor 1 Neighboring gene dual oxidase maturation factor 2 Neighboring gene sorbitol dehydrogenase Neighboring gene U1 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables peroxidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables superoxide-generating NAD(P)H oxidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in superoxide anion generation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of NADPH oxidase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
dual oxidase 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Nomascus leucogenys Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Asia_NLE_v1 Primary Assembly

Genomic

  1. NC_044386.1 Reference Asia_NLE_v1 Primary Assembly

    Range
    56264666..56285932
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012507386.2 → XP_012362840.2  dual oxidase 2 isoform X2

    UniProtKB/TrEMBL
    G1R1E3

  2. XM_003266859.2 → XP_003266907.2  dual oxidase 2 isoform X1

    UniProtKB/TrEMBL
    G1R1E3
    Related
    ENSNLEP00000007015.3, ENSNLET00000007363.3
    Conserved Domains (5) summary
    cd06186
    Location:1278 → 1552
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    cd09820
    Location:38 → 594
    dual_peroxidase_like; Dual oxidase and related animal heme peroxidases
    cd00051
    Location:824 → 885
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam01794
    Location:1092 → 1236
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam13499
    Location:764 → 848
    EF-hand_7; EF-hand domain pair
Nucleotide Protein
Heading Accession and Version

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