HDAC6 histone deacetylase 6 [Homo sapiens] - Gene

Help top of page

Summary

Official Symbol: HDAC6provided by HGNC
Official Full Name: histone deacetylase 6provided by HGNC
Primary source: HGNC:14064
Locus tag: JM21
See related: Ensembl:ENSG00000094631; HPRD:02228; MIM:300272; Vega:OTTHUMG00000034496
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HD6; JM21; FLJ16239
Summary: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008]

Help top of page

Genomic context

Location :: Xp11.23

Sequence :: Chromosome: X; NC_000023.10 (48660487..48683380)

See HDAC6 in Epigenomics, MapViewer

Chromosome X - NC_000023.10 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study suggests a novel role for dysferlin in myogenesis and identifies HDAC6 as a novel dysferlin-interacting protein.
Title: Dysferlin interacts with histone deacetylase 6 and increases alpha-tubulin acetylation.
find that a balanced, GRK2/HDAC6-mediated regulation of tubulin acetylation differentially modulates the early and late stages of cellular spreading
Title: A novel GRK2/HDAC6 interaction modulates cell spreading and motility.
accumulation of HDAC6 is specific to alpha-synucleinopathy
Title: Accumulation of histone deacetylase 6, an aggresome-related protein, is specific to Lewy bodies and glial cytoplasmic inclusions.
structural and mechanistic bases for the role of HDAC6 in aggresome formation and further suggest a novel ubiquitin-mediated signaling pathway
Title: Protein aggregates are recruited to aggresome by histone deacetylase 6 via unanchored ubiquitin C termini.
Recent studies in this review have found that HDAC6 has the novel ability to capture alpha-tubulin as a substrate and regulate the physiological level of its acetylated form.
Title: HDAC6 α-tubulin deacetylase: a potential therapeutic target in neurodegenerative diseases.
Data show that knockdown of histone deacetylase 6, a protein known to interact with tau, reveals a requirement for HDAC6 activity in tau aggresome formation.
Title: Proteasome inhibition drives HDAC6-dependent recruitment of tau to aggresomes.
Results suggest that targeting HDAC6 alone or in combination with chemotherapy could provide a novel approach to treat ALL.
Title: Tubacin suppresses proliferation and induces apoptosis of acute lymphoblastic leukemia cells.
HDAC6 regulates the interaction between Ku70 and Bax in neuroblastoma cells and may be a therapeutic target in this pediatric solid tumor.
Title: HDAC6 deacetylates Ku70 and regulates Ku70-Bax binding in neuroblastoma.
In ELT-3 leiomyoma cells, silencing HDAC6 expression substantially reduced ERalpha expression, lowered estrogen response, and inhibited ELT-3 cell growth.
Title: Histone deacetylase 6 regulates estrogen receptor alpha in uterine leiomyoma.
These data suggest that the acetylation status of CTTN modulated by the NACC1-HDAC6 deacetylation system induces acceleration of melanoma cell migration activity via an actin-dependent cellular process
Title: Nucleus accumbens-associated 1 contributes to cortactin deacetylation and augments the migration of melanoma cells.

Submit: New GeneRIF Correction See all (71)

Help top of page

Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Help top of page

HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	The binding of HIV-1 gp120 to CD4+-permissive cells increases the level of acetylated alpha-tubulin in a CD4-dependent manner; overexpression of Histone Deacetylase 6 (HDAC6) inhibits the acetylation of alpha-tubulin and prevents HIV-1-cell fusion	PubMed
Envelope transmembrane glycoprotein gp41	env	Overexpression of Histone Deacetylase 6 (HDAC6) inhibits the acetylation of alpha-tubulin and remarkably prevents HIV-1 gp120/41-dependent cell fusion	PubMed

