gucy2g guanylate cyclase 2g [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gucy2gprovided by ZNC
Official Full Name: guanylate cyclase 2gprovided by ZNC
Primary source: ZFIN:ZDB-GENE-130531-70
See related: Ensembl:ENSDARG00000076776 AllianceGenome:ZFIN:ZDB-GENE-130531-70
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:ch73-92e20.2
Summary: Predicted to enable guanylate cyclase activity and peptide receptor activity. Predicted to be involved in cGMP biosynthetic process and receptor guanylyl cyclase signaling pathway. Predicted to act upstream of or within cyclic nucleotide biosynthetic process; intracellular signal transduction; and protein phosphorylation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 12

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (31460656..31476518)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (31345768..31361480)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables adenylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanylate cyclase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphorus-oxygen lyase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cGMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cGMP biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cyclic nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in receptor guanylyl cyclase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: guanylate cyclase 2G-like

Names: zmp:0000000809

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007123.7 Reference GRCz11 Primary Assembly

Range

31460656..31476518

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009306792.3 → XP_009305067.2 guanylate cyclase 2G-like isoform X1

UniProtKB/TrEMBL

A0A8M3B4S0, E7FDF3

Related

ENSDARP00000033462.6, ENSDART00000031154.7
XM_002663981.6 → XP_002664027.2 guanylate cyclase 2G-like isoform X2

UniProtKB/TrEMBL

A0A8M1RKJ8

Conserved Domains (7) summary

smart00044
Location:845 → 1036

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:871 → 1057

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam01094
Location:54 → 405

ANF_receptor; Receptor family ligand binding region

pfam07701
Location:820 → 865

HNOBA; Heme NO binding associated

pfam07714
Location:546 → 805

Pkinase_Tyr; Protein tyrosine kinase

cl10011
Location:37 → 425

Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

cl21453
Location:530 → 806

PKc_like; Protein Kinases, catalytic domain
XM_009306793.3 → XP_009305068.1 guanylate cyclase 2G-like isoform X3

UniProtKB/TrEMBL

A0A8M3AYJ9

Conserved Domains (7) summary

smart00044
Location:748 → 939

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:774 → 960

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam01094
Location:21 → 308

ANF_receptor; Receptor family ligand binding region

pfam07701
Location:723 → 768

HNOBA; Heme NO binding associated

pfam07714
Location:449 → 708

Pkinase_Tyr; Protein tyrosine kinase

cl10011
Location:16 → 328

Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

cl21453
Location:433 → 709

PKc_like; Protein Kinases, catalytic domain