BCL2L11 BCL2-like 11 (apoptosis facilitator) [Homo sapiens (human)] - Gene

Summary

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Official Symbol: BCL2L11provided by HGNC
Official Full Name: BCL2-like 11 (apoptosis facilitator)provided by HGNC
Primary source: HGNC:994
See related: Ensembl:ENSG00000153094; HPRD:04828; MIM:603827; Vega:OTTHUMG00000131256
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BAM; BIM; BOD
Summary: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013]

Genomic context

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Location :: 2q13

Sequence :: Chromosome: 2; NC_000002.11 (111878491..111926022)

See BCL2L11 in Epigenomics, MapViewer

Chromosome 2 - NC_000002.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

A significant increase in Bim mRNA in Primary Biliary Cirrhosis was observed, with the most pro-apoptotic isoform dominating in livers of PBC patients.
Title: Activation of FoxO3a/Bim axis in patients with Primary Biliary Cirrhosis.
A low Mcl-1 expression and Bim upregulation after antigen encounter are involved in CD127(low) HCV-specific cytotoxic T cell hyporeactivity during chronic infection.
Title: Persistent hepatitis C virus (HCV) infection impairs HCV-specific cytotoxic T cell reactivity through Mcl-1/Bim imbalance due to CD127 down-regulation.
Bcl-B in complex with the BH3 motif of Bim protected cells from Bax-dependent apoptotic pathways.
Title: The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist.
Proteasome inhibition upregulates Bim and induces caspase-3-dependent apoptosis in mast cells expressing the Kit D816V mutation.
Title: Proteasome inhibition upregulates Bim and induces caspase-3-dependent apoptosis in human mast cells expressing the Kit D816V mutation.
Dihydroartemisinin was associated with the increased expression of the pro-apoptotic gene Bim and a decreased expression of the anti-apoptotic gene Bcl-2 in breast cancer cells.
Title: Involvement of the mitochondrial pathway and Bim/Bcl-2 balance in dihydroartemisinin-induced apoptosis in human breast cancer in vitro.
Investigated the function of Bim during DHA-induced apoptosis in human lung adenocarcinoma cell lines.Confocal imaging showed the translocation of Bim to endoplasmic reticulum (ER) rather than mitochondria during DHA-induced apoptosis.
Title: Dihydroarteminsin-induced apoptosis is not dependent on the translocation of Bim to the endoplasmic reticulum in human lung adenocarcinoma cells.
Findings suggest that inhibiton of Bcl-2, Bcl-xL and PI3K, and release of Bim from Bcl-2/Bcl-xL and GSK3alpha/beta culminating in Bax/Bak activation and apoptosis.
Title: Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3- and Bim-dependent mechanism.
Novel but opposing roles for the p53 and TAp73 in the induction of Noxa and Bim and regulation of apoptosis.
Title: N-(phosphonacetyl)-L-aspartate induces TAp73-dependent apoptosis by modulating multiple Bcl-2 proteins: potential for cancer therapy.
findings demonstrate that the high expression of miR-92a in glioma is significantly correlated with low levels of BCL2L11 (Bim) protein and high-grade glioma
Title: miR-92a is a critical regulator of the apoptosis pathway in glioblastoma with inverse expression of BCL2L11.
Bim, a proapoptotic protein, up-regulated via transcription factor E2F1-dependent mechanism, functions as a prosurvival molecule in cancer
Title: Bim, a proapoptotic protein, up-regulated via transcription factor E2F1-dependent mechanism, functions as a prosurvival molecule in cancer.

Submit: New GeneRIF Correction See all (205)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia.

Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.

Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci.