Go to the HIV-1, Human Protein Interaction Database

Help top of page

Products	Interactant	Other Gene	Source	Pubs	Description
NP_006035.2	NP_005169.1	BCL3	BIND	PubMed	HDAC6 interacts with BCL-3. This interaction was modelled on a demonstrated interaction between HDAC6 from an unspecified species and human BCL-3.
Q9UBN7	P20749	BCL3	HPRD	PubMed
Q9UBN7	Q6W2J9	BCOR	HPRD	PubMed
Q9UBN7	Q9HCU9	BRMS1	HPRD	PubMed
Q9UBN7	Q09472	EP300	HPRD	PubMed
Q9UBN7	Q96DB2	HDAC11	HPRD	PubMed
Q9UBN7	Q9Y263	PLAA	HPRD	PubMed
Q9UBN7	Q01201	RELB	HPRD	PubMed
Q9UBN7	Q13950	RUNX2	HPRD	PubMed
Q9UBN7	Q8IXJ6	SIRT2	HPRD	PubMed
Q9UBN7	P68363	TUBA1B	HPRD	PubMed
Q9UBN7	P68366	TUBA4A	HPRD	PubMed
Q9UBN7	P07437	TUBB	HPRD	PubMed
Q9UBN7	P62988	UBB	HPRD	PubMed
Q9UBN7	Ubiquitin B	UBB	HPRD	PubMed
Q9UBN7	P55072	VCP	HPRD	PubMed
Q9UBN7	Q05516	ZBTB16	HPRD	PubMed
BioGRID:115330	BioGRID:115425	ACTR1A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115330	BioGRID:112666	AURKA	BioGRID	PubMed	Biochemical Activity; Reconstituted Complex
BioGRID:115330	BioGRID:122851	BBS10	BioGRID	PubMed	Two-hybrid
BioGRID:115330	BioGRID:107074	BCL3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115330	BioGRID:120228	BCOR	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115330	BioGRID:107311	CBFA2T3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115330	BioGRID:107460	CDKN1A	BioGRID	PubMed	Reconstituted Complex
BioGRID:115330	BioGRID:107506	CFTR	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115330	BioGRID:112763	CNTN2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115330	BioGRID:107714	CORD1	BioGRID	PubMed	Reconstituted Complex
BioGRID:115330	BioGRID:107842	CSNK2A2	BioGRID	PubMed	Biochemical Activity; Reconstituted Complex
BioGRID:115330	BioGRID:107880	CTNNB1	BioGRID	PubMed	Biochemical Activity
BioGRID:115330	BioGRID:108332	CTTN	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:115330	BioGRID:107920	CYLD	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:115330	BioGRID:123559	DIAPH3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115330	BioGRID:115360	DNAJB6	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115330	BioGRID:127919	DNAJB8	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115330	BioGRID:114206	DYNLL1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115330	BioGRID:113896	DYSF	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115330	BioGRID:113999	EEA1	BioGRID	PubMed	Co-fractionation
BioGRID:115330	BioGRID:108276	EGFR	BioGRID	PubMed	Affinity Capture-Western; Co-fractionation; PCA
BioGRID:115330	BioGRID:108347	EP300	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115330	BioGRID:108376	ERBB2	BioGRID	PubMed	PCA
BioGRID:115330	BioGRID:108377	ERBB3	BioGRID	PubMed	PCA
BioGRID:115330	BioGRID:108378	ERBB4	BioGRID	PubMed	PCA
BioGRID:115330	BioGRID:108489	FAT1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115330	BioGRID:108497	FBP1	BioGRID	PubMed	Two-hybrid
BioGRID:115330	BioGRID:108625	FNTA	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:115330	BioGRID:108627	FNTB	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:115330	BioGRID:115448	G3BP1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:115330	BioGRID:109186	GSK3A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115330	BioGRID:109187	GSK3B	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115330	BioGRID:122970	HDAC11	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115330	BioGRID:109514	HES1	BioGRID	PubMed	Two-hybrid
BioGRID:115330	BioGRID:109338	HIF1A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115330	BioGRID:109552	HSP90AA1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115330	BioGRID:109541	HSPA5	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115330	BioGRID:109547	HSPB1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115330	BioGRID:200263	Hdac6	BioGRID	PubMed	Affinity Capture-MS
BioGRID:115330	BioGRID:124093	LCOR	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:115330	BioGRID:114801	LPXN	BioGRID	PubMed	Two-hybrid
BioGRID:115330	BioGRID:116581	MAPRE1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115330	BioGRID:110308	MAPT	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:115330	BioGRID:121947	MIIP	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:115330	BioGRID:110700	MYD88	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115330	BioGRID:116763	NACAD	BioGRID	PubMed	Two-hybrid
BioGRID:115330	BioGRID:110759	NASP	BioGRID	PubMed	Two-hybrid
BioGRID:115330	BioGRID:114012	NR0B2	BioGRID	PubMed	Reconstituted Complex
BioGRID:115330	BioGRID:109165	NR3C1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:115330	BioGRID:109407	NR4A1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:115330	BioGRID:111571	PKN1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:115330	BioGRID:117176	POLA2	BioGRID	PubMed	Two-hybrid
BioGRID:115330	BioGRID:117531	POLDIP2	BioGRID	PubMed	Two-hybrid
BioGRID:115330	BioGRID:111460	PPA1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115330	BioGRID:111495	PPP1CC	BioGRID	PubMed	Affinity Capture-Western; Co-purification; Far Western; Reconstituted Complex
BioGRID:115330	BioGRID:115800	PRDX4	BioGRID	PubMed	Two-hybrid
BioGRID:115330	BioGRID:111564	PRKCA	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:115330	BioGRID:111903	RELB	BioGRID	PubMed	Affinity Capture-MS
BioGRID:115330	BioGRID:107308	RUNX2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115330	BioGRID:116593	SIRT2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115330	BioGRID:110267	SMAD7	BioGRID	PubMed	Affinity Capture-Western
BioGRID:115330	BioGRID:112717	SYK	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:115330	BioGRID:117003	TARDBP	BioGRID	PubMed	Affinity Capture-RNA
BioGRID:115330	BioGRID:116259	TPPP	BioGRID	PubMed	Reconstituted Complex
BioGRID:115330	BioGRID:113603	TUBA1A	BioGRID	PubMed	Biochemical Activity
BioGRID:115330	BioGRID:113131	TUBB2A	BioGRID	PubMed	Biochemical Activity
