BCL2L11 BCL2-like 11 (apoptosis facilitator) [Homo sapiens] - Gene

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Summary

Official Symbol: BCL2L11provided by HGNC
Official Full Name: BCL2-like 11 (apoptosis facilitator)provided by HGNC
Primary source: HGNC:994
See related: Ensembl:ENSG00000153094; HPRD:04828; MIM:603827; Vega:OTTHUMG00000131256
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BAM; BIM; BOD; BimL; BimEL; BIM-beta6; BIM-beta7; BIM-alpha6
Summary: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 2q13

Sequence :: Chromosome: 2; NC_000002.11 (111878491..111926022)

See BCL2L11 in Epigenomics, MapViewer

Chromosome 2 - NC_000002.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Depletion of Mcl-1 sensitized tumor cells to MEK inhibitor-induced cell death, an effect that was antagonized by knockdown of Bim.
Title: Up-regulation of pro-apoptotic protein Bim and down-regulation of anti-apoptotic protein Mcl-1 cooperatively mediate enhanced tumor cell death induced by the combination of ERK kinase (MEK) inhibitor and microtubule inhibitor.
BIM phosphorylation appears to play a key role in apoptosis regulation in chronic lymphocytic leukemia cells, potentially coordinating antigen and microenvironment-derived survival signals.
Title: Mechanisms and clinical significance of BIM phosphorylation in chronic lymphocytic leukemia.
miR-25 directly regulates apoptosis by targeting Bim in ovarian cancer.
Title: MiR-25 regulates apoptosis by targeting Bim in human ovarian cancer.
These results suggest that 18beta-glycyrrhetinic acid induces apoptosis in human breast carcinoma MCF-7 cells via caspase activation and modulation of Akt/FOXO3a/Bim pathway.
Title: 18β-glycyrrhetinic acid induces apoptosis through modulation of Akt/FOXO3a/Bim pathway in human breast cancer MCF-7 cells.
the absence of BIM up-regulation is one of the important mechanisms of glucocorticoids resistance in acute lymphoblast leukemia
Title: Pro-apoptotic protein BIM in apoptosis of glucocorticoid-sensitive and -resistant acute lymphoblastic leukemia CEM cells.
CDK1-dependent phosphorylation of BIM(EL) drives its polyubiquitylation and proteasome-dependent degradation to protect cells during mitotic arrest
Title: CDK1, not ERK1/2 or ERK5, is required for mitotic phosphorylation of BIMEL.
breast cancer cells overexpressing HER2 undergo apoptosis upon depletion of Mcl-1, and this Mcl-1 dependence is due to their constitutive expression of the pro-apoptotic protein Bim
Title: c-Myc dependent expression of pro-apoptotic Bim renders HER2-overexpressing breast cancer cells dependent on anti-apoptotic Mcl-1.
Findings suggest that local IFN production may interact with a genetic factor (PTPN2) to induce aberrant proapoptotic activity of the BH3-only protein Bim, resulting in increased beta-cell apoptosis via JNK activation and the intrinsic apoptotic pathway.
Title: PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic β-cell apoptosis via regulation of the BH3-only protein Bim.
Anti-CD44 mAb A3D8 can inhibit proliferation and induce apoptosis of HL-60 cells by enhancing expression of Bim.
Title: [Early apoptosis of HL-60 cells induced by anti-CD44 McAb A3D8 inhibiting ERK1/2-upregulated Bim expression].
A pathway through c-Raf to Bim that contributes to tipifarnib cytotoxicity in human lymphoid cells but also identify potential determinants of sensitivity to this agent.
Title: Cytotoxicity of farnesyltransferase inhibitors in lymphoid cells mediated by MAPK pathway inhibition and Bim up-regulation.

Submit: New GeneRIF Correction See all (173)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia.

Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.

Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci.

