CDH5 cadherin 5, type 2 (vascular endothelium) [Homo sapiens] - Gene

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Summary

Official Symbol: CDH5provided by HGNC
Official Full Name: cadherin 5, type 2 (vascular endothelium)provided by HGNC
Primary source: HGNC:1764
See related: Ensembl:ENSG00000179776; HPRD:03075; MIM:601120; Vega:OTTHUMG00000137495
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: 7B4; CD144; FLJ17376
Summary: This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 16q22.1

Sequence :: Chromosome: 16; NC_000016.9 (66400525..66438689)

See CDH5 in Epigenomics, MapViewer

Chromosome 16 - NC_000016.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Monocyte trans-endothelial migration alters endothelial junctional organization to a more monocyte-permeable state (increased PECAM-1 and decreased VE-cadherin), resulting in the augmented transmigratory activity at a later stage.
Title: Monocyte trans-endothelial migration augments subsequent transmigratory activity with increased PECAM-1 and decreased VE-cadherin at endothelial junctions.
FadA binds vascular endothelial cadherin and alters endothelial integrity.
Title: Fusobacterium nucleatum adhesin FadA binds vascular endothelial cadherin and alters endothelial integrity.
Subtype-selective induction of m-calpain in aorta during atherosclerotic progression is associated with proteolytic disorganization of VE-cadherin and proatherogenic hyperpermeability in cells.
Title: m-Calpain induction in vascular endothelial cells on human and mouse atheromas and its roles in VE-cadherin disorganization and atherosclerosis.
the detection of a soluble VE-cadherin in the patient's serum during a ereditary angioedema attack might have potential clinical interest as a biomarker for the diagnosis
Title: Hereditary angioedema: key role for kallikrein and bradykinin in vascular endothelial-cadherin cleavage and edema formation.
Oocyte donors receiving GnRH agonist or hCG did not show altered serum/follicular fluid VE-cadherin levels.
Title: Effect of GnRH agonist and hCG treatment on VEGF, angiopoietin-2, and VE-cadherin: trying to explain the link to ovarian hyperstimulation syndrome.
specific inhibition of the TGFbeta type I receptor blocked both RA-induced VE-cadherin expression and cell fusion
Title: Retinoic acid mediates regulation of network formation by COUP-TFII and VE-cadherin expression by TGFbeta receptor kinase in breast cancer cells.
tyrosine phosphorylation of VE-cadherin is involved in the increased paracellular permeability of central nervous system-derived vascular endothelium induced by TGF-beta1
Title: Tyrosine phosphorylation of VE-cadherin and claudin-5 is associated with TGF-β1-induced permeability of centrally derived vascular endothelium.
after VE-cadherin induction by DMP1, DMP1 inhibited VEGFR-2 phosphorylation and Src-mediated signaling; DMP1 is identified as a new specific inhibitor of VEGF-induced angiogenesis
Title: Dentin matrix protein 1 induces membrane expression of VE-cadherin on endothelial cells and inhibits VEGF-induced angiogenesis by blocking VEGFR-2 phosphorylation.
Mesenchymal stem cells increased VE-cadherin levels and enhanced recruitment of both VE-cadherin and beta-catenin to the plasma membrane.
Title: Human mesenchymal stem cells inhibit vascular permeability by modulating vascular endothelial cadherin/β-catenin signaling.
Studies indicate that a majority of adult BM HSCs derived from a VE-cadherin ancestor.
Title: Definitive human and mouse hematopoiesis originates from the embryonic endothelium: a new class of HSCs based on VE-cadherin expression.