HIV-1 protein interactions

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Protein	Gene	Interaction	Pubs
Tat, p14	tat	HIV-1 Tat upregulates BIM expression in Tat-infected Jurkat T cells	PubMed
	tat	HIV-1 Tat acetylation at position K28 stimulates its activity to induce the translocation of Bim, a pro-apoptotic protein of the Bcl-2 family, from microtubules to mitochondria	PubMed
	tat	HIV-1 Tat (amino acids 36-39) binds tubulin alpha/beta dimers and polymerized microtubules leading to the alteration of microtubule dynamics and activation of a mitochondria-dependent apoptotic pathway that is facilitated by the Bcl-2 relative Bim	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NC_000002.9	NP_963853.1	FOXO3	BIND	PubMed	FoxO3a interacts with the BCL2L11 (Bim) promoter.
NP_006529.1	NP_000624.1	BCL2	BIND	PubMed	Bim interacts with Bcl-2.
NP_006529.1	NP_612815.1	BCL2L1	BIND	PubMed	Bim interacts with Bcl-XL.
NP_006529.1	NP_004041.1	BCL2L2	BIND	PubMed	Bim interacts with Bcl-w.
O43521	P31749	AKT1	HPRD	PubMed
O43521	P10415	BCL2	HPRD	PubMed
O43521	Q16548	BCL2A1	HPRD	PubMed
O43521	Q07817	BCL2L1	HPRD	PubMed
O43521	O43521	BCL2L11	HPRD	PubMed
O43521	Q92843	BCL2L2	HPRD	PubMed
O43521	P63167	DYNLL1	HPRD	PubMed
O43521	P53779	MAPK10	HPRD	PubMed
O43521	P45983	MAPK8	HPRD	PubMed
O43521	P45984	MAPK9	HPRD	PubMed
O43521	Q07820	MCL1	HPRD	PubMed
O43521	Ring finger and KH domain containing 1	MEX3D	HPRD	PubMed
O43521	P21796	VDAC1	HPRD	PubMed
O43521	P31946	YWHAB	HPRD	PubMed
BioGRID:115335	BioGRID:106848	APP	BioGRID	PubMed	Reconstituted Complex
BioGRID:115335	BioGRID:114922	ATP6V1G1	BioGRID	PubMed	Two-hybrid
BioGRID:115335	BioGRID:114646	AURKB	BioGRID	PubMed	Two-hybrid
BioGRID:115335	BioGRID:198056	Akt1	BioGRID	PubMed	Biochemical Activity
BioGRID:115335	BioGRID:107068	BCL2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:115335	BioGRID:107069	BCL2A1	BioGRID	PubMed	Two-hybrid
	NP_612815.1	BCL2L1	BIND	PubMed	Bcl-XL interacts with Bim. This interaction was modelled on a demonstrated interaction between Bcl-XL from an unspecified species and human Bim.
BioGRID:115335	BioGRID:107070	BCL2L1	BioGRID	PubMed	Affinity Capture-Western; FRET; Two-hybrid
BioGRID:115335	BioGRID:107071	BCL2L2	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:115335	BioGRID:107160	BTK	BioGRID	PubMed	Reconstituted Complex
BioGRID:115335	BioGRID:114457	BTRC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115335	BioGRID:115262	CD302	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115335	BioGRID:107574	CISH	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115335	BioGRID:114031	CUL2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115335	BioGRID:110810	DRG1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115335	BioGRID:114206	DYNLL1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:115335	BioGRID:126680	DYNLL2	BioGRID	PubMed	Reconstituted Complex
BioGRID:115335	BioGRID:116887	FBXW11	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115335	BioGRID:121256	FEM1C	BioGRID	PubMed	Two-hybrid
BioGRID:115335	BioGRID:108558	FGL1	BioGRID	PubMed	Two-hybrid
BioGRID:115335	BioGRID:115671	GNB2L1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:115335	BioGRID:109224	GTF2I	BioGRID	PubMed	Reconstituted Complex
BioGRID:115335	BioGRID:109316	HDAC2	BioGRID	PubMed	Negative Genetic
BioGRID:115335	BioGRID:109540	HSPA4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115335	BioGRID:111585	MAPK8	BioGRID	PubMed	Biochemical Activity
BioGRID:115335	BioGRID:110338	MCL1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:115335	BioGRID:114309	RIOK3	BioGRID	PubMed	Two-hybrid
BioGRID:115335	BioGRID:112482	SMARCB1	BioGRID	PubMed	Reconstituted Complex
BioGRID:115335	BioGRID:112785	TCEB2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115335	BioGRID:116910	TRIM2	BioGRID	PubMed	Reconstituted Complex
BioGRID:115335	BioGRID:263094	Trim2	BioGRID	PubMed	Affinity Capture-MS; Reconstituted Complex
BioGRID:115335	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115335	BioGRID:119006	UBQLN2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115335	BioGRID:113259	VDAC1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115335	BioGRID:113269	VHL	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115335	BioGRID:249746	Vdac1	BioGRID	PubMed	Reconstituted Complex

