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TH tyrosine hydroxylase [ Equus caballus (horse) ]

Gene ID: 100146648, updated on 8-Mar-2024

Summary

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Gene symbol
TH
Gene description
tyrosine hydroxylase
See related
Ensembl:ENSECAG00000024625
Gene type
protein coding
RefSeq status
MODEL
Organism
Equus caballus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 12
Exon count:
13
Annotation release Status Assembly Chr Location
103 current EquCab3.0 (GCF_002863925.1) 12 NC_009155.3 (34469802..34477573, complement)
102 previous assembly EquCab2.0 (GCF_000002305.2) 12 NC_009155.2 (30663966..30671943, complement)

Chromosome 12 - NC_009155.3Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111776001 Neighboring gene insulin like growth factor 2 Neighboring gene insulin Neighboring gene uncharacterized LOC111776002 Neighboring gene achaete-scute family bHLH transcription factor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables tyrosine 3-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in dopamine biosynthetic process from tyrosine IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in heart development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to ethanol IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to hypoxia IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine 3-monooxygenase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Equus caballus Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference EquCab3.0 Primary Assembly

Genomic

  1. NC_009155.3 Reference EquCab3.0 Primary Assembly

    Range
    34469802..34477573 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023654707.1 → XP_023510475.1  tyrosine 3-monooxygenase

    UniProtKB/TrEMBL
    F6QQR7
    Related
    ENSECAP00000022117.4, ENSECAT00000026505.4
    Conserved Domains (3) summary
    pfam00351
    Location:164 → 493
    Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase
    pfam12549
    Location:2 → 26
    TOH_N; Tyrosine hydroxylase N terminal
    cl09141
    Location:38 → 155
    ACT; ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme
Nucleotide Protein
Heading Accession and Version

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