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nck1b NCK adaptor protein 1b [ Danio rerio (zebrafish) ]

Gene ID: 100334953, updated on 11-Apr-2024

Summary

Official Symbol
nck1bprovided by ZNC
Official Full Name
NCK adaptor protein 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-090317-1
See related
Ensembl:ENSDARG00000075369 AllianceGenome:ZFIN:ZDB-GENE-090317-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable ephrin receptor binding activity; receptor tyrosine kinase binding activity; and signaling adaptor activity. Predicted to be involved in several processes, including cell migration; regulation of response to endoplasmic reticulum stress; and regulation of translation. Predicted to act upstream of or within regulation of translation. Predicted to be located in cytosol and endoplasmic reticulum. Orthologous to human NCK1 (NCK adaptor protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See nck1b in Genome Data Viewer
Location:
chromosome: 24
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (3347514..3407493, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (3315727..3375740, complement)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene succinyl-CoA:glutarate-CoA transferase Neighboring gene glycogenin 1b Neighboring gene 3-hydroxybutyrate dehydrogenase, type 1 Neighboring gene solute carrier family 35 member G2b Neighboring gene isopentenyl-diphosphate delta isomerase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ephrin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables signaling adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cytoplasmic protein NCK1
Names
nck1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    3347514..3407493 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_002666595.6XP_002666641.1  cytoplasmic protein NCK1 isoform X1

    See identical proteins and their annotated locations for XP_002666641.1

    UniProtKB/TrEMBL
    A0A8M1RRX6, E7F6M0
    Related
    ENSDARP00000121375.1, ENSDART00000132648.3
    Conserved Domains (4) summary
    cd11900
    Location:361
    SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
    cd11901
    Location:109163
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:194250
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein
    cl15255
    Location:282378
    SH2; Src homology 2 (SH2) domain
  2. XM_005162524.3XP_005162581.1  cytoplasmic protein NCK1 isoform X2

    UniProtKB/TrEMBL
    A0A8M2B9E1
    Conserved Domains (3) summary
    cd11901
    Location:4599
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:130186
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein
    cl15255
    Location:218314
    SH2; Src homology 2 (SH2) domain