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ZBTB33 zinc finger and BTB domain containing 33 [ Homo sapiens (human) ]

Gene ID: 10009, updated on 8-May-2016
Official Symbol
ZBTB33provided by HGNC
Official Full Name
zinc finger and BTB domain containing 33provided by HGNC
Primary source
HGNC:HGNC:16682
See related
Ensembl:ENSG00000177485 HPRD:02269; MIM:300329; Vega:OTTHUMG00000171159
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF348; ZNF-kaiso
Summary
This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.[provided by RefSeq, May 2010]
Orthologs
Location:
Xq23
Exon count:
3
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) X NC_000023.11 (120250752..120258396)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (119384607..119392251)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 30 Neighboring gene NFKB activating protein pseudogene 1 Neighboring gene transmembrane protein 255A Neighboring gene ATPase Na+/K+ transporting family member beta 4 Neighboring gene uncharacterized LOC105373326 Neighboring gene lysosomal associated membrane protein 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
    Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell plurip...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
methyl-CpG binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction TAS
Traceable Author Statement
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
Preferred Names
transcriptional regulator Kaiso
Names
WUGSC:H_DJ525N14.1
kaiso transcription factor
zinc finger and BTB domain-containing protein 33

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021334.1 RefSeqGene

    Range
    5001..12645
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184742.1NP_001171671.1  transcriptional regulator Kaiso

    See identical proteins and their annotated locations for NP_001171671.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK312321, BC042753, DB468333
    Consensus CDS
    CCDS14596.1
    UniProtKB/Swiss-Prot
    Q86T24
    Related
    ENSP00000450969, OTTHUMP00000255478, ENST00000557385, OTTHUMT00000434468
    Conserved Domains (3) summary
    pfam00651
    Location:22116
    BTB; BTB/POZ domain
    pfam13465
    Location:508531
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:496516
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_006777.3NP_006768.1  transcriptional regulator Kaiso

    See identical proteins and their annotated locations for NP_006768.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' UTR, as compared to variant 1.
    Source sequence(s)
    BC042753, BX538016, BX538101
    Consensus CDS
    CCDS14596.1
    UniProtKB/Swiss-Prot
    Q86T24
    Related
    ENSP00000314153, OTTHUMP00000023933, ENST00000326624, OTTHUMT00000058085
    Conserved Domains (3) summary
    pfam00651
    Location:22116
    BTB; BTB/POZ domain
    pfam13465
    Location:508531
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:496516
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p2 Primary Assembly

    Range
    120250752..120258396
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018934.2 Alternate CHM1_1.1

    Range
    119295897..119303542
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)