Pathways from BioSystems

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Activation of BH3-only proteins, organism-specific biosystem (from REACTOME)
Activation of BH3-only proteins, organism-specific biosystemThe BH3-only members act as sentinels that selectively trigger apoptosis in response to developmental cues or stress-signals like DNA damages. Widely expressed mammalian BH3-only proteins are thought...
Activation of BIM and translocation to mitochondria, organism-specific biosystem (from REACTOME)
Activation of BIM and translocation to mitochondria, organism-specific biosystemBIM acts as a sentinel to check the integrity of the cytoskeleton. It exists as two variant proteins: BIM-EL and BIM-L. In healthy cells, these two isoforms are sequestered to the dynein motor comple...
Apoptosis, organism-specific biosystem (from WikiPathways)
Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
Apoptosis, organism-specific biosystem (from REACTOME)
Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
Apoptosis Modulation and Signaling, organism-specific biosystem (from WikiPathways)
Apoptosis Modulation and Signaling, organism-specific biosystemApoptosis, or cell death program, can be activated by various mechanisms within the extrinsic and the intrinsic pathway. While activation of cell death receptors leads to the engagement of the extrin...
B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ?? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation o...
BDNF signaling pathway, organism-specific biosystem (from WikiPathways)
BDNF signaling pathway, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is a neurotrophin essential for growth, differentiation, plasticity, and survival of neurons. BDNF is also required for processes such as energy metabolism, b...
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members, organism-specific biosystem (from REACTOME)
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members, organism-specific biosystem
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem (from REACTOME)
Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystemp75NTR is a key regulator of neuronal apoptosis, both during development and after injury. Apoptosis is triggered by binding of either mature neurotrophin or proneurotrophin (proNGF, proBDNF). ProNG...
DNA damage response (only ATM dependent), organism-specific biosystem (from WikiPathways)
DNA damage response (only ATM dependent), organism-specific biosystemThis is the second pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and TP53) which are connected with the first DNA damage response pathway. In...
ErbB signaling pathway, organism-specific biosystem (from WikiPathways)
ErbB signaling pathway, organism-specific biosystemThe ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with ...
FoxO family signaling, organism-specific biosystem (from Pathway Interaction Database)
FoxO family signaling, organism-specific biosystem
FoxO family signaling
IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
IL-7 Signaling Pathway, organism-specific biosystem (from WikiPathways)
IL-7 Signaling Pathway, organism-specific biosystemInterleukin-7 belongs to a family of cytokines, which includes IL-2, IL-4, IL-9, IL-15 and IL-21. It signals through a receptor complex consisting of IL-7 receptor alpha chain (IL7RA) and a common ga...
Intrinsic Pathway for Apoptosis, organism-specific biosystem (from REACTOME)
Intrinsic Pathway for Apoptosis, organism-specific biosystemThe intrinsic (Bcl-2 inhibitable or mitochondrial) pathway of apoptosis functions in response to various types of intracellular stress including growth factor withdrawal, DNA damage, unfolding stress...
NRAGE signals death through JNK, organism-specific biosystem (from REACTOME)
NRAGE signals death through JNK, organism-specific biosystemOnce bound by either NGF or proNGF, p75NTR interacts with NRAGE, thus leading to phosphorylation and activation of JUN Kinase (JNK). JNK controls apoptosis in two ways: it induces transcription of pr...
PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
Signalling by NGF, organism-specific biosystem (from REACTOME)
Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
p75 NTR receptor-mediated signalling, organism-specific biosystem (from REACTOME)
p75 NTR receptor-mediated signalling, organism-specific biosystemBesides signalling through the tyrosine kinase receptors TRK A, B, and C, the mature neurotrophins NGF, BDNF, and NT3/4 signal through their common receptor p75NTR. NGF binding to p75NTR activates a ...
p75(NTR)-mediated signaling, organism-specific biosystem (from Pathway Interaction Database)
p75(NTR)-mediated signaling, organism-specific biosystem
p75(NTR)-mediated signaling