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat (amino acids 36-39) binds tubulin alpha/beta dimers and polymerized microtubules leading to the alteration of microtubule dynamics and activation of a mitochondria-dependent apoptotic pathway that is facilitated by the Bcl-2 relative Bim	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
NC_000002.9	NP_963853.1	FOXO3	BIND	PubMed	FoxO3a interacts with the BCL2L11 (Bim) promoter.
NP_006529.1	NP_000624.1	BCL2	BIND	PubMed	Bim interacts with Bcl-2.
NP_006529.1	NP_612815.1	BCL2L1	BIND	PubMed	Bim interacts with Bcl-XL.
NP_006529.1	NP_004041.1	BCL2L2	BIND	PubMed	Bim interacts with Bcl-w.
O43521	P31749	AKT1	HPRD	PubMed
O43521	P10415	BCL2	HPRD	PubMed
O43521	Q16548	BCL2A1	HPRD	PubMed
O43521	Q07817	BCL2L1	HPRD	PubMed
O43521	O43521	BCL2L11	HPRD	PubMed
O43521	Q92843	BCL2L2	HPRD	PubMed
O43521	P63167	DYNLL1	HPRD	PubMed
O43521	P53779	MAPK10	HPRD	PubMed
O43521	P45983	MAPK8	HPRD	PubMed
O43521	P45984	MAPK9	HPRD	PubMed
O43521	Q07820	MCL1	HPRD	PubMed
O43521	Ring finger and KH domain containing 1	MEX3D	HPRD	PubMed
O43521	P21796	VDAC1	HPRD	PubMed
O43521	P31946	YWHAB	HPRD	PubMed
BioGRID:115335	BioGRID:198056	Akt1	BioGRID	PubMed	Biochemical Activity
BioGRID:115335	BioGRID:107068	BCL2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:115335	BioGRID:107069	BCL2A1	BioGRID	PubMed	Two-hybrid
	NP_612815.1	BCL2L1	BIND	PubMed	Bcl-XL interacts with Bim. This interaction was modelled on a demonstrated interaction between Bcl-XL from an unspecified species and human Bim.
BioGRID:115335	BioGRID:107070	BCL2L1	BioGRID	PubMed	Affinity Capture-Western; FRET; Two-hybrid
BioGRID:115335	BioGRID:107071	BCL2L2	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:115335	BioGRID:107160	BTK	BioGRID	PubMed	Reconstituted Complex
BioGRID:115335	BioGRID:114206	DYNLL1	BioGRID	PubMed	Reconstituted Complex
BioGRID:115335	BioGRID:126680	DYNLL2	BioGRID	PubMed	Reconstituted Complex
BioGRID:115335	BioGRID:109224	GTF2I	BioGRID	PubMed	Reconstituted Complex
BioGRID:115335	BioGRID:110338	MCL1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:115335	BioGRID:112482	SMARCB1	BioGRID	PubMed	Reconstituted Complex
BioGRID:115335	BioGRID:116910	TRIM2	BioGRID	PubMed	Reconstituted Complex
BioGRID:115335	BioGRID:263094	Trim2	BioGRID	PubMed	Affinity Capture-MS; Reconstituted Complex
BioGRID:115335	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115335	BioGRID:113259	VDAC1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115335	BioGRID:249746	Vdac1	BioGRID	PubMed	Reconstituted Complex

