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NPPA natriuretic peptide A [ Ovis aries (sheep) ]

Gene ID: 100294648, updated on 8-Mar-2024

Summary

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Gene symbol
NPPA
Gene description
natriuretic peptide A
See related
EnsemblRapid:ENSOARG00020011755
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Also known as
ANF; ANP; CDD
Orthologs
human mouse all
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Genomic context

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See NPPA in Genome Data Viewer
Location:
chromosome: 12
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 12 NC_056065.1 (41095744..41096823)

Chromosome 12 - NC_056065.1Genomic Context describing neighboring genes Neighboring gene U5 spliceosomal RNA Neighboring gene natriuretic peptide B Neighboring gene chloride voltage-gated channel 6 Neighboring gene methylenetetrahydrofolate reductase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056065.1 Chromosome 12 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ontogeny of atrial natriuretic peptide and its receptor in the lung: effects on perinatal surfactant release. D'Angelis CA, et al. Pediatr Res, 2008 Mar. PMID 18287960
  2. Regional sampling and the effects of experimental heart failure in sheep: differential responses in A, B and C-type natriuretic peptides. Charles CJ, et al. Peptides, 2006 Jan. PMID 16095755
  3. The characterization of ovine genes for atrial, brain, and C-type natriuretic peptides. Aitken GD, et al. Domest Anim Endocrinol, 1999 Feb. PMID 10219521

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ANP and BNP plasma concentrations are sourced from a single organ (the heart) and are subject to substantial extraction across most tissue beds in experimental heart failure.
    Title: Regional sampling and the effects of experimental heart failure in sheep: differential responses in A, B and C-type natriuretic peptides.
  2. increased activity of the atrial natriuretic peptide (ANP)/natriuretic peptide receptor-A (NPR-A) pathway in late gestation may prime the surfactant system, preparing the lung for air breathing.
    Title: Ontogeny of atrial natriuretic peptide and its receptor in the lung: effects on perinatal surfactant release.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables hormone receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cGMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cGMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of systemic arterial blood pressure IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in receptor guanylyl cyclase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
natriuretic peptides A
Names
Prepronatriodilatin
atrial natriuretic factor prohormone
atrial natriuretic peptide prohormone
atriopeptigen
cardiodilatin
natriuretic peptide precursor A
preproANF
preproANP
preproCDD-ANF
proANF
proANP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160027.1 → NP_001153499.1  natriuretic peptides A precursor

    See identical proteins and their annotated locations for NP_001153499.1

    Status: PROVISIONAL

    Source sequence(s)
    AF037465
    UniProtKB/Swiss-Prot
    O46540
    Related
    ENSOARP00020014824.2, ENSOART00020017950.2
    Conserved Domains (1) summary
    smart00183
    Location:122 → 145
    NAT_PEP; Natriuretic peptide

RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

  1. NC_056065.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Range
    41095744..41096823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O46540.1 GenPept UniProtKB/Swiss-Prot:O46540

Gene LinkOut

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