General gene information

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Markers

RH99076 (e-PCR)
- UniSTS:90012

RH91369 (e-PCR)
- UniSTS:85445

D2S1892 (e-PCR), detects polymorphism
- UniSTS:66798

WI-11737 (e-PCR)
- UniSTS:72182

Homology

Homologs of the BCL2L11 gene: The BCL2L11 gene is conserved in Rhesus monkey, dog, mouse, and rat.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
contributes_to microtubule binding	IDA Inferred from Direct Assay more info
microtubule binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein heterodimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
B cell apoptotic process	IEA Inferred from Electronic Annotation more info
B cell homeostasis	IEA Inferred from Electronic Annotation more info
T cell homeostasis	IEA Inferred from Electronic Annotation more info
activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA Inferred from Direct Assay more info
apoptotic process	TAS Traceable Author Statement more info
apoptotic signaling pathway	TAS Traceable Author Statement more info
brain development	IEA Inferred from Electronic Annotation more info
cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
cellular process regulating host cell cycle in response to virus	IEA Inferred from Electronic Annotation more info
developmental pigmentation	IEA Inferred from Electronic Annotation more info
ear development	IEA Inferred from Electronic Annotation more info
in utero embryonic development	IEA Inferred from Electronic Annotation more info
induction of apoptosis	TAS Traceable Author Statement more info	PubMed
intrinsic apoptotic signaling pathway	TAS Traceable Author Statement more info
kidney development	IEA Inferred from Electronic Annotation more info
male gonad development	IEA Inferred from Electronic Annotation more info
mammary gland development	IEA Inferred from Electronic Annotation more info
myeloid cell homeostasis	IEA Inferred from Electronic Annotation more info
neurotrophin TRK receptor signaling pathway	TAS Traceable Author Statement more info
odontogenesis of dentin-containing tooth	IEA Inferred from Electronic Annotation more info
positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cell cycle	IEA Inferred from Electronic Annotation more info
positive regulation of fibroblast apoptotic process	IDA Inferred from Direct Assay more info	PubMed
positive regulation of intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info
positive regulation of intrinsic apoptotic signaling pathway	TAS Traceable Author Statement more info
positive regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
positive regulation of protein homooligomerization	IDA Inferred from Direct Assay more info
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	TAS Traceable Author Statement more info
positive regulation of release of cytochrome c from mitochondria	IGI Inferred from Genetic Interaction more info
positive regulation of release of cytochrome c from mitochondria	IMP Inferred from Mutant Phenotype more info	PubMed
post-embryonic organ morphogenesis	IEA Inferred from Electronic Annotation more info
regulation of developmental pigmentation	IEA Inferred from Electronic Annotation more info
regulation of organ growth	IEA Inferred from Electronic Annotation more info
response to endoplasmic reticulum stress	IDA Inferred from Direct Assay more info
spermatogenesis	IEA Inferred from Electronic Annotation more info
spleen development	IEA Inferred from Electronic Annotation more info
thymus development	IEA Inferred from Electronic Annotation more info
tube formation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
BIM-BCL-2 complex	IDA Inferred from Direct Assay more info
BIM-BCL-xl complex	IDA Inferred from Direct Assay more info
cytosol	IDA Inferred from Direct Assay more info
cytosol	TAS Traceable Author Statement more info
endomembrane system	IEA Inferred from Electronic Annotation more info
extrinsic to membrane	IEA Inferred from Electronic Annotation more info
colocalizes_with microtubule	IDA Inferred from Direct Assay more info
mitochondrial outer membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: bcl-2-like protein 11

Names: bcl-2-like protein 11; bcl-2 interacting protein Bim; bcl-2-related ovarian death agonist; bcl-2 interacting mediator of cell death

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029006.1 RefSeqGene

Range

5001..52532

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001204106.1 → NP_001191035.1 bcl-2-like protein 11 isoform 11

Status: REVIEWED

Description

Transcript Variant: This variant (11, also known as BimS) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (11) is shorter, compared to isoform 1.

