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oaz2 ornithine decarboxylase antizyme 2 [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 100127795, updated on 8-Mar-2024

Summary

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Official Symbol
oaz2provided by Xenbase
Official Full Name
ornithine decarboxylase antizyme 2provided by Xenbase
Primary source
Xenbase:XB-GENE-956836
See related
Ensembl:ENSXETG00000010666
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Summary
The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo, however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2014]
Orthologs
human mouse all
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Genomic context

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See oaz2 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
5
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 3 NC_030679.2 (94778575..94799016, complement)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 3 NC_030679.1 (85149730..85169973, complement)

Chromosome 3 - NC_030679.2Genomic Context describing neighboring genes Neighboring gene cytoplasmic polyadenylation element binding protein 1 Neighboring gene adaptor related protein complex 3 subunit beta 2 Neighboring gene RNA binding protein with multiple splicing 2 Neighboring gene uncharacterized LOC116409766 Neighboring gene uncharacterized LOC116409765

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Exploring nervous system transcriptomes during embryogenesis and metamorphosis in Xenopus tropicalis using EST analysis. Fierro AC, et al. BMC Genomics, 2007 May 16. PMID 17506875, Free PMC Article
  2. Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation. Ivanov IP, et al. Nucleic Acids Res, 2007. PMID 17332016, Free PMC Article
  3. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables ornithine decarboxylase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ornithine decarboxylase antizyme 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113112.2 → NP_001106583.3  ornithine decarboxylase antizyme 2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC135959, CN090581, DN009108
    UniProtKB/TrEMBL
    A0A6I8PYA1
    Related
    ENSXETP00000061018.2, ENSXETT00000062096.3
    Conserved Domains (1) summary
    pfam02100
    Location:98 → 181
    ODC_AZ; Ornithine decarboxylase antizyme

  2. NM_001301325.1 → NP_001288254.1  ornithine decarboxylase antizyme 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate, in-frame acceptor splice site at the second exon compared to variant 1. The resulting isoform (2) is one amino acid shorter than isoform 1.
    Source sequence(s)
    BC135959, CN090581, DN009108, EL851728
    UniProtKB/TrEMBL
    A0A8J0QGU1
    Conserved Domains (1) summary
    pfam02100
    Location:97 → 180
    ODC_AZ; Ornithine decarboxylase antizyme

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030679.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    94778575..94799016 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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