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ikzf2 IKAROS family zinc finger 2 [ Danio rerio (zebrafish) ]

Gene ID: 100150224, updated on 27-Mar-2024

Summary

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Official Symbol
ikzf2provided by ZNC
Official Full Name
IKAROS family zinc finger 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-100922-169
See related
Ensembl:ENSDARG00000069111 AllianceGenome:ZFIN:ZDB-GENE-100922-169
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:zfos-1425h8.1
Summary
Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Orthologous to human IKZF2 (IKAROS family zinc finger 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 9
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (39957723..40016702, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (40147385..40214839, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101883027 Neighboring gene uncharacterized LOC103911682 Neighboring gene erb-b2 receptor tyrosine kinase 4b Neighboring gene uncharacterized LOC108191338 Neighboring gene uncharacterized LOC110440048 Neighboring gene uncharacterized LOC103911684

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Evolution of the Ikaros gene family: implications for the origins of adaptive immunity. John LB, et al. J Immunol, 2009 Apr 15. PMID 19342657
  2. Zebrafish Regulatory T Cells Mediate Organ-Specific Regenerative Programs. Hui SP, et al. Dev Cell, 2017 Dec 18. PMID 29257949
  3. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein Helios
Names
helios

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161762.1 → NP_001155234.1  zinc finger protein Helios

    See identical proteins and their annotated locations for NP_001155234.1

    Status: PROVISIONAL

    Source sequence(s)
    BN001213
    UniProtKB/TrEMBL
    A0A8M1NS00, C4XVB5
    Related
    ENSDARP00000153057.1, ENSDART00000184726.1
    Conserved Domains (4) summary
    COG5048
    Location:112 → 206
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:115 → 135
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:113 → 135
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:127 → 152
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    39957723..40016702 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017357618.2 → XP_017213107.1  zinc finger protein Helios isoform X1

    UniProtKB/TrEMBL
    A0A0R4IIC7, A0A8M6Z2F7
    Related
    ENSDARP00000147611.1, ENSDART00000183005.1

  2. XM_017357619.2 → XP_017213108.1  zinc finger protein Helios isoform X2

    UniProtKB/TrEMBL
    A0A8M1NS00, C4XVB5
    Conserved Domains (4) summary
    COG5048
    Location:112 → 206
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:115 → 135
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:113 → 135
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:127 → 152
    zf-H2C2_2; Zinc-finger double domain

  3. XM_017357617.2 → XP_017213106.1  zinc finger protein Helios isoform X1

    UniProtKB/TrEMBL
    A0A0R4IIC7, A0A8M6Z2F7
    Related
    ENSDARP00000135372.1, ENSDART00000166918.3
Nucleotide Protein Strain
Heading Accession and Version

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