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    A2M alpha-2-macroglobulin [ Pongo abelii (Sumatran orangutan) ]

    Gene ID: 100173946, updated on 20-Feb-2013
    Gene symbol
    A2M
    Gene description
    alpha-2-macroglobulin
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pongo abelii
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo
    Location :
    chromosome: 12
    Sequence :
    Chromosome: 12; NC_012603.1 (9124831..9181130, complement)
    See A2M in MapViewer

    Chromosome 12 - NC_012603.1Genomic Context describing neighboring genes Neighboring gene voltage-dependent anion-selective channel protein 2-like Neighboring gene putative uncharacterized protein C12orf33-like Neighboring gene keratin, type I cytoskeletal 19-like Neighboring gene protein BTG1-like

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    • Complement and coagulation cascades, organism-specific biosystem (from KEGG)
      Complement and coagulation cascades, organism-specific biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...
    • Complement and coagulation cascades, conserved biosystem (from KEGG)
      Complement and coagulation cascades, conserved biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...
    Preferred Names
    alpha-2-macroglobulin
    Names
    alpha-2-macroglobulin
    alpha-2-M

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001133457.1NP_001126929.1  alpha-2-macroglobulin precursor

      Status: PROVISIONAL

      Source sequence(s)
      CR861207
      UniProtKB/Swiss-Prot
      Q5R4N8
      Conserved Domains (7) summary
      cd02897
      Location:9581264
      Blast Score: 1154
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:738828
      Blast Score: 347
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:129221
      Blast Score: 255
      A2M_N; MG2 domain
      pfam07677
      Location:13761463
      Blast Score: 330
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:10101266
      Blast Score: 1000
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:459607
      Blast Score: 322
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam11974
      Location:28110
      Blast Score: 138
      MG1; Alpha-2-macroglobulin MG1 domain

    RefSeqs of Annotated Genomes: Build 1.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference P_pygmaeus_2.0.2 Primary Assembly

    Genomic

    1. NC_012603.1 Reference P_pygmaeus_2.0.2 Primary Assembly

      Range
      9124831..9181130, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

      Supplemental Content

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