Function	Evidence Code	Pubs
contributes_to microtubule binding	IDA Inferred from Direct Assay more info
microtubule binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
B cell apoptosis	IEA Inferred from Electronic Annotation more info
B cell homeostasis	IEA Inferred from Electronic Annotation more info
T cell homeostasis	IEA Inferred from Electronic Annotation more info
activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA Inferred from Direct Assay more info
activation of pro-apoptotic gene products	TAS Traceable Author Statement more info
apoptotic process	TAS Traceable Author Statement more info
cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
cellular process regulating host cell cycle in response to virus	IEA Inferred from Electronic Annotation more info
ear development	IEA Inferred from Electronic Annotation more info
in utero embryonic development	IEA Inferred from Electronic Annotation more info
induction of apoptosis	TAS Traceable Author Statement more info	PubMed
induction of apoptosis by extracellular signals	TAS Traceable Author Statement more info
induction of apoptosis by intracellular signals	TAS Traceable Author Statement more info
kidney development	IEA Inferred from Electronic Annotation more info
male gonad development	IEA Inferred from Electronic Annotation more info
mammary gland development	IEA Inferred from Electronic Annotation more info
myeloid cell homeostasis	IEA Inferred from Electronic Annotation more info
nerve growth factor receptor signaling pathway	TAS Traceable Author Statement more info
odontogenesis of dentin-containing tooth	IEA Inferred from Electronic Annotation more info
positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cell cycle	IEA Inferred from Electronic Annotation more info
positive regulation of intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info
positive regulation of neuron apoptosis	IEA Inferred from Electronic Annotation more info
positive regulation of protein homooligomerization	IDA Inferred from Direct Assay more info
positive regulation of release of cytochrome c from mitochondria	IGI Inferred from Genetic Interaction more info
positive regulation of release of cytochrome c from mitochondria	IMP Inferred from Mutant Phenotype more info	PubMed
post-embryonic development	IEA Inferred from Electronic Annotation more info
post-embryonic organ morphogenesis	IEA Inferred from Electronic Annotation more info
regulation of developmental pigmentation	IEA Inferred from Electronic Annotation more info
regulation of organ growth	IEA Inferred from Electronic Annotation more info
spermatogenesis	IEA Inferred from Electronic Annotation more info
spleen development	IEA Inferred from Electronic Annotation more info
thymus development	IEA Inferred from Electronic Annotation more info
tube formation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
BIM-BCL-2 complex	IDA Inferred from Direct Assay more info
BIM-BCL-xl complex	IDA Inferred from Direct Assay more info
cytoplasm	IEA Inferred from Electronic Annotation more info
cytosol	IDA Inferred from Direct Assay more info
cytosol	TAS Traceable Author Statement more info
endomembrane system	IEA Inferred from Electronic Annotation more info
colocalizes_with microtubule	IDA Inferred from Direct Assay more info
mitochondrial outer membrane	TAS Traceable Author Statement more info
mitochondrion	IEA Inferred from Electronic Annotation more info
peripheral to membrane of membrane fraction	IEA Inferred from Electronic Annotation more info
plasma membrane	TAS Traceable Author Statement more info

General protein information

Preferred Names: bcl-2-like protein 11

Names: bcl-2-like protein 11; bcl2-L-11; bcl-2 interacting protein Bim; bcl-2-related ovarian death agonist; bcl-2 interacting mediator of cell death

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029006.1 RefSeqGene

Range

5001..52532

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001204106.1 → NP_001191035.1 bcl-2-like protein 11 isoform 11

Status: REVIEWED

Description

Transcript Variant: This variant (11) uses an alternate in-frame splice site at the 3' end of an exon compared to variant 1. The resulting isoform (11) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AC096670, AI268146, AK290377, AY305714

UniProtKB/Swiss-Prot

O43521

Conserved Domains (2) summary

pfam06773
Location:4 – 40
Blast Score: 103

Bim_N; Bim protein N-terminus

pfam08945
Location:42 – 77
Blast Score: 149

Bclx_interact; Bcl-x interacting
NM_001204107.1 → NP_001191036.1 bcl-2-like protein 11 isoform 12

Status: REVIEWED

Description

Transcript Variant: This variant (12) uses an alternate in-frame splice site at the 3' end of an exon and contains two more alternate exons compared to variant 1, that causes a frameshift. The resulting isoform (12) lacks an internal segment and has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC096670, AI268146, AK290377, AY423442

Consensus CDS

CCDS56132.1

UniProtKB/Swiss-Prot

O43521

Related

ENSP00000411137, OTTHUMP00000204249, ENST00000439718, OTTHUMT00000314291

Conserved Domains (2) summary

pfam06773
Location:4 – 40
Blast Score: 80

Bim_N; Bim protein N-terminus

pfam08945
Location:42 – 70
Blast Score: 122

Bclx_interact; Bcl-x interacting
NM_001204108.1 → NP_001191037.1 bcl-2-like protein 11 isoform 13

Status: REVIEWED

Description

Transcript Variant: This variant (13) contains an alternate exon compared to variant 1, that causes a frameshift. The resulting isoform (13) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC096670, AI268146, AK290377, AY423443

Consensus CDS

CCDS56135.1

UniProtKB/Swiss-Prot

O43521

Related

ENSP00000350398, ENST00000357757

Conserved Domains (2) summary

pfam06773
Location:4 – 40
Blast Score: 87

Bim_N; Bim protein N-terminus

pfam08945
Location:131 – 166
Blast Score: 174

Bclx_interact; Bcl-x interacting
NM_001204109.1 → NP_001191038.1 bcl-2-like protein 11 isoform 14

