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    PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) [ Felis catus (domestic cat) ]

    Gene ID: 100126581, updated on 11-May-2013
    Gene symbol
    PTGS2
    Gene description
    prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Felis catus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
    Location :
    chromosome: F1
    Sequence :
    Chromosome: F1; NC_018739.1 (21510245..21516790)

    Chromosome F1 - NC_018739.1Genomic Context describing neighboring genes Neighboring gene basic transcription factor 3 pseudogene Neighboring gene phospholipase A2, group IVA (cytosolic, calcium-dependent) Neighboring gene chromosome F1 open reading frame, human C1orf27 Neighboring gene phosducin

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Molecular characterization of feline COX-2 and expression in feline mammary carcinomas. Sayasith K, et al. Vet Pathol, 2009 May. PMID 19176489.
    2. COX-1 and COX-2 expression in feline oral squamous cell carcinoma. Hayes A, et al. J Comp Pathol, 2006 Aug-Oct. PMID 16952367.
    3. Activation of p38 MAPK is involved in endothelin-1-stimulated COX-2 expression in cultured Feline esophageal smooth muscle cells. Song HJ, et al. Mol Cells, 2006 Aug 31. PMID 16951549.
    4. COX-2 expression in canine and feline invasive mammary carcinomas: correlation with clinicopathological features and prognostic molecular markers. Millanta F, et al. Breast Cancer Res Treat, 2006 Jul. PMID 16538539.

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The results indicate that COX-1 and COX-2 are overexpressed in feline oral squamous cell carcinoma, but the clinical and pathophysiological significance of this finding remains to be determined .
      Title: COX-1 and COX-2 expression in feline oral squamous cell carcinoma.
    2. COX-2 is expressed in mammary tissues during tumorigenesis in dogs and cats [cyclooxygenase 2]
      Title: COX-2 expression in canine and feline invasive mammary carcinomas: correlation with clinicopathological features and prognostic molecular markers.
    3. ET-1 causes p38 MAPK-dependent expression of esophageal smooth muscle cells COX-2 by interacting with ETB receptors on esophageal smooth muscle cells.
      Title: Activation of p38 MAPK is involved in endothelin-1-stimulated COX-2 expression in cultured Feline esophageal smooth muscle cells.
    Submit: New GeneRIF Correction
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    • Ovarian steroidogenesis, conserved biosystem (from KEGG)
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    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
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      Serotonergic synapse, organism-specific biosystemSerotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endoc...
    • Small cell lung cancer, organism-specific biosystem (from KEGG)
      Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Small cell lung cancer, conserved biosystem (from KEGG)
      Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • VEGF signaling pathway, organism-specific biosystem (from KEGG)
      VEGF signaling pathway, organism-specific biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
    • VEGF signaling pathway, conserved biosystem (from KEGG)
      VEGF signaling pathway, conserved biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
    Preferred Names
    prostaglandin G/H synthase 2
    Names
    prostaglandin G/H synthase 2
    cyclooxygenase 2
    prostaglandin G/H synthase and cyclooxygenase
    NP_001103919.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110449.1 → NP_001103919.1  prostaglandin G/H synthase 2 precursor

      Status: PROVISIONAL

      Source sequence(s)
      EF036473
      UniProtKB/TrEMBL
      A8QIU4
      Conserved Domains (2) summary
      cd00054
      Location:19 – 54
      Blast Score: 93
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd09816
      Location:75 – 562
      Blast Score: 2001
      prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins

    RefSeqs of Annotated Genomes: Felis catus Annotation Release 100

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Felis_catus-6.2 Primary Assembly

    Genomic

    1. NC_018739.1 Reference Felis_catus-6.2 Primary Assembly

      Range
      21510245..21516790
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic AANG02114852.1 (12542..19087) None
    mRNA EF036473.1 ABM65700.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • Taxonomy
        Link to related taxonomy entry

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