Submit: New GeneRIF Correction See all (87)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_001786.1	NP_004374.1	CSK	BIND	PubMed	CDH5 (VE-cadherin) interacts with CSK.
NP_001786.1		FGB	BIND	PubMed	B-beta(15-42) interacts with CDH5 (VE-cadherin).
NP_001786.1	NP_003619.2	PKP4	BIND	PubMed	p0071 interacts with VE-cadherin.
P33151	P41240	CSK	HPRD	PubMed
P33151	P35221	CTNNA1	HPRD	PubMed
P33151	P35222	CTNNB1	HPRD	PubMed
P33151	O60716	CTNND1	HPRD	PubMed
P33151	P15924	DSP	HPRD	PubMed
P33151	P29317	EPHA2	HPRD	PubMed
P33151	O00254	F2RL2	HPRD	PubMed
P33151	P02671	FGA	HPRD	PubMed
P33151	P14923	JUP	HPRD	PubMed
P33151	P35968	KDR	HPRD	PubMed
P33151	Q99571	P2RX4	HPRD	PubMed
P33151	O15547	P2RX6	HPRD	PubMed
P33151	Q9NPB6	PARD6A	HPRD	PubMed
P33151	Q99569	PKP4	HPRD	PubMed
P33151	Q06124	PTPN11	HPRD	PubMed
P33151	P23467	PTPRB	HPRD	PubMed
P33151	P29353	SHC1	HPRD	PubMed
P33151	PI3 kinase related kinase SMG1	SMG1	HPRD	PubMed
P33151	P12931	SRC	HPRD	PubMed
P33151	P08670	VIM	HPRD	PubMed
BioGRID:107438	BioGRID:107876	CTNNA1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107438	BioGRID:107880	CTNNB1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107438	BioGRID:107881	CTNND1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107438	BioGRID:108166	DSP	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107438	BioGRID:108534	FGA	BioGRID	PubMed	Reconstituted Complex
BioGRID:107438	BioGRID:109931	JUP	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107438	BioGRID:109992	KDR	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107438	BioGRID:111064	P2RX4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107438	BioGRID:114074	PKP4	BioGRID	PubMed	Two-hybrid
BioGRID:107438	BioGRID:111745	PTPN11	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107438	BioGRID:111751	PTPRB	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:107438	BioGRID:112361	SHC1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107438	BioGRID:113272	VIM	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
RPTP-like protein binding	IEA Inferred from Electronic Annotation more info
beta-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
calcium ion binding	IEA Inferred from Electronic Annotation more info
ion channel binding	IPI Inferred from Physical Interaction more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info
protein phosphatase binding	IEA Inferred from Electronic Annotation more info
receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
adherens junction organization	TAS Traceable Author Statement more info
blood vessel maturation	IEA Inferred from Electronic Annotation more info
cell adhesion	IEA Inferred from Electronic Annotation more info
cell junction assembly	TAS Traceable Author Statement more info
cell-cell junction organization	TAS Traceable Author Statement more info
homophilic cell adhesion	IEA Inferred from Electronic Annotation more info
negative regulation of cell proliferation	IEA Inferred from Electronic Annotation more info
regulation of establishment of cell polarity	IMP Inferred from Mutant Phenotype more info

Component	Evidence Code	Pubs
cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
integral to membrane	IEA Inferred from Electronic Annotation more info
membrane fraction	TAS Traceable Author Statement more info	PubMed
plasma membrane	TAS Traceable Author Statement more info
tight junction	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: cadherin-5

Names: cadherin-5; 7B4 antigen; VE-cadherin; cd144 antigen; endothelial-specific cadherin; vascular endothelial cadherin; cadherin 5, type 2, VE-cadherin (vascular epithelium)

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001795.3 → NP_001786.2 cadherin-5 preproprotein

Status: REVIEWED

Source sequence(s)

AC132186, DC381809, U84722, X59796, X79981

Consensus CDS

CCDS10804.1

UniProtKB/Swiss-Prot

P33151

Related

ENSP00000344115, OTTHUMP00000174777, ENST00000341529, OTTHUMT00000268767

Conserved Domains (2) summary

pfam01049
Location:626 – 777
Blast Score: 358

Cadherin_C; Cadherin cytoplasmic region

cd11304
Location:156 – 254
Blast Score: 247

Cadherin_repeat; Cadherin tandem repeat domain.

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000016.9 Reference GRCh37.p5 Primary Assembly

Range

66400525..66438689

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000148.1 Alternate HuRef

Range

52277104..52314656

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001114117.1: Suppressed sequence

Description

NM_001114117.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC132186.3 (39037..77163)	None
genomic	CH471092.1	EAW83009.1
mRNA	AB035304.1	BAA87418.1
mRNA	AB209908.1	BAD93145.1
mRNA	AK300299.1	BAG62052.1
mRNA	AK300322.1	BAG62074.1
mRNA	AK300461.1	BAG62180.1
mRNA	BC096363.3	AAH96363.1
mRNA	BC096364.3	AAH96364.3
mRNA	BC096365.1	AAH96365.1
mRNA	BC117520.2	AAI17521.1
mRNA	DC381809.1	None
mRNA	U84722.1	AAB41796.1
mRNA	X59796.1	CAA42468.1
mRNA	X79981.1	CAA56306.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P33151.5	GenPept	UniProtKB/Swiss-Prot:P33151
Q4VAI4	GenPept	UniProtKB/TrEMBL:Q4VAI4
Q4VAI5	GenPept	UniProtKB/TrEMBL:Q4VAI5
Q4VAI6	GenPept	UniProtKB/TrEMBL:Q4VAI6
Q59EA3	GenPept	UniProtKB/TrEMBL:Q59EA3