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KLLN killin, p53-regulated DNA replication inhibitor [ Homo sapiens (human) ]

Gene ID: 100144748, updated on 26-Aug-2014
Official Symbol
KLLNprovided by HGNC
Official Full Name
killin, p53-regulated DNA replication inhibitorprovided by HGNC
Primary source
HGNC:37212
See related
Ensembl:ENSG00000227268; MIM:612105; Vega:OTTHUMG00000186455
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CWS4; KILLIN
Summary
The protein encoded by this intronless gene is found in the nucleus, where it can inhibit DNA synthesis and promote S phase arrest coupled to apoptosis. The expression of this DNA binding protein is upregulated by transcription factor p53. [provided by RefSeq, Dec 2012]
See KLLN in Epigenomics, MapViewer
Location:
10q23
Exon count:
1
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 10 NC_000010.11 (87859161..87863437, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (89618918..89623194, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene 3'-phosphoadenosine 5'-phosphosulfate synthase 2 Neighboring gene ATPase family, AAA domain containing 1 Neighboring gene cofilin 1 (non-muscle) pseudogene 1 Neighboring gene phosphatase and tensin homolog Neighboring gene ribosomal protein L11 pseudogene 3 Neighboring gene mediator complex subunit 6 pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033079.1 

    Range
    5001..9277
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001126049.1NP_001119521.1  killin

    See proteins identical to NP_001119521.1

    Status: REVIEWED

    Source sequence(s)
    EU552092
    Consensus CDS
    CCDS44454.1
    UniProtKB/Swiss-Prot
    B2CW77
    Related
    ENSP00000392204, OTTHUMP00000274466, ENST00000445946, OTTHUMT00000473179

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000010.11 

    Range
    87859161..87863437
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000142.1 

    Range
    83253736..83258012
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 

    Range
    89901216..89905492
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)