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KLLN killin, p53-regulated DNA replication inhibitor [ Homo sapiens (human) ]

Gene ID: 100144748, updated on 13-Jun-2016
Official Symbol
KLLNprovided by HGNC
Official Full Name
killin, p53-regulated DNA replication inhibitorprovided by HGNC
Primary source
HGNC:HGNC:37212
See related
Ensembl:ENSG00000227268 MIM:612105; Vega:OTTHUMG00000186455
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CWS4; KILLIN
Summary
The protein encoded by this intronless gene is found in the nucleus, where it can inhibit DNA synthesis and promote S phase arrest coupled to apoptosis. The expression of this DNA binding protein is upregulated by transcription factor p53. [provided by RefSeq, Dec 2012]
Orthologs
Location:
10q23
Exon count:
1
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 10 NC_000010.11 (87859161..87863437, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (89618918..89623194, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene 3'-phosphoadenosine 5'-phosphosulfate synthase 2 Neighboring gene ATPase family, AAA domain containing 1 Neighboring gene cofilin 1 pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 78, pseudogene Neighboring gene uncharacterized LOC107987150 Neighboring gene phosphatase and tensin homolog Neighboring gene ribosomal protein L11 pseudogene 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell cycle arrest IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033079.1 RefSeqGene

    Range
    5001..9277
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001126049.1NP_001119521.1  killin

    See identical proteins and their annotated locations for NP_001119521.1

    Status: REVIEWED

    Source sequence(s)
    EU552092
    Consensus CDS
    CCDS44454.1
    UniProtKB/Swiss-Prot
    B2CW77
    Related
    ENSP00000392204, OTTHUMP00000274466, ENST00000445946, OTTHUMT00000473179

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p7 Primary Assembly

    Range
    87859161..87863437 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p7 PATCHES

Genomic

  1. NW_013171807.1 Reference GRCh38.p7 PATCHES

    Range
    74984..79261 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 Alternate CHM1_1.1

    Range
    89901216..89905492 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)