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MCF2L MCF.2 cell line derived transforming sequence like [ Callithrix jacchus (white-tufted-ear marmoset) ]

Gene ID: 100410021, updated on 3-Apr-2024

Summary

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Gene symbol
MCF2L
Gene description
MCF.2 cell line derived transforming sequence like
See related
Ensembl:ENSCJAG00000006690
Gene type
protein coding
RefSeq status
MODEL
Organism
Callithrix jacchus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
41
Annotation release Status Assembly Chr Location
RS_2023_03 current mCalJa1.2.pat.X (GCF_011100555.1) 1 NC_071442.1 (27678062..27895516)
105 previous assembly Callithrix_jacchus_cj1700_1.1 (GCF_009663435.1) 1 NC_048383.1 (27621680..27841287)

Chromosome 1 - NC_071442.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC118152391 Neighboring gene ATPase phospholipid transporting 11A Neighboring gene uncharacterized LOC128930935 Neighboring gene uncharacterized LOC118152664 Neighboring gene uncharacterized LOC103795678 Neighboring gene uncharacterized LOC108590940 Neighboring gene coagulation factor VII Neighboring gene coagulation factor X

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. De novo assembly of the common marmoset transcriptome from NextGen mRNA sequences. Maudhoo MD, et al. Gigascience, 2014. PMID 25243066, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extrinsic component of membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
guanine nucleotide exchange factor DBS

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_011100555.1-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mCalJa1.2.pat.X

Genomic

  1. NC_071442.1 Reference mCalJa1.2.pat.X

    Range
    27678062..27895516
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_035294615.2 → XP_035150506.1  guanine nucleotide exchange factor DBS isoform X2

    UniProtKB/TrEMBL
    A0A8I4A6G4
    Conserved Domains (5) summary
    cd11857
    Location:1114 → 1167
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:76 → 221
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:631 → 808
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:352 → 539
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:815 → 946
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  2. XM_035294629.2 → XP_035150520.1  guanine nucleotide exchange factor DBS isoform X7

    UniProtKB/TrEMBL
    A0A8I4A6G4
    Conserved Domains (5) summary
    cd11857
    Location:1083 → 1136
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:76 → 221
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:631 → 808
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:352 → 539
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:815 → 946
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  3. XM_035294631.2 → XP_035150522.1  guanine nucleotide exchange factor DBS isoform X9

    UniProtKB/TrEMBL
    A0A8I4A6G4
    Conserved Domains (5) summary
    cd11857
    Location:1058 → 1111
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:76 → 221
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:631 → 808
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:352 → 539
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:815 → 946
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  4. XM_054251826.1 → XP_054107801.1  guanine nucleotide exchange factor DBS isoform X5

  5. XM_035294607.2 → XP_035150498.1  guanine nucleotide exchange factor DBS isoform X1

    UniProtKB/TrEMBL
    A0A8I3W8G5
    Conserved Domains (5) summary
    cd11857
    Location:1141 → 1194
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:103 → 248
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:658 → 835
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:379 → 590
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:842 → 973
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  6. XM_035294623.2 → XP_035150514.1  guanine nucleotide exchange factor DBS isoform X3

    UniProtKB/TrEMBL
    A0A8I3W995
    Conserved Domains (5) summary
    cd11857
    Location:1110 → 1163
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:103 → 248
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:658 → 835
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:379 → 590
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:842 → 973
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  7. XM_035294641.1 → XP_035150532.1  guanine nucleotide exchange factor DBS isoform X18

    UniProtKB/TrEMBL
    A0A8I4A6G4
    Conserved Domains (5) summary
    smart00516
    Location:103 → 248
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:658 → 835
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:379 → 590
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:842 → 973
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain
    cl17036
    Location:1085 → 1119
    SH3; Src Homology 3 domain superfamily

  8. XM_035294628.2 → XP_035150519.1  guanine nucleotide exchange factor DBS isoform X6

    UniProtKB/TrEMBL
    A0A8I3W8G5, A0A8I3W951
    Conserved Domains (5) summary
    cd11857
    Location:1084 → 1137
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:46 → 191
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:601 → 778
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:322 → 509
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:785 → 916
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  9. XM_035294635.2 → XP_035150526.1  guanine nucleotide exchange factor DBS isoform X12

    UniProtKB/TrEMBL
    A0A8I3W995
    Conserved Domains (5) summary
    cd11857
    Location:1053 → 1106
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:46 → 191
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:601 → 778
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:322 → 509
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:785 → 916
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  10. XM_035294639.2 → XP_035150530.1  guanine nucleotide exchange factor DBS isoform X16

