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usp18 ubiquitin specific peptidase 18 [ Danio rerio (zebrafish) ]

Gene ID: 100334535, updated on 11-Apr-2024

Summary

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Official Symbol
usp18provided by ZNC
Official Full Name
ubiquitin specific peptidase 18provided by ZNC
Primary source
ZFIN:ZDB-GENE-100210-2
See related
Ensembl:ENSDARG00000088078 AllianceGenome:ZFIN:ZDB-GENE-100210-2
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch73-352p4.3
Summary
Enables ubiquitin-like protein binding activity. Acts upstream of or within cranial skeletal system development. Orthologous to several human genes including USP18 (ubiquitin specific peptidase 18). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 4
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (5842274..5847941)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (5833698..5839371)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene RAD9-HUS1-RAD1 interacting nuclear orphan 1 Neighboring gene peroxisomal biogenesis factor 26 Neighboring gene LYR motif containing 5a Neighboring gene solute carrier family 5 member 8 Neighboring gene UTP20 small subunit processome component

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Expression characterization, genomic structure and function analysis of fish ubiquitin-specific protease 18 (USP18) genes. Chen C, et al. Dev Comp Immunol, 2015 Oct. PMID 25981749
  2. Structural basis of the specificity of USP18 toward ISG15. Basters A, et al. Nat Struct Mol Biol, 2017 Mar. PMID 28165509, Free PMC Article
  3. Reverse genetic screen reveals that Il34 facilitates yolk sac macrophage distribution and seeding of the brain. Kuil LE, et al. Dis Model Mech, 2019 Mar 8. PMID 30765415, Free PMC Article
  4. Importance of deubiquitinases in zebrafish craniofacial development. Tse WKF. Biochem Biophys Res Commun, 2017 Jun 10. PMID 28450118
  5. Understanding complex dynamics of behavioral, neurochemical and transcriptomic changes induced by prolonged chronic unpredictable stress in zebrafish. Demin KA, et al. Sci Rep, 2020 Nov 17. PMID 33203921, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. USP18's ISG15 specificity is mediated by a small interaction interface.
    Title: Structural basis of the specificity of USP18 toward ISG15.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-like protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cranial skeletal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
ubl carboxyl-terminal hydrolase 18

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    5842274..5847941
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005164532.4 → XP_005164589.1  ubl carboxyl-terminal hydrolase 18

    UniProtKB/TrEMBL
    A0A8M2BBS7, E7EYZ1
    Related
    ENSDARP00000104564.1, ENSDART00000124085.3
    Conserved Domains (2) summary
    cd02257
    Location:97 → 329
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:28 → 328
    UCH; Ubiquitin carboxyl-terminal hydrolase
Nucleotide Protein Strain
Heading Accession and Version

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