SMAD2 SMAD family member 2 [Pongo abelii (Sumatran orangutan)] - Gene

Summary

Gene symbol: SMAD2
Gene description: SMAD family member 2
Locus tag: CR201_G0028321
See related: Ensembl:ENSPPYG00000009144
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Pongo abelii
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPonAbe1-v2.0_pri (GCF_028885655.2)	17	NC_072002.2 (62614381..62703880, complement)
RS_2023_04	previous assembly	NHGRI_mPonAbe1-v1.1-hic.freeze_pri (GCF_028885655.1)	18	NC_072003.1 (42879596..42974575, complement)

Chromosome 17 - NC_072002.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH18445 (e-PCR)
- UniSTS:62505

MARC_10275-10276:998924078:1 (e-PCR)
- UniSTS:267092

Smad2 (e-PCR), detects polymorphism
- UniSTS:466570

SHGC-148706 (e-PCR)
- UniSTS:176569

RH47015 (e-PCR)
- UniSTS:52667

SHGC-16176 (e-PCR)
- UniSTS:68808

MADH2_1658 (e-PCR)
- UniSTS:277460

RH17857 (e-PCR)
- UniSTS:72445

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables I-SMAD binding	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in SMAD protein signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in activin receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed
involved_in transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of heteromeric SMAD protein complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: mothers against decapentaplegic homolog 2

Names: MAD homolog 2; SMAD 2; mothers against DPP homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001132904.2 → NP_001126376.1 mothers against decapentaplegic homolog 2

See identical proteins and their annotated locations for NP_001126376.1

Status: PROVISIONAL

Source sequence(s)

CR860198

UniProtKB/Swiss-Prot

Q5R7C0

Conserved Domains (2) summary

cd10491
Location:8 → 172

MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3

cd10985
Location:266 → 456

MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

RefSeqs of Annotated Genomes: GCF_028885655.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

Genomic

NC_072002.2 Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

Range

62614381..62703880 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063716775.1 → XP_063572845.1 mothers against decapentaplegic homolog 2 isoform X3

UniProtKB/TrEMBL

A0A2J8UE99, A0A8I5U5T1
XM_063716773.1 → XP_063572843.1 mothers against decapentaplegic homolog 2 isoform X2
XM_024235718.3 → XP_024091486.1 mothers against decapentaplegic homolog 2 isoform X1

UniProtKB/TrEMBL

A0A2J8UE82, A0A6D2VZ52, H2NWB2

Conserved Domains (2) summary

cd10491
Location:8 → 172

MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3

cd10985
Location:266 → 456

MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
XM_024235720.3 → XP_024091488.1 mothers against decapentaplegic homolog 2 isoform X3

UniProtKB/TrEMBL

A0A2J8UC54, A0A2J8UC58, A0A2J8UE99, A0A8I5U5T1, H2NNK3

Related

ENSPPYP00000025094.1

Conserved Domains (2) summary

cd10491
Location:8 → 142

MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3

cd10985
Location:236 → 426

MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
XM_054537505.2 → XP_054393480.1 mothers against decapentaplegic homolog 2 isoform X2
XM_024235719.3 → XP_024091487.1 mothers against decapentaplegic homolog 2 isoform X1

UniProtKB/TrEMBL

A0A2J8UE82, A0A6D2VZ52, H2NWB2

Conserved Domains (2) summary

cd10491
Location:8 → 172

MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3

cd10985
Location:266 → 456

MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
XM_054537506.2 → XP_054393481.1 mothers against decapentaplegic homolog 2 isoform X4