Source sequence(s)

AC096670, AI268146, AK290377, AY305714

UniProtKB/Swiss-Prot

O43521

Conserved Domains (2) summary

pfam06773
Location:4 – 40
Blast Score: 103

Bim_N; Bim protein N-terminus

pfam08945
Location:42 – 77
Blast Score: 149

Bclx_interact; Bcl-x interacting
NM_001204107.1 → NP_001191036.1 bcl-2-like protein 11 isoform 12

Status: REVIEWED

Description

Transcript Variant: This variant (12) uses an alternate in-frame splice site in the 5' coding region, contains two alternate internal exons, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (12) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.

Source sequence(s)

AC096670, AI268146, AK290377, AY423442

Consensus CDS

CCDS56132.1

UniProtKB/Swiss-Prot

O43521

Conserved Domains (2) summary

pfam06773
Location:4 – 40
Blast Score: 80

Bim_N; Bim protein N-terminus

pfam08945
Location:42 – 70
Blast Score: 122

Bclx_interact; Bcl-x interacting
NM_001204108.1 → NP_001191037.1 bcl-2-like protein 11 isoform 13

Status: REVIEWED

Description

Transcript Variant: This variant (13) contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (13) has a shorter and distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.

Source sequence(s)

AC096670, AI268146, AK290377, AY423443

Consensus CDS

CCDS56135.1

UniProtKB/Swiss-Prot

O43521

Conserved Domains (2) summary

pfam06773
Location:4 – 40
Blast Score: 87

Bim_N; Bim protein N-terminus

pfam08945
Location:131 – 166
Blast Score: 174

Bclx_interact; Bcl-x interacting
NM_001204109.1 → NP_001191038.1 bcl-2-like protein 11 isoform 14

Status: REVIEWED

Description

Transcript Variant: This variant (14) lacks an internal exon, contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (14) has a shorter and distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.

Source sequence(s)

AC096670, AI268146, AK290377, AY428962

Consensus CDS

CCDS56136.1

UniProtKB/Swiss-Prot

O43521

Conserved Domains (1) summary

pfam06773
Location:4 – 40
Blast Score: 84

Bim_N; Bim protein N-terminus
NM_001204110.1 → NP_001191039.1 bcl-2-like protein 11 isoform 15

Status: REVIEWED

Description

Transcript Variant: This variant (15) uses an alternate in-frame splice site in the 5' coding region, contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (15) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.

Source sequence(s)

AC096670, AI268146, AK290377, DQ849200

Consensus CDS

CCDS56133.1

UniProtKB/Swiss-Prot

O43521

Conserved Domains (2) summary

pfam06773
Location:4 – 40
Blast Score: 85

Bim_N; Bim protein N-terminus

pfam08945
Location:42 – 76
Blast Score: 144

Bclx_interact; Bcl-x interacting
NM_001204111.1 → NP_001191040.1 bcl-2-like protein 11 isoform 16

Status: REVIEWED

Description

Transcript Variant: This variant (16) lacks an in-frame segment in the 5' coding region, and lacks an exon in the 3' coding region which results in a frameshift, compared to variant 1. The resulting isoform (16) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC096670, AI268146, AK290377, DQ849201

UniProtKB/Swiss-Prot

O43521

Conserved Domains (1) summary

pfam06773
Location:4 – 40
Blast Score: 71

Bim_N; Bim protein N-terminus
NM_001204112.1 → NP_001191041.1 bcl-2-like protein 11 isoform 17

Status: REVIEWED

Description

Transcript Variant: This variant (17) lacks an alternate in-frame segment in the 5' coding region, lacks an internal exon, and contains an alternate internal exon, compared to variant 1. The resulting isoform (17) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.

