MDM2 MDM2 proto-oncogene [Pongo abelii (Sumatran orangutan)] - Gene

Summary

Gene symbol: MDM2
Gene description: MDM2 proto-oncogene
Locus tag: CR201_G0013995
See related: Ensembl:ENSPPYG00000004754
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Pongo abelii
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPonAbe1-v2.0_pri (GCF_028885655.2)	10	NC_071995.2 (66812565..66854874)
RS_2023_04	previous assembly	NHGRI_mPonAbe1-v1.1-hic.freeze_pri (GCF_028885655.1)	12	NC_071997.1 (66813454..66850476)

Chromosome 10 - NC_071995.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

GDB:434012 (e-PCR)
- UniSTS:157204

G66928 (e-PCR)
- UniSTS:166955

G66929 (e-PCR)
- UniSTS:166956

RH45825 (e-PCR)
- UniSTS:69681

D8S2278 (e-PCR)
- UniSTS:473906

D8S2279 (e-PCR)
- UniSTS:473907

D11S3732 (e-PCR)
- UniSTS:152962

GDB:371587 (e-PCR)
- UniSTS:156866

PMC100259P1 (e-PCR)
- UniSTS:270055

MDM2_1161 (e-PCR)
- UniSTS:277486

PMC129072P1 (e-PCR)
- UniSTS:270587

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables p53 binding	IEA Inferred from Electronic Annotation more info	PubMed
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell cycle	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of gene expression	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: E3 ubiquitin-protein ligase Mdm2

Names: Mdm2 p53 binding protein homolog; Mdm2, p53 E3 ubiquitin protein ligase homolog

NP_001124685.1

EC 2.3.2.27

XP_024111800.1

EC 2.3.2.27

XP_054382224.1

EC 2.3.2.27

XP_054382225.1

EC 2.3.2.27

XP_054382226.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001131213.1 → NP_001124685.1 E3 ubiquitin-protein ligase Mdm2

See identical proteins and their annotated locations for NP_001124685.1

Status: PROVISIONAL

Source sequence(s)

CR857268

UniProtKB/TrEMBL

A0A2J8W101, A0A8I5YNQ1, Q5RF93

Related

ENSPPYP00000043129.1, ENSPPYT00000051204.1

Conserved Domains (3) summary

pfam00641
Location:305 → 334

zf-RanBP; Zn-finger in Ran binding protein and others

pfam02201
Location:51 → 98

SWIB; SWIB/MDM2 domain

pfam13920
Location:442 → 489

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

RefSeqs of Annotated Genomes: GCF_028885655.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

Genomic

NC_071995.2 Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

Range

66812565..66854874

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054526249.2 → XP_054382224.1 E3 ubiquitin-protein ligase Mdm2 isoform X1

UniProtKB/TrEMBL

A0A2J8W102, A0A8I5U8C6
XM_054526250.2 → XP_054382225.1 E3 ubiquitin-protein ligase Mdm2 isoform X2
XM_024256032.3 → XP_024111800.1 E3 ubiquitin-protein ligase Mdm2 isoform X2

UniProtKB/TrEMBL

A0A2J8W101, A0A8I5YNQ1

Conserved Domains (3) summary

pfam00641
Location:299 → 328

zf-RanBP; Zn-finger in Ran binding protein and others

pfam02201
Location:45 → 96

SWIB; SWIB/MDM2 domain

cd16783
Location:435 → 491

mRING-HC-C2H2C4_MDM2; Modified RING finger, HC subclass (C2H2C4-type), found in E3 ubiquitin-protein ligase MDM2 and similar proteins
XM_054526251.2 → XP_054382226.1 E3 ubiquitin-protein ligase Mdm2 isoform X3