Status: REVIEWED

Description

Transcript Variant: This variant (14) lacks an alternate coding exon and contains another alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (14) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC096670, AI268146, AK290377, AY428962

Consensus CDS

CCDS56136.1

UniProtKB/Swiss-Prot

O43521

Related

ENSP00000403727, OTTHUMP00000204251, ENST00000436733, OTTHUMT00000314293

Conserved Domains (1) summary

pfam06773
Location:4 – 40
Blast Score: 84

Bim_N; Bim protein N-terminus
NM_001204110.1 → NP_001191039.1 bcl-2-like protein 11 isoform 15

Status: REVIEWED

Description

Transcript Variant: This variant (15) uses an alternate in-frame splice site at the 3' end of an exon, lacks an alternate coding exon, and contains another alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (15) lacks an alternate segment and has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC096670, AI268146, AK290377, DQ849200

Consensus CDS

CCDS56133.1

UniProtKB/Swiss-Prot

O43521

Related

ENSP00000391292, OTTHUMP00000204253, ENST00000452231, OTTHUMT00000314295

Conserved Domains (2) summary

pfam06773
Location:4 – 40
Blast Score: 85

Bim_N; Bim protein N-terminus

pfam08945
Location:42 – 76
Blast Score: 144

Bclx_interact; Bcl-x interacting
NM_001204111.1 → NP_001191040.1 bcl-2-like protein 11 isoform 16

Status: REVIEWED

Description

Transcript Variant: This variant (16) lacks an alternate in-frame segment and lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (16) lacks an internal segment and has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC096670, AI268146, AK290377, DQ849201

UniProtKB/Swiss-Prot

O43521

Conserved Domains (1) summary

pfam06773
Location:4 – 40
Blast Score: 71

Bim_N; Bim protein N-terminus
NM_001204112.1 → NP_001191041.1 bcl-2-like protein 11 isoform 17

Status: REVIEWED

Description

Transcript Variant: This variant (17) lacks an alternate in-frame segment, lacks an alternate coding exon, and contains an alternate exon compared to variant 1, that causes a frameshift. The resulting isoform (17) lacks an internal segment and has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC096670, AI268146, AK290377, DQ849202

Consensus CDS

CCDS56131.1

UniProtKB/Swiss-Prot

O43521

Related

ENSP00000393781, OTTHUMP00000204250, ENST00000415458, OTTHUMT00000314292

Conserved Domains (1) summary

pfam06773
Location:4 – 40
Blast Score: 77

Bim_N; Bim protein N-terminus
NM_001204113.1 → NP_001191042.1 bcl-2-like protein 11 isoform 18

Status: REVIEWED

Description

Transcript Variant: This variant (18) lacks an alternate in-frame segment and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (18) lacks an internal segment and has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC096670, AK290377, AW629314

UniProtKB/Swiss-Prot

O43521

Related

ENSP00000389225, OTTHUMP00000195502, ENST00000438054, OTTHUMT00000314290

Conserved Domains (1) summary

pfam06773
Location:4 – 40
Blast Score: 81

Bim_N; Bim protein N-terminus
NM_006538.4 → NP_006529.1 bcl-2-like protein 11 isoform 6

Status: REVIEWED

Description

Transcript Variant: This variant (6) is also known as BimL. It lacks a segment within the coding region when compared to variant 1. The translation remains in-frame, and results in an isoform (6) that lacks an internal segment, as compared to isoform 1.

Source sequence(s)

AC096670, AF032458, AI268146, AK290377, BC033694

Consensus CDS

CCDS42731.1

UniProtKB/Swiss-Prot

O43521

Related

ENSP00000309226, OTTHUMP00000204243, ENST00000308659, OTTHUMT00000331936

Conserved Domains (2) summary

pfam06773
Location:4 – 40
Blast Score: 97

Bim_N; Bim protein N-terminus

pfam08945
Location:71 – 107
Blast Score: 164

Bclx_interact; Bcl-x interacting
NM_138621.4 → NP_619527.1 bcl-2-like protein 11 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) is also known as BimEL. It encodes the longest isoform (1).

