F8 coagulation factor VIII [Oryctolagus cuniculus (rabbit)] - Gene

Summary

Gene symbol: F8
Gene description: coagulation factor VIII
See related: Ensembl:ENSOCUG00000000142
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Oryctolagus cuniculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: Un

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2023_02	current	UM_NZW_1.0 (GCF_009806435.1)	Unplaced Scaffold	NW_026259224.1 (710491..859889)

NW_026259224.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:: NW_026259224 Unplaced Scaffold Reference UM_NZW_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

ha2714 (e-PCR)
- UniSTS:515587

GDB:177561 (e-PCR)
- UniSTS:154929

GDB:177706 (e-PCR)
- UniSTS:154951

Otor (e-PCR), detects polymorphism
- UniSTS:209587

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables copper ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: coagulation factor VIII

Names: coagulation factor VIII, procoagulant component

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001171271.1 → NP_001164742.1 coagulation factor VIII

See identical proteins and their annotated locations for NP_001164742.1

Status: PROVISIONAL

Source sequence(s)

DP001061

UniProtKB/TrEMBL

A0A5F9CB72, B7NZR5

Related

ENSOCUP00000049694.1, ENSOCUT00000052468.1

Conserved Domains (6) summary

smart00231
Location:2025 → 2173

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00057
Location:2180 → 2329

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cd04227
Location:395 → 571

CuRO_3_FVIII_like; The third cupredoxin domain of coagulation factor VIII and similar proteins

cd11018
Location:1877 → 2020

CuRO_6_FVIII_like; The sixth cupredoxin domain of coagulation factor VIII and similar proteins

cd14452
Location:22 → 202

CuRO_1_FVIII_like; The first cupredoxin domain of coagulation factor VIII and similar proteins

cl19115
Location:1705 → 1865

Cupredoxin; Cupredoxin superfamily