Source sequence(s)

AC096670, AI268146, AK290377, DQ849202

Consensus CDS

CCDS56131.1

UniProtKB/Swiss-Prot

O43521

Conserved Domains (1) summary

pfam06773
Location:4 – 40
Blast Score: 77

Bim_N; Bim protein N-terminus
NM_001204113.1 → NP_001191042.1 bcl-2-like protein 11 isoform 18

Status: REVIEWED

Description

Transcript Variant: This variant (18) lacks an alternate in-frame segment and differs in the 3' UTR and coding sequence, compared to variant 1. The resulting isoform (18) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC096670, AK290377, AW629314

UniProtKB/Swiss-Prot

O43521

Conserved Domains (1) summary

pfam06773
Location:4 – 40
Blast Score: 81

Bim_N; Bim protein N-terminus
NM_006538.4 → NP_006529.1 bcl-2-like protein 11 isoform 6

Status: REVIEWED

Description

Transcript Variant: This variant (6, also known as BimL) lacks an in-frame segment in the 5' coding coding region, compared to variant 1. The resulting isoform (6) is shorter, compared to isoform 1.

Source sequence(s)

AC096670, AF032458, AI268146, AK290377, BC033694

Consensus CDS

CCDS42731.1

UniProtKB/Swiss-Prot

O43521

Conserved Domains (2) summary

pfam06773
Location:4 – 40
Blast Score: 97

Bim_N; Bim protein N-terminus

pfam08945
Location:71 – 107
Blast Score: 164

Bclx_interact; Bcl-x interacting
NM_138621.4 → NP_619527.1 bcl-2-like protein 11 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1, also known as BimEL) encodes the longest isoform (1).

Source sequence(s)

AC096670, AI268146, BC033694

Consensus CDS

CCDS2089.1

UniProtKB/Swiss-Prot

O43521

Related

ENSP00000376943, OTTHUMP00000161927, ENST00000393256, OTTHUMT00000254022

Conserved Domains (2) summary

pfam06773
Location:4 – 40
Blast Score: 96

Bim_N; Bim protein N-terminus

pfam08945
Location:131 – 167
Blast Score: 177

Bclx_interact; Bcl-x interacting
NM_138622.3 → NP_619528.1 bcl-2-like protein 11 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2, also known as Bim-alpha1) contains an alternate internal exon and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (2) contains a shorter and distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.

Source sequence(s)

AB071195, AC096670, AI268146, AK290377

UniProtKB/Swiss-Prot

O43521

Conserved Domains (2) summary

pfam06773
Location:4 – 40
Blast Score: 90

Bim_N; Bim protein N-terminus

pfam08945
Location:131 – 166
Blast Score: 174

Bclx_interact; Bcl-x interacting
NM_138623.3 → NP_619529.1 bcl-2-like protein 11 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3, also known as Bim-ACD and Bim-alpha2) lacks a 5' segment, contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.

Source sequence(s)

AB071196, AC096670, AI268146, AK290377

UniProtKB/Swiss-Prot

O43521

Conserved Domains (2) summary

pfam06773
Location:4 – 40
Blast Score: 88

Bim_N; Bim protein N-terminus

pfam08945
Location:71 – 106
Blast Score: 159

Bclx_interact; Bcl-x interacting
NM_138624.3 → NP_619530.1 bcl-2-like protein 11 isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4, also known as Bim-beta1) contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.

Source sequence(s)

AB071197, AC096670, AI268146, AK290377

Consensus CDS

CCDS56134.1

UniProtKB/Swiss-Prot

O43521

Conserved Domains (1) summary

pfam06773
Location:4 – 40
Blast Score: 81

Bim_N; Bim protein N-terminus
NM_138625.3 → NP_619531.1 bcl-2-like protein 11 isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (5, also known as Bim-beta3) uses an alternate splice site in the 5' coding region, contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (5) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.

Source sequence(s)

AB071199, AC096670, AI268146, AK290377

UniProtKB/Swiss-Prot

O43521

Conserved Domains (1) summary

pfam06773
Location:4 – 40
Blast Score: 78

Bim_N; Bim protein N-terminus
NM_138626.3 → NP_619532.1 bcl-2-like protein 11 isoform 7

Status: REVIEWED

Description

Transcript Variant: This variant (7, also known as Bim-ABC and Bim-beta2) lacks an exon in the 3' coding region which results in a frameshift, compared to variant 1. The resulting isoform (7) has a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AB071198, AC096670, AI268146, AK290377