BioGRID:115330	BioGRID:131483	TUBB2B	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:115330	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BioGRID:115330	BioGRID:115791	UBD	BioGRID	PubMed	Reconstituted Complex
BioGRID:115330	BioGRID:113169	UBE2D1	BioGRID	PubMed	Biochemical Activity
BioGRID:115330	BioGRID:113171	UBE2D3	BioGRID	PubMed	Biochemical Activity
BioGRID:115330	BioGRID:113172	UBE2E1	BioGRID	PubMed	Biochemical Activity
BioGRID:115330	BioGRID:113176	UBE2H	BioGRID	PubMed	Biochemical Activity
BioGRID:115330	BioGRID:113498	ZBTB16	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:115330	BioGRID:113539	ZNF205	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
Hsp90 protein binding	IDA Inferred from Direct Assay more info	PubMed
NAD-dependent histone deacetylase activity (H3-K14 specific)	IEA Inferred from Electronic Annotation more info
NAD-dependent histone deacetylase activity (H3-K9 specific)	IEA Inferred from Electronic Annotation more info
NAD-dependent histone deacetylase activity (H4-K16 specific)	IEA Inferred from Electronic Annotation more info
actin binding	IEA Inferred from Electronic Annotation more info
alpha-tubulin binding	IDA Inferred from Direct Assay more info	PubMed
beta-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
beta-tubulin binding	IEA Inferred from Electronic Annotation more info
dynein complex binding	IDA Inferred from Direct Assay more info	PubMed
enzyme binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
histone deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
histone deacetylase activity (H3-K16 specific)	IEA Inferred from Electronic Annotation more info
histone deacetylase binding	IPI Inferred from Physical Interaction more info	PubMed
hydrolase activity	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
microtubule binding	IDA Inferred from Direct Assay more info	PubMed
microtubule binding	ISS Inferred from Sequence or Structural Similarity more info
polyubiquitin binding	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info
tau protein binding	IDA Inferred from Direct Assay more info	PubMed
tubulin deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
tubulin deacetylase activity	ISS Inferred from Sequence or Structural Similarity more info
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
Hsp90 deacetylation	IMP Inferred from Mutant Phenotype more info	PubMed
aggresome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
cellular response to hydrogen peroxide	IMP Inferred from Mutant Phenotype more info	PubMed
cellular response to misfolded protein	IEA Inferred from Electronic Annotation more info
cellular response to topologically incorrect protein	IMP Inferred from Mutant Phenotype more info	PubMed
chromatin modification	IEA Inferred from Electronic Annotation more info
histone deacetylation	IDA Inferred from Direct Assay more info	PubMed
histone deacetylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
intracellular protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
lysosome localization	IMP Inferred from Mutant Phenotype more info	PubMed
macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
misfolded or incompletely synthesized protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of hydrogen peroxide metabolic process	IC Inferred by Curator more info	PubMed
negative regulation of microtubule depolymerization	IEA Inferred from Electronic Annotation more info
negative regulation of oxidoreductase activity	IC Inferred by Curator more info	PubMed
negative regulation of protein complex disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of proteolysis	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of transcription, DNA-dependent	ISS Inferred from Sequence or Structural Similarity more info	PubMed
peptidyl-lysine deacetylation	IMP Inferred from Mutant Phenotype more info	PubMed
polyubiquitinated misfolded protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of chaperone-mediated protein complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of epithelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of receptor biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
protein deacetylation	IMP Inferred from Mutant Phenotype more info	PubMed
protein polyubiquitination	IEA Inferred from Electronic Annotation more info
regulation of androgen receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
regulation of microtubule-based movement	IC Inferred by Curator more info	PubMed
regulation of receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
response to growth factor stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
response to misfolded protein	IMP Inferred from Mutant Phenotype more info	PubMed
response to organic substance	IMP Inferred from Mutant Phenotype more info	PubMed
response to toxin	IMP Inferred from Mutant Phenotype more info	PubMed
tubulin deacetylation	IDA Inferred from Direct Assay more info	PubMed
tubulin deacetylation	ISS Inferred from Sequence or Structural Similarity more info
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
aggresome	IDA Inferred from Direct Assay more info	PubMed
caveola	IDA Inferred from Direct Assay more info	PubMed
cell leading edge	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
cytoplasmic microtubule	IEA Inferred from Electronic Annotation more info
cytosol	ISS Inferred from Sequence or Structural Similarity more info
colocalizes_with dynein complex	IDA Inferred from Direct Assay more info	PubMed
histone deacetylase complex	IDA Inferred from Direct Assay more info	PubMed
inclusion body	IDA Inferred from Direct Assay more info	PubMed
intracellular	IMP Inferred from Mutant Phenotype more info	PubMed
microtubule	IDA Inferred from Direct Assay more info	PubMed
microtubule associated complex	IDA Inferred from Direct Assay more info	PubMed
NOT nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	ISS Inferred from Sequence or Structural Similarity more info
perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: histone deacetylase 6

