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    POC1B-GALNT4 POC1B-GALNT4 readthrough [ Homo sapiens (human) ]

    Gene ID: 100528030, updated on 4-May-2013
    Official Symbol
    POC1B-GALNT4provided by HGNC
    Official Full Name
    POC1B-GALNT4 readthroughprovided by HGNC
    Primary source
    HGNC:42957
    See related
    Ensembl:ENSG00000259075; Vega:OTTHUMG00000171333
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This locus represents naturally occurring transcripts that splice the 5' exons of the POC1B (POC1 centriolar protein homolog B) gene on chromosome 12 to the GALNT4 (UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4) gene, which is located within a POC1B intron. Alternative splicing results in two transcript variants, one of which encodes a fusion isoform that shares sequence identity with the products of each individual gene. [provided by RefSeq, Dec 2010]
    Location :
    12q
    Sequence :
    Chromosome: 12; NC_000012.11 (89913189..89920039, complement)
    See POC1B-GALNT4 in Epigenomics, MapViewer

    Chromosome 12 - NC_000012.11Genomic Context describing neighboring genes Neighboring gene dual specificity phosphatase 6 Neighboring gene POC1 centriolar protein homolog B (Chlamydomonas) Neighboring gene centromere protein C 1 pseudogene 1 Neighboring gene UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4) Neighboring gene ATPase, Ca++ transporting, plasma membrane 1 Neighboring gene uncharacterized LOC338758

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Markers

    Clone Names

    • FLJ58458, DKFZp686D0362
    Preferred Names
    POC1B-GALNT4 protein
    Names
    POC1B-GALNT4 protein
    POC1B-GALNT4 fusion

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199781.1NP_001186710.1  POC1B-GALNT4 protein isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1), which shares sequence identity with the products of both the POC1B and GALNT4 genes.
      Source sequence(s)
      AC010201, AC025034, BX647258
      Consensus CDS
      CCDS55860.1
      UniProtKB/TrEMBL
      F8VUJ3
      Related
      ENSP00000447852, OTTHUMP00000245832, ENST00000548729, OTTHUMT00000413016
      Conserved Domains (4) summary
      cd00161
      Location:443573
      Blast Score: 236
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      COG0463
      Location:131256
      Blast Score: 140
      WcaA; Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]
      cd02510
      Location:135429
      Blast Score: 1179
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans.
      pfam00652
      Location:442571
      Blast Score: 268
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    2. NM_001199782.1NP_001186711.1  POC1B-GALNT4 protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate upstream start codon, differs in the 5' coding region, and uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) shares sequence identity with the GALNT4 gene product only, has a distinct N-terminus, and is shorter than isoform 1.
      Source sequence(s)
      AC010201, AC025034, AK297677, BX647258
      Consensus CDS
      CCDS55861.1
      UniProtKB/Swiss-Prot
      Q8N4A0
      Conserved Domains (3) summary
      cd00161
      Location:274404
      Blast Score: 231
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:273402
      Blast Score: 259
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
      cl11394
      Location:136260
      Blast Score: 547
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold.

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000012.11 Reference GRCh37.p10 Primary Assembly

      Range
      89913189..89920039, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000144.1 Alternate HuRef

      Range
      86979065..86985916, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018923.1 Alternate CHM1_1.0

      Range
      89760828..89767679, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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