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NSD2 nuclear receptor binding SET domain protein 2 [ Sus scrofa (pig) ]

Gene ID: 100515039, updated on 8-Mar-2024

Summary

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Official Symbol
NSD2provided by VGNC
Official Full Name
nuclear receptor binding SET domain protein 2provided by VGNC
Primary source
VGNC:VGNC:90905
See related
Ensembl:ENSSSCG00000008682
Gene type
protein coding
RefSeq status
MODEL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
WHSC1
Expression
Ubiquitous expression in spleen (RPKM 8.5), lung (RPKM 6.8) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See NSD2 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
23
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 8 NC_010450.4 (938832..1018032)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 8 NC_010450.3 (412141..514862)

Chromosome 8 - NC_010450.4Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor receptor 3 Neighboring gene leucine zipper and EF-hand containing transmembrane protein 1 Neighboring gene negative elongation factor complex member A Neighboring gene NELL2 interacting cell ontogeny regulator 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables histone H3K36 methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables methylated histone binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of chromatin IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
histone-lysine N-methyltransferase NSD2
Names
Wolf-Hirschhorn syndrome candidate 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010450.4 Reference Sscrofa11.1 Primary Assembly

    Range
    938832..1018032
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021100910.1 → XP_020956569.1  histone-lysine N-methyltransferase NSD2 isoform X1

    Conserved Domains (10) summary
    cd05837
    Location:198 → 317
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:915 → 1009
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    smart00570
    Location:1049 → 1099
    AWS; associated with SET domains
    smart00317
    Location:1100 → 1223
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cd00084
    Location:433 → 480
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cd15651
    Location:689 → 735
    PHD2_NSD2; PHD finger 2 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15654
    Location:736 → 789
    PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
    cl22851
    Location:1278 → 1320
    PHD_SF; PHD finger superfamily
    cl26267
    Location:543 → 683
    ING; Inhibitor of growth proteins N-terminal histone-binding
    cl26518
    Location:1282 → 1375
    EPL1; Enhancer of polycomb-like

  2. XM_021100913.1 → XP_020956572.1  histone-lysine N-methyltransferase NSD2 isoform X2

    UniProtKB/TrEMBL
    A0A480LQV4, A0A480PGJ7, A0A8D1H5F5
    Conserved Domains (9) summary
    cd05837
    Location:198 → 317
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:851 → 945
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    smart00570
    Location:985 → 1035
    AWS; associated with SET domains
    smart00317
    Location:1036 → 1159
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cd00084
    Location:433 → 480
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cd15651
    Location:689 → 735
    PHD2_NSD2; PHD finger 2 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15654
    Location:736 → 789
    PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
    cl22851
    Location:1214 → 1256
    PHD_SF; PHD finger superfamily
    cl26267
    Location:543 → 683
    ING; Inhibitor of growth proteins N-terminal histone-binding

  3. XM_021100915.1 → XP_020956574.1  histone-lysine N-methyltransferase NSD2 isoform X4

    UniProtKB/TrEMBL
    A0A480PGH7
    Conserved Domains (7) summary
    cd05837
    Location:198 → 317
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd00084
    Location:433 → 480
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cd15651
    Location:689 → 735
    PHD2_NSD2; PHD finger 2 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15654
    Location:736 → 789
    PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15657
    Location:806 → 846
    PHD4_NSD2; PHD finger 4 found in nuclear SET domain-containing protein 2 (NSD2)
    cl22851
    Location:642 → 684
    PHD_SF; PHD finger superfamily
    cl26267
    Location:543 → 683
    ING; Inhibitor of growth proteins N-terminal histone-binding

  4. XM_021100917.1 → XP_020956576.1  histone-lysine N-methyltransferase NSD2 isoform X6

    UniProtKB/TrEMBL
    A0A287A8W1, A0A4X1T0U1, A0A8D1FGS1, A0A8D1JWI8
    Related
    ENSSSCP00000040233.1, ENSSSCT00000066342.3
    Conserved Domains (2) summary
    cd05837
    Location:198 → 317
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd00084
    Location:433 → 480
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  5. XM_021100916.1 → XP_020956575.1  histone-lysine N-methyltransferase NSD2 isoform X5

    UniProtKB/TrEMBL
    A0A480JJG1, A0A4X1T1A0, A0A8D1FGS1, A0A8D1JWI8
    Conserved Domains (2) summary
    cd05837
    Location:198 → 317
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd00084
    Location:433 → 480
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  6. XM_021100911.1 → XP_020956570.1  histone-lysine N-methyltransferase NSD2 isoform X1

    Conserved Domains (10) summary
    cd05837
    Location:198 → 317
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:915 → 1009
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    smart00570
    Location:1049 → 1099
    AWS; associated with SET domains
    smart00317
    Location:1100 → 1223
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cd00084
    Location:433 → 480
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cd15651
    Location:689 → 735
    PHD2_NSD2; PHD finger 2 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15654
    Location:736 → 789
    PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
    cl22851
    Location:1278 → 1320
    PHD_SF; PHD finger superfamily
    cl26267
    Location:543 → 683
    ING; Inhibitor of growth proteins N-terminal histone-binding
    cl26518
    Location:1282 → 1375
    EPL1; Enhancer of polycomb-like

  7. XM_021100914.1 → XP_020956573.1  histone-lysine N-methyltransferase NSD2 isoform X3

    Conserved Domains (8) summary
    cd05838
    Location:601 → 695
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    smart00570
    Location:735 → 785
    AWS; associated with SET domains
    smart00317
    Location:786 → 909
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cd00084
    Location:119 → 166
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cd15654
    Location:422 → 475
    PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
    cl22851
    Location:964 → 1006
    PHD_SF; PHD finger superfamily
    cl26267
    Location:229 → 369
    ING; Inhibitor of growth proteins N-terminal histone-binding
    cl26518
    Location:968 → 1061
    EPL1; Enhancer of polycomb-like

RNA

  1. XR_002346526.1 RNA Sequence

    Related
    ENSSSCT00000009499.5
Nucleotide Protein
Heading Accession and Version

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