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    Atp2a2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 [ Cavia porcellus (domestic guinea pig) ]

    Gene ID: 100174978, updated on 20-Feb-2013
    Gene symbol
    Atp2a2
    Gene description
    ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Cavia porcellus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricognathi; Caviidae; Cavia
    Also known as
    SERCA2
    Location :
    chromosome: Un
    See Atp2a2 in MapViewer

    NT_176304.1Genomic Context describing neighboring genes Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 7 Neighboring gene intraflagellar transport 81 Neighboring gene anaphase-promoting complex subunit 7-like Neighboring gene atlastin-2-like

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Targeted sarcoplasmic reticulum Ca2+ ATPase 2a gene delivery to restore electrical stability in the failing heart. Cutler MJ, et al. Circulation, 2012 Oct 23. PMID 23019291.
    2. Differential expression of P-type ATPases in intestinal epithelial cells: identification of putative new atp1a1 splice-variant. Rocafull MA, et al. Biochem Biophys Res Commun, 2010 Jan 1. PMID 19900414.

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. SERCA2a gene transfer in the failing heart not only improves contractile function but also directly restores electric stability through amelioration of key arrhythmogenic substrate.
      Title: Targeted sarcoplasmic reticulum Ca2+ ATPase 2a gene delivery to restore electrical stability in the failing heart.
    Submit: New GeneRIF Correction

    Markers

    Names
    ATPase, Ca++ transporting, cardiac muscle, slow twitch 2

    RefSeqs of Annotated Genomes: Build 1.1

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Cavpor3.0 Primary Assembly

    Genomic

    1. NT_176304.1

      Range
      1976162..2030121
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003462931.1 → XP_003462979.1  

      UniProtKB/TrEMBL
      H0UZ89
      Conserved Domains (6) summary
      TIGR01116
      Location:53 – 988
      Blast Score: 4317
      ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
      pfam00122
      Location:93 – 341
      Blast Score: 547
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:783 – 986
      Blast Score: 401
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:4 – 72
      Blast Score: 199
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12710
      Location:597 – 711
      Blast Score: 108
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:418 – 527
      Blast Score: 258
      Hydrolase_like2; Putative hydrolase of sodium-potassium ATPase alpha subunit
    Nucleotide Protein
    Heading Accession and Version
    genomic AAKN02052343.1 (612..15510) None
    genomic AAKN02052344.1 None
    mRNA EF489482.1 ACB20765.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

      Supplemental Content

      Table of contents

      Related information

      • BioProjects
        BioProjects related to a gene
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • Taxonomy
        Link to related taxonomy entry
      • UniSTS
        Related UniSTS records

      Links to other resources

      General information

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