CDH3 cadherin 3, type 1, P-cadherin (placental) [Homo sapiens] - Gene

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Summary

Official Symbol: CDH3provided by HGNC
Official Full Name: cadherin 3, type 1, P-cadherin (placental)provided by HGNC
Primary source: HGNC:1762
See related: Ensembl:ENSG00000062038; HPRD:00227; MIM:114021; Vega:OTTHUMG00000137560
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CDHP; HJMD; PCAD
Summary: This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 16q22.1

Sequence :: Chromosome: 16; NC_000016.9 (68678151..68732957)

See CDH3 in Epigenomics, MapViewer

Chromosome 16 - NC_000016.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

High P-cadherin promotes liver metastasis and is associated with colon cancer.
Title: P-cadherin promotes liver metastasis and is associated with poor prognosis in colon cancer.
P-cadherin cooperates with insulin-like growth factor-1 receptor to promote metastatic signaling of gonadotropin-releasing hormone in ovarian cancer via p120 catenin.
Title: P-cadherin cooperates with insulin-like growth factor-1 receptor to promote metastatic signaling of gonadotropin-releasing hormone in ovarian cancer via p120 catenin.
a novel splice site mutation (c.IVS10-1 G --> A) in intron 10, which leads to skipping of exon 11 in CDH3 gene in family with hypotrichosis with juvenile macular dystrophy
Title: A novel splice-acceptor site mutation in CDH3 gene in a consanguineous family exhibiting hypotrichosis with juvenile macular dystrophy.
P-cadherin positivity is associated with high-grade breast cancer subtypes and well-established markers of poor prognosis.
Title: P-cadherin expression as a prognostic biomarker in a 3992 case tissue microarray series of breast cancer.
Stable knockdown of P-cadherin in RT-112 cells diminished invasion and migration, and promoted intercellular adhesion
Title: P-cadherin in adhesion and invasion: opposite roles in colon and bladder carcinoma.
Data conclude that P-cadherin counteracts the expression and function of myosin II-B, resulting in the suppression of the invasive and migratory behaviour of BLM melanoma cells.
Title: P-cadherin counteracts myosin II-B function: implications in melanoma progression.
Observational study of gene-disease association. (HuGE Navigator)
Title: Single nucleotide polymorphisms in the Wnt and BMP pathways and colorectal cancer risk in a Spanish cohort.
P-cadherin and CD24 are expressed in carcinomas of the biliary tract with high frequency and at an early stage of carcinogenesis.
Title: Cell adhesion molecules P-cadherin and CD24 are markers for carcinoma and dysplasia in the biliary tract.
Overexpression of CDH3 is associated with basal-like phenotype in breast cancer.
Title: BRCA1 transcriptionally regulates genes associated with the basal-like phenotype in breast cancer.
Data indicate that P-cadherin but not E-cadherin is important for maintaining adherens junctions in DU145 and MCF10A cells.
Title: p120ctn and P-cadherin but not E-cadherin regulate cell motility and invasion of DU145 prostate cancer cells.

Submit: New GeneRIF Correction See all (43)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Ectodermal dysplasia, ectrodactyly, and macular dystrophy

MIM: 225280

Hypotrichosis, congenital, with juvenile macular dystrophy

MIM: 601553

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Products	Interactant	Other Gene	Source	Pubs	Description
P22223	P22223	CDH3	HPRD	PubMed
P22223	P35221	CTNNA1	HPRD	PubMed
P22223	P35222	CTNNB1	HPRD	PubMed
P22223	O60716	CTNND1	HPRD	PubMed
BioGRID:107436	BioGRID:107434	CDH1	BioGRID	PubMed	Affinity Capture-Western; Co-purification
BioGRID:107436	BioGRID:107436	CDH3	BioGRID	PubMed	Affinity Capture-Western; Co-purification
BioGRID:107436	BioGRID:107876	CTNNA1	BioGRID	PubMed	Affinity Capture-Western; Co-purification
BioGRID:107436	BioGRID:107880	CTNNB1	BioGRID	PubMed	Affinity Capture-Western; Co-purification
BioGRID:107436	BioGRID:107881	CTNND1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107436	BioGRID:109931	JUP	BioGRID	PubMed	Affinity Capture-Western; Co-purification
BioGRID:107436	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Reconstituted Complex

Function	Evidence Code	Pubs
calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
adherens junction organization	TAS Traceable Author Statement more info
cell adhesion	TAS Traceable Author Statement more info	PubMed
cell junction assembly	TAS Traceable Author Statement more info
cell-cell junction organization	TAS Traceable Author Statement more info
homophilic cell adhesion	IEA Inferred from Electronic Annotation more info
response to stimulus	IEA Inferred from Electronic Annotation more info
visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cell-cell adherens junction	IEA Inferred from Electronic Annotation more info
integral to membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	TAS Traceable Author Statement more info

General protein information

Preferred Names: cadherin-3

Names: cadherin-3; calcium-dependent adhesion protein, placental

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_009096.1 RefSeqGene

Range

5001..59807

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001793.4 → NP_001784.2 cadherin-3 preproprotein

Status: REVIEWED

Source sequence(s)

AC099314, AC126773, BC014462, BC041846, BU543746, CA489015, CN365479

Consensus CDS

CCDS10868.1

UniProtKB/Swiss-Prot

P22223

Related

ENSP00000264012, OTTHUMP00000174867, ENST00000264012, OTTHUMT00000268896

Conserved Domains (4) summary

pfam01049
Location:679 – 826
Blast Score: 333

Cadherin_C; Cadherin cytoplasmic region

cd00031
Location:113 – 211
Blast Score: 233

CA_like; Cadherin repeat-like domain.

cd11304
Location:219 – 324
Blast Score: 253

Cadherin_repeat; Cadherin tandem repeat domain.

cl15786
Location:551 – 638
Blast Score: 124

CA_like; Cadherin repeat-like domain.

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000016.9 Reference GRCh37.p5 Primary Assembly

Range

68678151..68732957

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000148.1 Alternate HuRef

Range

54551120..54605916

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC099314.3 (3242..42577)	None
genomic	AC126773.3 (137928..153398)	None
genomic	CH471092.1	EAW83237.1
		EAW83238.1
		EAW83239.1
genomic	CS174724.1	CAJ34555.1
genomic	X95824.1	CAA65093.1
mRNA	AI149268.1	None
mRNA	AK225396.1	None
mRNA	AK296968.1	BAG59512.1
mRNA	AK312554.1	BAG35451.1
mRNA	BC014462.1	AAH14462.1
mRNA	BC041846.1	AAH41846.1
mRNA	BQ945506.1	None
mRNA	BU543746.1	None
mRNA	CA489015.1	None
mRNA	CA489338.1	None
mRNA	CA489357.1	None
mRNA	CN365479.1	None
mRNA	X63629.1	CAA45177.1
other-genetic	EU832319.1	ACE87576.1
other-genetic	EU832404.1	ACE86889.1