Names: histone deacetylase 6

NP_006035.2

EC 3.5.1.98

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012560.1 RefSeqGene

Range

5001..27894

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_006044.2 → NP_006035.2 histone deacetylase 6

Status: REVIEWED

Source sequence(s)

AJ011972

Consensus CDS

CCDS14306.1

UniProtKB/Swiss-Prot

Q9UBN7

Related

ENSP00000334061, OTTHUMP00000032398, ENST00000334136, OTTHUMT00000083394

Conserved Domains (3) summary

pfam09595
Location:891 – 1048
Blast Score: 88

Metaviral_G; Metaviral_G glycoprotein

cl02986
Location:492 – 796
Blast Score: 945

Hist_deacetyl; Histone deacetylase domain

cl09957
Location:1133 – 1195
Blast Score: 234

zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000023.10 Reference GRCh37.p5 Primary Assembly

Range

48660487..48683380

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000155.1 Alternate HuRef

Range

46319662..46343018

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AF196971.2 (21601..44494)	None
genomic	CH471224.1	EAW50744.1
		EAW50745.1
		EAW50746.1
		EAW50747.1
		EAW50748.1
mRNA	AB020708.1	BAA74924.2
mRNA	AF132609.1	AAD29048.1
mRNA	AF174499.1	AAF36540.1
mRNA	AJ011972.1	CAA09893.1
mRNA	AK001543.1	BAG50935.1
mRNA	AK024083.1	BAG51263.1
mRNA	AK095124.1	BAG52988.1
mRNA	AK122954.1	BAG53817.1
mRNA	AK127118.1	None
mRNA	AK131286.1	BAG54760.1
mRNA	AK295884.1	BAG58680.1
mRNA	AK302926.1	BAG64088.1
mRNA	AK303012.1	BAG64143.1
mRNA	AK309058.1	None
mRNA	AL137696.1	CAB70878.2
mRNA	BC005872.1	AAH05872.1
mRNA	BC011498.1	AAH11498.1
mRNA	BC013219.1	None
mRNA	BC013737.1	AAH13737.1
mRNA	BC069243.1	AAH69243.1
mRNA	BT006649.1	AAP35295.1
other-genetic	JF432329.1	ADZ15546.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q6NT75	GenPept	UniProtKB/TrEMBL:Q6NT75
Q7L3E5	GenPept	UniProtKB/TrEMBL:Q7L3E5
Q9BRX7	GenPept	UniProtKB/TrEMBL:Q9BRX7
Q9NSW6	GenPept	UniProtKB/TrEMBL:Q9NSW6
Q9NZS3	GenPept	UniProtKB/TrEMBL:Q9NZS3
Q9UBN7.2	GenPept	UniProtKB/Swiss-Prot:Q9UBN7