UniProtKB/Swiss-Prot

O43521

Conserved Domains (1) summary

pfam06773
Location:4 – 40
Blast Score: 81

Bim_N; Bim protein N-terminus
NM_138627.3 → NP_619533.1 bcl-2-like protein 11 isoform 8

Status: REVIEWED

Description

Transcript Variant: This variant (8, also known as Bim-A and Bim-beta4) uses an alternate splice site in the 5' coding region, and lacks an exon in the 3' coding region which results in a frameshift, compared to variant 1. The resulting isoform (8) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AB071200, AC096670, AI268146, AK290377

UniProtKB/Swiss-Prot

O43521

Conserved Domains (1) summary

pfam06773
Location:4 – 40
Blast Score: 67

Bim_N; Bim protein N-terminus
NM_207002.3 → NP_996885.1 bcl-2-like protein 11 isoform 9

Status: REVIEWED

Description

Transcript Variant: This variant (9, also known as Bim-gamma) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. The resulting isoform (9) has a distinct and shorter C-terminus, compared to isoform 1.

Source sequence(s)

AA890664, AC096670, AK290377, AY352518

Consensus CDS

CCDS2092.1

UniProtKB/Swiss-Prot

O43521

Related

ENSP00000338374, ENST00000337565

Conserved Domains (1) summary

pfam06773
Location:4 – 40
Blast Score: 104

Bim_N; Bim protein N-terminus
NM_207003.2 → NP_996886.1 bcl-2-like protein 11 isoform 10

Status: REVIEWED

Description

Transcript Variant: This variant (10, also known as Bim-alpha3) uses an alternate splice site in the 5' coding region, contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (10) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.

Source sequence(s)

AC096670, AI268146, AK290377, AY305715

UniProtKB/Swiss-Prot

O43521

Conserved Domains (2) summary

pfam06773
Location:4 – 40
Blast Score: 92

Bim_N; Bim protein N-terminus

pfam08945
Location:42 – 76
Blast Score: 143

Bclx_interact; Bcl-x interacting

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000002.11 Reference GRCh37.p10 Primary Assembly

Range

111878491..111926022

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000134.1 Alternate HuRef

Range

104757646..104805166

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018913.1 Alternate CHM1_1.0

Range

111391851..111439472

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01001561.1 (505768..553288)	None
genomic	AC096670.1	AAY14797.1
genomic	AMYH01010925.1 (495009..495060)	None
genomic	AMYH01010926.1	None
genomic	AMYH01010927.1	None
genomic	CH471237.1	EAW50364.1
		EAW50365.1
		EAW50366.1
		EAW50367.1
		EAW50369.1
		EAW50370.1
		EAW50371.1
		EAW50372.1
		EAW50373.1
		EAW50374.1
genomic	HI179172.1	CBX53894.1
mRNA	AA854054.1	None
mRNA	AA890664.1	None
mRNA	AB071195.1	BAB78589.1
mRNA	AB071196.1	BAB78590.1
mRNA	AB071197.1	BAB78591.1
mRNA	AB071198.1	BAB78592.1
mRNA	AB071199.1	BAB78593.1
mRNA	AB071200.1	BAB78594.1
mRNA	AF032457.1	AAC39593.1
mRNA	AF032458.1	AAC39594.1
mRNA	AF086141.1	None
mRNA	AF455755.1	AAL57868.1
mRNA	AI268146.1	None
mRNA	AK027160.1	None
mRNA	AK290377.1	BAF83066.1
mRNA	AK291269.1	BAF83958.1
mRNA	AW629314.1	None
mRNA	AY305714.1	AAQ82546.1
mRNA	AY305715.1	AAQ82547.1
mRNA	AY305716.1	AAT34900.1
mRNA	AY352518.1	AAQ62569.1
mRNA	AY423441.1	AAQ99148.1
mRNA	AY423442.1	AAQ99149.1
mRNA	AY423443.1	AAQ99150.1
mRNA	AY428962.1	AAR06908.1
mRNA	BC033694.1	AAH33694.1
mRNA	CN411912.1	None
mRNA	DQ849200.1	ABI13589.1
mRNA	DQ849201.1	ABI13590.1
mRNA	DQ849202.1	ABI13591.1
other-genetic	HQ447452.1	ADQ31938.1