    UniProtKB/TrEMBL
    A0A8I3W8G5, A0A8I3WHW9
    Conserved Domains (5) summary
    cd11857
    Location:1028 → 1081
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:46 → 191
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:601 → 778
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:322 → 509
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:785 → 916
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  11. XM_035294634.2 → XP_035150525.1  guanine nucleotide exchange factor DBS isoform X11

    UniProtKB/TrEMBL
    A0A8I3W8G5
    Conserved Domains (5) summary
    cd11857
    Location:1055 → 1108
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:17 → 162
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:572 → 749
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:293 → 480
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:756 → 887
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  12. XM_035294627.2 → XP_035150518.1  guanine nucleotide exchange factor DBS isoform X4

    UniProtKB/TrEMBL
    A0A8I3W8G5, A0A8I3WTE5
    Conserved Domains (5) summary
    cd11857
    Location:1088 → 1141
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:50 → 195
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:605 → 782
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:326 → 513
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:789 → 920
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  13. XM_035294632.2 → XP_035150523.1  guanine nucleotide exchange factor DBS isoform X10

    UniProtKB/TrEMBL
    A0A8I3W995
    Conserved Domains (5) summary
    cd11857
    Location:1057 → 1110
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:50 → 195
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:605 → 782
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:326 → 513
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:789 → 920
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  14. XM_035294638.2 → XP_035150529.1  guanine nucleotide exchange factor DBS isoform X15

    UniProtKB/TrEMBL
    A0A8I3W8G5
    Conserved Domains (5) summary
    cd11857
    Location:1032 → 1085
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:50 → 195
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:605 → 782
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:326 → 513
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:789 → 920
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  15. XM_035294633.2 → XP_035150524.1  guanine nucleotide exchange factor DBS isoform X11

    UniProtKB/TrEMBL
    A0A8I3W8G5
    Conserved Domains (5) summary
    cd11857
    Location:1055 → 1108
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:17 → 162
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:572 → 749
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:293 → 480
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:756 → 887
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  16. XM_035294630.2 → XP_035150521.1  guanine nucleotide exchange factor DBS isoform X8

    UniProtKB/TrEMBL
    A0A8I3W8G5
    Conserved Domains (5) summary
    cd11857
    Location:1082 → 1135
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:44 → 189
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:599 → 776
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:320 → 507
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:783 → 914
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  17. XM_035294636.2 → XP_035150527.1  guanine nucleotide exchange factor DBS isoform X13

    UniProtKB/TrEMBL
    A0A8I3W995
    Conserved Domains (5) summary
    cd11857
    Location:1051 → 1104
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:44 → 189
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:599 → 776
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:320 → 507
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:783 → 914
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  18. XM_035294640.2 → XP_035150531.1  guanine nucleotide exchange factor DBS isoform X17

    UniProtKB/TrEMBL
    A0A8I3W8G5
    Conserved Domains (5) summary
    cd11857
    Location:1026 → 1079
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:44 → 189
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:599 → 776
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:320 → 507
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:783 → 914
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  19. XM_035294637.2 → XP_035150528.1  guanine nucleotide exchange factor DBS isoform X14

    UniProtKB/TrEMBL
    A0A5F4VTZ6, A0A8I3W8G5
    Conserved Domains (5) summary
    cd11857
    Location:1046 → 1099
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:62 → 153
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:563 → 740
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:284 → 471
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:747 → 878
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  20. XM_035294642.2 → XP_035150533.1  guanine nucleotide exchange factor DBS isoform X19

    UniProtKB/TrEMBL
    A0A8I3W995
    Conserved Domains (5) summary
    cd11857
    Location:1015 → 1068
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:62 → 153
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:563 → 740
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:284 → 471
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:747 → 878
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  21. XM_035294643.2 → XP_035150534.1  guanine nucleotide exchange factor DBS isoform X20

    UniProtKB/TrEMBL
    A0A8I3W8G5
    Conserved Domains (5) summary
    cd11857
    Location:990 → 1043
    SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
    smart00516
    Location:62 → 153
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    cd00160
    Location:563 → 740
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd00176
    Location:284 → 471
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd01227
    Location:747 → 878
    PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

  22. XM_054251900.1 → XP_054107875.1  guanine nucleotide exchange factor DBS isoform X21

Nucleotide Protein
Heading Accession and Version

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