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FARSB phenylalanyl-tRNA synthetase beta subunit [ Homo sapiens (human) ]

Gene ID: 10056, updated on 26-May-2016
Official Symbol
FARSBprovided by HGNC
Official Full Name
phenylalanyl-tRNA synthetase beta subunitprovided by HGNC
Primary source
HGNC:HGNC:17800
See related
Ensembl:ENSG00000116120 HPRD:09947; MIM:609690
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FRSB; PheHB; PheRS; FARSLB; HSPC173
Summary
This gene encodes a highly conserved enzyme that belongs to the aminoacyl-tRNA synthetase class IIc subfamily. This enzyme comprises the regulatory beta subunits that form a tetramer with two catalytic alpha subunits. In the presence of ATP, this tetramer is responsible for attaching L-phenylalanine to the terminal adenosine of the appropriate tRNA. A pseudogene located on chromosome 10 has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Orthologs
Location:
2q36.1
Exon count:
19
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (222571443..222656355, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (223436162..223520827, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene sphingosine-1-phosphate phosphatase 2 Neighboring gene Nanog homeobox pseudogene 2 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 49 Neighboring gene uncharacterized LOC105373902 Neighboring gene tripartite motif containing 60 pseudogene Neighboring gene related RAS viral (r-ras) oncogene homolog 2 pseudogene Neighboring gene monoacylglycerol O-acyltransferase 1 Neighboring gene ribosomal protein L31 pseudogene 17

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
phenylalanine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
phenylalanyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
 
tRNA aminoacylation for protein translation TAS
Traceable Author Statement
more info
 
translation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
phenylalanine-tRNA ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
phenylalanine--tRNA ligase beta subunit
Names
phenylalanine tRNA ligase 1, beta, cytoplasmic
phenylalanine--tRNA ligase beta chain
phenylalanine-tRNA ligase beta chain
phenylalanine-tRNA synthetase-like, beta subunit
phenylalanyl-tRNA synthetase beta chain
phenylalanyl-tRNA synthetase beta-subunit
phenylalanyl-tRNA synthetase, beta subunit
phenylalanyl-tRNA synthetase-like, beta subunit
NP_005678.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005687.4NP_005678.3  phenylalanine--tRNA ligase beta subunit

    See identical proteins and their annotated locations for NP_005678.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the functional protein.
    Source sequence(s)
    AC097461, AC104772, AF042346, BG721840
    Consensus CDS
    CCDS2454.1
    UniProtKB/Swiss-Prot
    Q9NSD9
    Related
    ENSP00000281828, OTTHUMP00000164205, ENST00000281828, OTTHUMT00000256855
    Conserved Domains (4) summary
    smart00874
    Location:305374
    B5; tRNA synthetase B5 domain
    smart00873
    Location:118279
    B3_4; B3/4 domain
    PLN02265
    Location:1589
    PLN02265; probable phenylalanyl-tRNA synthetase beta chain
    cd00769
    Location:392588
    PheRS_beta_core; Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an ...

RNA

  1. NR_130154.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC097461, AC104772, BC022273, BG721840

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

    Range
    222571443..222656355 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510466.1XP_011508768.1  

    See identical proteins and their annotated locations for XP_011508768.1

    UniProtKB/Swiss-Prot
    Q9NSD9
    Conserved Domains (3) summary
    smart00874
    Location:206275
    B5; tRNA synthetase B5 domain
    smart00873
    Location:19180
    B3_4; B3/4 domain
    cd00769
    Location:293489
    PheRS_beta_core; Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an ...
  2. XM_006712169.1XP_006712232.1  

    See identical proteins and their annotated locations for XP_006712232.1

    UniProtKB/Swiss-Prot
    Q9NSD9
    Conserved Domains (3) summary
    smart00874
    Location:206275
    B5; tRNA synthetase B5 domain
    smart00873
    Location:19180
    B3_4; B3/4 domain
    cd00769
    Location:293489
    PheRS_beta_core; Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an ...
  3. XM_006712170.1XP_006712233.1  

    See identical proteins and their annotated locations for XP_006712233.1

    UniProtKB/Swiss-Prot
    Q9NSD9
    Conserved Domains (3) summary
    smart00874
    Location:206275
    B5; tRNA synthetase B5 domain
    smart00873
    Location:19180
    B3_4; B3/4 domain
    cd00769
    Location:293489
    PheRS_beta_core; Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an ...

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    223442666..223527456 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)