Source sequence(s)

AC096670, AI268146, BC033694

Consensus CDS

CCDS2089.1

UniProtKB/Swiss-Prot

O43521

Related

ENSP00000376943, OTTHUMP00000161927, ENST00000393256, OTTHUMT00000254022

Conserved Domains (2) summary

pfam06773
Location:4 – 40
Blast Score: 96

Bim_N; Bim protein N-terminus

pfam08945
Location:131 – 167
Blast Score: 177

Bclx_interact; Bcl-x interacting
NM_138622.3 → NP_619528.1 bcl-2-like protein 11 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) is also known as Bim-alpha 1. It contains an extra segment within the coding region, which leads to a translation frameshift, when compared to variant 1. The resulting isoform (2) contains a shorter and distinct C-terminus, as compared to isoform 1.

Source sequence(s)

AB071195, AC096670, AI268146, AK290377

UniProtKB/Swiss-Prot

O43521

Conserved Domains (2) summary

pfam06773
Location:4 – 40
Blast Score: 90

Bim_N; Bim protein N-terminus

pfam08945
Location:131 – 166
Blast Score: 174

Bclx_interact; Bcl-x interacting
NM_138623.3 → NP_619529.1 bcl-2-like protein 11 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) has also been named as Bim-ACD or Bim-alpha 2. It lacks one 5' segment and contains an extra 3' segment within the coding region, when compared to variant 1. The extra segment leads to a translation frameshift. The resulting isoform (3) lacks an internal segment and contains a shorter and distinct C-terminus, as compared to isoform 1.

Source sequence(s)

AB071196, AC096670, AI268146, AK290377

UniProtKB/Swiss-Prot

O43521

Related

ENSP00000401662, OTTHUMP00000204247, ENST00000433098, OTTHUMT00000254023

Conserved Domains (2) summary

pfam06773
Location:4 – 40
Blast Score: 88

Bim_N; Bim protein N-terminus

pfam08945
Location:71 – 106
Blast Score: 159

Bclx_interact; Bcl-x interacting
NM_138624.3 → NP_619530.1 bcl-2-like protein 11 isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) is also known as Bim-beta 1. It contains an extra segment within the coding region, which leads to a translation frameshift, when compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus, as compared to isoform 1.

Source sequence(s)

AB071197, AC096670, AI268146, AK290377

Consensus CDS

CCDS56134.1

UniProtKB/Swiss-Prot

O43521

Related

ENSP00000394640, OTTHUMP00000204248, ENST00000431217, OTTHUMT00000314289

Conserved Domains (1) summary

pfam06773
Location:4 – 40
Blast Score: 81

Bim_N; Bim protein N-terminus
NM_138625.3 → NP_619531.1 bcl-2-like protein 11 isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (5) is also known as Bim-beta 3. It lacks a 5' segment and contains an extra segment within the coding region, when compared to variant 1. The extra segment leads to a translation frameshift, and results in an isoform (5) with an identical N-terminus yet different C-terminus, as compared to isoform 1.

Source sequence(s)

AB071199, AC096670, AI268146, AK290377

UniProtKB/Swiss-Prot

O43521

Related

ENSP00000354879, OTTHUMP00000204246, ENST00000361493, OTTHUMT00000331939

Conserved Domains (1) summary

pfam06773
Location:4 – 40
Blast Score: 78

Bim_N; Bim protein N-terminus
NM_138626.3 → NP_619532.1 bcl-2-like protein 11 isoform 7

Status: REVIEWED

Description

Transcript Variant: This variant (7) has also been named as Bim-ABC or Bim-beta 2. It lacks a segment within the coding region, which leads to a translation frameshift, when compared to variant 1. The resulting isoform (7) contains a shorter and distinct C-terminus, as compared to isoform 1.

Source sequence(s)

AB071198, AC096670, AI268146, AK290377

UniProtKB/Swiss-Prot

O43521

Conserved Domains (1) summary

pfam06773
Location:4 – 40
Blast Score: 81

Bim_N; Bim protein N-terminus
NM_138627.3 → NP_619533.1 bcl-2-like protein 11 isoform 8

Status: REVIEWED

Description

Transcript Variant: This variant (8) has also been named as Bim-A or Bim-beta 4. It lacks two adjacent segments within the coding region, which leads to a translation frameshift, when compared to variant 1. The resulting isoform (8) has an identical N-terminus yet has a shorter and distinct C-terminus, as compared to isoform 1.

