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RGS12 regulator of G protein signaling 12 [ Taeniopygia guttata (zebra finch) ]

Gene ID: 100226709, updated on 8-Mar-2024

Summary

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Gene symbol
RGS12
Gene description
regulator of G protein signaling 12
See related
Ensembl:ENSTGUG00000010365
Gene type
protein coding
RefSeq status
MODEL
Organism
Taeniopygia guttata
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae; Estrildinae; Taeniopygia
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 4
Exon count:
20
Annotation release Status Assembly Chr Location
106 current bTaeGut1.4.pri (GCF_003957565.2) 4 NC_044215.2 (9377108..9461794)
105 previous assembly bTaeGut2.pat.W.v2 (GCF_008822105.2) 4 NC_045002.1 (9311250..9394754)

Chromosome 4 - NC_044215.2Genomic Context describing neighboring genes Neighboring gene huntingtin Neighboring gene Myb/SANT DNA binding domain containing 1 Neighboring gene HGF activator Neighboring gene docking protein 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
regulator of G-protein signaling 12

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Taeniopygia guttata Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bTaeGut1.4.pri Primary Assembly

Genomic

  1. NC_044215.2 Reference bTaeGut1.4.pri Primary Assembly

    Range
    9377108..9461794
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030270633.3 → XP_030126493.3  regulator of G-protein signaling 12 isoform X1

    Conserved Domains (6) summary
    cd08742
    Location:709 → 823
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    smart00390
    Location:1180 → 1201
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    cd00992
    Location:20 → 96
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13162
    Location:226 → 357
    PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
    cd17136
    Location:957 → 1026
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    cd17138
    Location:1027 → 1099
    RBD2_RGS12; Ras-binding domain (RBD) 2 of regulator of G protein signaling 12 (RGS12)

  2. XM_030270636.3 → XP_030126496.3  regulator of G-protein signaling 12 isoform X3

    Conserved Domains (5) summary
    cd08742
    Location:709 → 823
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    cd00992
    Location:20 → 96
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13162
    Location:226 → 357
    PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
    cd17136
    Location:957 → 1026
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    cd17138
    Location:1027 → 1099
    RBD2_RGS12; Ras-binding domain (RBD) 2 of regulator of G protein signaling 12 (RGS12)

  3. XM_030270635.3 → XP_030126495.3  regulator of G-protein signaling 12 isoform X2

    Conserved Domains (5) summary
    cd08742
    Location:709 → 823
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    cd00992
    Location:20 → 96
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13162
    Location:226 → 357
    PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
    cd17136
    Location:957 → 1026
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    cd17138
    Location:1027 → 1099
    RBD2_RGS12; Ras-binding domain (RBD) 2 of regulator of G protein signaling 12 (RGS12)

  4. XM_030270639.3 → XP_030126499.3  regulator of G-protein signaling 12 isoform X6

    UniProtKB/TrEMBL
    H0ZJF0
    Conserved Domains (6) summary
    cd08742
    Location:709 → 823
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    smart00390
    Location:1180 → 1201
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    cd00992
    Location:20 → 96
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13162
    Location:226 → 357
    PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
    cd17136
    Location:957 → 1026
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    cd17138
    Location:1027 → 1099
    RBD2_RGS12; Ras-binding domain (RBD) 2 of regulator of G protein signaling 12 (RGS12)

  5. XM_030270638.3 → XP_030126498.1  regulator of G-protein signaling 12 isoform X5

    UniProtKB/TrEMBL
    A0A674HR07
    Related
    ENSTGUP00000036997.1
    Conserved Domains (7) summary
    cd08742
    Location:61 → 175
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    cd17136
    Location:309 → 378
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    cd17138
    Location:379 → 451
    RBD2_RGS12; Ras-binding domain (RBD) 2 of regulator of G protein signaling 12 (RGS12)
    pfam02188
    Location:533 → 553
    GoLoco; GoLoco motif
    pfam16611
    Location:453 → 524
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:582 → 728
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:181 → 294
    RGS12_us1; Unstructured region of RGS12

  6. XM_030270637.3 → XP_030126497.1  regulator of G-protein signaling 12 isoform X4

    UniProtKB/TrEMBL
    A0A674GT02, A0A674HR07
    Related
    ENSTGUP00000025770.1
    Conserved Domains (7) summary
    cd08742
    Location:69 → 183
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    cd17136
    Location:317 → 386
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    cd17138
    Location:387 → 459
    RBD2_RGS12; Ras-binding domain (RBD) 2 of regulator of G protein signaling 12 (RGS12)
    pfam02188
    Location:541 → 561
    GoLoco; GoLoco motif
    pfam16611
    Location:461 → 532
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:590 → 736
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:189 → 302
    RGS12_us1; Unstructured region of RGS12
Nucleotide Protein
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