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cacna2d3 calcium channel, voltage dependent, alpha2/delta subunit 3 [ Danio rerio (zebrafish) ]

Gene ID: 100148645, updated on 11-Apr-2024

Summary

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Official Symbol
cacna2d3provided by ZNC
Official Full Name
calcium channel, voltage dependent, alpha2/delta subunit 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-030616-133
See related
Ensembl:ENSDARG00000078760 AllianceGenome:ZFIN:ZDB-GENE-030616-133
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
dory; si:dz136d19.1; si:busm1-136d19.1; csi:busm1-136d19.1
Summary
Predicted to enable voltage-gated calcium channel activity. Predicted to act upstream of or within calcium ion transmembrane transport and regulation of ion transmembrane transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of voltage-gated calcium channel complex. Orthologous to human CACNA2D3 (calcium voltage-gated channel auxiliary subunit alpha2delta 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 11
Exon count:
38
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (36688793..36765921, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (36426812..36503839, complement)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene si:ch211-11c3.9 Neighboring gene pheromone-regulated protein PRM7-like Neighboring gene parapinopsin b Neighboring gene calcium channel, voltage-dependent, L type, alpha 1D subunit, a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. cacna2d3, a voltage-gated calcium channel subunit, functions in vertebrate habituation learning and the startle sensitivity threshold. Santistevan NJ, et al. PLoS One, 2022. PMID 35834485, Free PMC Article
  2. gemini encodes a zebrafish L-type calcium channel that localizes at sensory hair cell ribbon synapses. Sidi S, et al. J Neurosci, 2004 Apr 28. PMID 15115817, Free PMC Article
  3. A genome-wide screen identifies PAPP-AA-mediated IGFR signaling as a novel regulator of habituation learning. Wolman MA, et al. Neuron, 2015 Mar 18. PMID 25754827, Free PMC Article
  4. Candidate risk genes for bipolar disorder are highly conserved during evolution and highly interconnected. Franklin C, et al. Bipolar Disord, 2021 Jun. PMID 32959503
  5. Identification of Dmrt2a downstream genes during zebrafish early development using a timely controlled approach. Pinto RA, et al. BMC Dev Biol, 2018 Jun 19. PMID 29914374, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. cacna2d3, a voltage-gated calcium channel subunit, functions in vertebrate habituation learning and the startle sensitivity threshold.
    Title: cacna2d3, a voltage-gated calcium channel subunit, functions in vertebrate habituation learning and the startle sensitivity threshold.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within habituation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
part_of voltage-gated calcium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
calcium channel, voltage dependent, alpha2/delta subunit 3; voltage-dependent calcium channel subunit alpha-2/delta-3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    36688793..36765921 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005172924.4 → XP_005172981.1  voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X4

    UniProtKB/TrEMBL
    A0A8M2BK51
    Conserved Domains (4) summary
    cd01463
    Location:237 → 420
    vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
    pfam02743
    Location:447 → 534
    Cache_1; Cache domain
    pfam08399
    Location:108 → 224
    VWA_N; VWA N-terminal
    pfam08473
    Location:550 → 623
    VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd

  2. XM_017358363.2 → XP_017213852.1  voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z1U2

  3. XM_005172923.4 → XP_005172980.1  voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X3

    UniProtKB/TrEMBL
    A0A8M2BK91
    Conserved Domains (4) summary
    cd01463
    Location:237 → 420
    vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
    pfam02743
    Location:447 → 535
    Cache_1; Cache domain
    pfam08399
    Location:108 → 224
    VWA_N; VWA N-terminal
    pfam08473
    Location:551 → 624
    VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd

  4. XM_002663814.6 → XP_002663860.2  voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X2

    UniProtKB/TrEMBL
    A0A8M1RM50, F1R3X8
    Related
    ENSDARP00000001281.10, ENSDART00000002055.11
    Conserved Domains (4) summary
    cd01463
    Location:237 → 420
    vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
    pfam02743
    Location:447 → 540
    Cache_1; Cache domain
    pfam08399
    Location:108 → 224
    VWA_N; VWA N-terminal
    pfam08473
    Location:556 → 629
    VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd
Nucleotide Protein
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