Source sequence(s)

AB071200, AC096670, AI268146, AK290377

UniProtKB/Swiss-Prot

O43521

Conserved Domains (1) summary

pfam06773
Location:4 – 40
Blast Score: 67

Bim_N; Bim protein N-terminus
NM_207002.3 → NP_996885.1 bcl-2-like protein 11 isoform 9

Status: REVIEWED

Description

Transcript Variant: This variant (9) uses a different segment for its 3' coding region and 3' UTR when compared to variant 1. The resulting isoform (9) contains a distinct and shorter C-terminus compared to isoform 1.

Source sequence(s)

AA890664, AC096670, AK290377, AY352518

Consensus CDS

CCDS2092.1

UniProtKB/Swiss-Prot

O43521

Related

ENSP00000338374, ENST00000337565

Conserved Domains (1) summary

pfam06773
Location:4 – 40
Blast Score: 104

Bim_N; Bim protein N-terminus
NM_207003.2 → NP_996886.1 bcl-2-like protein 11 isoform 10

Status: REVIEWED

Description

Transcript Variant: This variant (10) is also known as Bim-alpha3. It lacks a 5' segment and contains an extra segment within the coding region, when compared to variant 1. The extra segment leads to a translation frameshift, and results in an isoform (10) with an identical N-terminus yet distinct and shorter C-terminus, as compared to isoform 1.

Source sequence(s)

AC096670, AI268146, AK290377, AY305715

UniProtKB/Swiss-Prot

O43521

Conserved Domains (2) summary

pfam06773
Location:4 – 40
Blast Score: 92

Bim_N; Bim protein N-terminus

pfam08945
Location:42 – 76
Blast Score: 143

Bclx_interact; Bcl-x interacting

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000002.11 Reference GRCh37.p5 Primary Assembly

Range

111878491..111926022

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000134.1 Alternate HuRef

Range

104757646..104805166

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC096670.1	AAY14797.1
genomic	CH471237.1	EAW50364.1
		EAW50365.1
		EAW50366.1
		EAW50367.1
		EAW50369.1
		EAW50370.1
		EAW50371.1
		EAW50372.1
		EAW50373.1
		EAW50374.1
genomic	HI179172.1	CBX53894.1
mRNA	AA854054.1	None
mRNA	AA890664.1	None
mRNA	AB071195.1	BAB78589.1
mRNA	AB071196.1	BAB78590.1
mRNA	AB071197.1	BAB78591.1
mRNA	AB071198.1	BAB78592.1
mRNA	AB071199.1	BAB78593.1
mRNA	AB071200.1	BAB78594.1
mRNA	AF032457.1	AAC39593.1
mRNA	AF032458.1	AAC39594.1
mRNA	AF086141.1	None
mRNA	AF455755.1	AAL57868.1
mRNA	AI268146.1	None
mRNA	AK027160.1	None
mRNA	AK290377.1	BAF83066.1
mRNA	AK291269.1	BAF83958.1
mRNA	AW629314.1	None
mRNA	AY305714.1	AAQ82546.1
mRNA	AY305715.1	AAQ82547.1
mRNA	AY305716.1	AAT34900.1
mRNA	AY352518.1	AAQ62569.1
mRNA	AY423441.1	AAQ99148.1
mRNA	AY423442.1	AAQ99149.1
mRNA	AY423443.1	AAQ99150.1
mRNA	AY428962.1	AAR06908.1
mRNA	BC033694.1	AAH33694.1
mRNA	CN411912.1	None
mRNA	DQ849200.1	ABI13589.1
mRNA	DQ849201.1	ABI13590.1
mRNA	DQ849202.1	ABI13591.1
other-genetic	HQ447452.1	ADQ31938.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
O43521.1	GenPept	UniProtKB/Swiss-Prot:O43521
Q6JTU4	GenPept	UniProtKB/TrEMBL:Q6JTU4
Q8WXB2	GenPept	UniProtKB/TrEMBL:Q8WXB2