abca1b ATP-binding cassette, sub-family A (ABC1), member 1B [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: abca1bprovided by ZNC
Official Full Name: ATP-binding cassette, sub-family A (ABC1), member 1Bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9826
See related: Ensembl:ENSDARG00000079009 AllianceGenome:ZFIN:ZDB-GENE-030131-9826
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sb:cb407; im:7136239; wu:fa07e06; zgc:171581
Summary: Predicted to enable ATPase-coupled transmembrane transporter activity; phosphatidylcholine floppase activity; and phosphatidylserine floppase activity. Predicted to be involved in phospholipid efflux. Predicted to act upstream of or within transmembrane transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in several structures, including hypochord; mesoderm; notochord; solid lens vesicle; and yolk syncytial layer. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hypolipoproteinemia (multiple); obesity; and type 2 diabetes mellitus. Orthologous to human ABCA1 (ATP binding cassette subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 14

Exon count:: 47

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (6424015..6519076)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (6117271..6212349)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylcholine floppase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylserine floppase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in phospholipid efflux	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ATP-binding cassette, sub-family A (ABC1), member 1B; phospholipid-transporting ATPase ABCA1b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001114586.2 → NP_001108058.2 phospholipid-transporting ATPase ABCA1b

Status: VALIDATED

Source sequence(s)

CT009487

UniProtKB/TrEMBL

A0A8M1NHI3, F8W2X9

Related

ENSDARP00000124570.2, ENSDART00000148461.3

Conserved Domains (3) summary

TIGR01257
Location:1 → 2231

rim_protein; retinal-specific rim ABC transporter

cd03263
Location:902 → 1121

ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A

pfam13732
Location:2135 → 2227

DUF4162; Domain of unknown function (DUF4162)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007125.7 Reference GRCz11 Primary Assembly

Range

6424015..6519076

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005173080.4 → XP_005173137.1 ATP-binding cassette, sub-family A (ABC1), member 1B isoform X1

UniProtKB/TrEMBL

A0A8M2BKC3, E7F2Y6

Related

ENSDARP00000051555.4, ENSDART00000051556.6

Conserved Domains (3) summary

TIGR01257
Location:1 → 2242

rim_protein; retinal-specific rim ABC transporter

cd03263
Location:902 → 1121

ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A

pfam13732
Location:2146 → 2238

DUF4162; Domain of unknown function (DUF4162)