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bcl2.S B-cell CLL/lymphoma 2 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 100271914, updated on 11-Apr-2024

Summary

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Official Symbol
bcl2.S
Official Full Name
B-cell CLL/lymphoma 2 S homeolog
Primary source
Xenbase:XB-GENE-6251434
Locus tag
XELAEV_18033451mg
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
bcl2; bcl-2; xbcl2; xBcl-2
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Genomic context

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Location:
chromosome: 6S
Exon count:
3
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 6S NC_054382.1 (72021018..72110161, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 6S NC_030735.1 (66815561..66907873)

Chromosome 6S - NC_054382.1Genomic Context describing neighboring genes Neighboring gene MARVEL domain-containing protein 3-like Neighboring gene cytochrome c oxidase subunit 4 isoform 1, mitochondrial Neighboring gene vacuolar protein sorting 4 homolog B S homeolog Neighboring gene pyrimidine-specific ribonucleoside hydrolase rihA S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. p27(BBP)/eIF6 acts as an anti-apoptotic factor upstream of Bcl-2 during Xenopus laevis development. De Marco N, et al. Cell Death Differ, 2010 Feb. PMID 19779496
  2. Anti-apoptotic activity and proteasome-mediated degradation of Xenopus Mcl-1 protein in egg extracts. Tsuchiya Y, et al. J Biol Chem, 2011 May 6. PMID 21454490, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
B-cell CLL/lymphoma 2 S homeolog
Names
apoptosis regulator Bcl-2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146093.1 → NP_001139565.1  B-cell CLL/lymphoma 2 S homeolog

    See identical proteins and their annotated locations for NP_001139565.1

    Status: PROVISIONAL

    Source sequence(s)
    AB427203
    UniProtKB/TrEMBL
    A0A974CKE3, B9ZYL7
    Conserved Domains (3) summary
    cd06845
    Location:144 → 255
    Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
    TIGR00865
    Location:1 → 287
    bcl-2; apoptosis regulator
    pfam02180
    Location:9 → 32
    BH4; Bcl-2 homology region 4

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054382.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    72021018..72110161 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018268542.2 → XP_018124031.1  B-cell CLL/lymphoma 2 S homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J0VIJ5, A0A974CKE3
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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