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UNC13A unc-13 homolog A [ Ornithorhynchus anatinus (platypus) ]

Gene ID: 100076365, updated on 8-Mar-2024

Summary

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Gene symbol
UNC13A
Gene description
unc-13 homolog A
See related
Ensembl:ENSOANG00000037185
Gene type
protein coding
RefSeq status
MODEL
Organism
Ornithorhynchus anatinus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: X2
Exon count:
46
Annotation release Status Assembly Chr Location
105 current mOrnAna1.pri.v4 (GCF_004115215.2) X2 NC_041750.1 (11684593..11768103)

Chromosome X2 - NC_041750.1Genomic Context describing neighboring genes Neighboring gene small integral membrane protein 24 Neighboring gene nuclear factor I C Neighboring gene uncharacterized LOC120638098 Neighboring gene mex-3 RNA binding family member D

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_041750.1 Chromosome X2 Reference mOrnAna1.pri.v4 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables diacylglycerol binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phospholipid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables syntaxin-1 binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in dense core granule priming IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neuromuscular junction development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in presynaptic dense core vesicle exocytosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in synaptic transmission, glutamatergic IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in synaptic vesicle docking IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in synaptic vesicle maturation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in synaptic vesicle priming IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in neuromuscular junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in presynaptic active zone cytoplasmic component IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in terminal bouton IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
protein unc-13 homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Ornithorhynchus anatinus Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mOrnAna1.pri.v4 Primary Assembly

Genomic

  1. NC_041750.1 Reference mOrnAna1.pri.v4 Primary Assembly

    Range
    11684593..11768103
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_029053199.2 → XP_028909032.1  protein unc-13 homolog A isoform X1

    UniProtKB/TrEMBL
    A0A6I8NGH5
    Conserved Domains (7) summary
    cd04027
    Location:703 → 829
    C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
    cd08394
    Location:1 → 127
    C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins
    cd08395
    Location:1592 → 1711
    C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
    cd00029
    Location:581 → 630
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam06292
    Location:1021 → 1129
    DUF1041; Domain of Unknown Function (DUF1041)
    pfam10540
    Location:1373 → 1535
    Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
    NF000535
    Location:181 → 350
    MSCRAMM_SdrC; MSCRAMM family adhesin SdrC

  2. XM_029053202.2 → XP_028909035.1  protein unc-13 homolog A isoform X4

    UniProtKB/TrEMBL
    A0A6I8NGH5
    Related
    ENSOANP00000043869.1
    Conserved Domains (7) summary
    cd04027
    Location:703 → 829
    C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
    cd08394
    Location:1 → 127
    C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins
    cd08395
    Location:1573 → 1692
    C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
    cd00029
    Location:581 → 630
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam06292
    Location:1021 → 1129
    DUF1041; Domain of Unknown Function (DUF1041)
    pfam10540
    Location:1373 → 1535
    Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
    NF000535
    Location:181 → 350
    MSCRAMM_SdrC; MSCRAMM family adhesin SdrC

  3. XM_029053203.2 → XP_028909036.1  protein unc-13 homolog A isoform X6

    UniProtKB/TrEMBL
    A0A6I8NGH5
    Conserved Domains (7) summary
    cd04027
    Location:703 → 829
    C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
    cd08394
    Location:1 → 127
    C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins
    cd08395
    Location:1569 → 1688
    C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
    cd00029
    Location:581 → 630
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam06292
    Location:1021 → 1129
    DUF1041; Domain of Unknown Function (DUF1041)
    pfam10540
    Location:1373 → 1512
    Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
    NF000535
    Location:181 → 350
    MSCRAMM_SdrC; MSCRAMM family adhesin SdrC

  4. XM_029053200.2 → XP_028909033.1  protein unc-13 homolog A isoform X2

    UniProtKB/TrEMBL
    A0A6I8NGH5
    Related
    ENSOANP00000039816.1
    Conserved Domains (7) summary
    cd04027
    Location:703 → 829
    C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
    cd08394
    Location:1 → 127
    C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins
    cd08395
    Location:1590 → 1709
    C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
    cd00029
    Location:581 → 630
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam06292
    Location:1021 → 1129
    DUF1041; Domain of Unknown Function (DUF1041)
    pfam10540
    Location:1373 → 1533
    Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
    NF000535
    Location:181 → 350
    MSCRAMM_SdrC; MSCRAMM family adhesin SdrC

  5. XM_039910495.1 → XP_039766429.1  protein unc-13 homolog A isoform X5

    UniProtKB/TrEMBL
    A0A6I8NGH5
    Conserved Domains (5) summary
    cd04027
    Location:703 → 829
    C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
    cd08394
    Location:1 → 127
    C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins
    cd08395
    Location:1571 → 1690
    C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
    smart00109
    Location:581 → 630
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    NF000535
    Location:181 → 350
    MSCRAMM_SdrC; MSCRAMM family adhesin SdrC

  6. XM_029053204.2 → XP_028909037.1  protein unc-13 homolog A isoform X7

    UniProtKB/TrEMBL
    A0A6I8PF60
    Related
    ENSOANP00000051241.1
    Conserved Domains (7) summary
    cd04027
    Location:667 → 793
    C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
    cd08394
    Location:1 → 127
    C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins
    cd08395
    Location:1556 → 1675
    C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
    cd00029
    Location:545 → 594
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam06292
    Location:985 → 1093
    DUF1041; Domain of Unknown Function (DUF1041)
    pfam10540
    Location:1337 → 1499
    Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
    NF000535
    Location:181 → 314
    MSCRAMM_SdrC; MSCRAMM family adhesin SdrC

  7. XM_029053205.2 → XP_028909038.1  protein unc-13 homolog A isoform X8

    UniProtKB/TrEMBL
    A0A6I8PF60
    Conserved Domains (7) summary
    cd04027
    Location:667 → 793
    C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
    cd08394
    Location:1 → 127
    C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins
    cd08395
    Location:1537 → 1656
    C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
    cd00029
    Location:545 → 594
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam06292
    Location:985 → 1093
    DUF1041; Domain of Unknown Function (DUF1041)
    pfam10540
    Location:1337 → 1499
    Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
    NF000535
    Location:181 → 314
    MSCRAMM_SdrC; MSCRAMM family adhesin SdrC

  8. XM_039910496.1 → XP_039766430.1  protein unc-13 homolog A isoform X9

    UniProtKB/TrEMBL
    A0A6I8PF60
    Conserved Domains (5) summary
    cd04027
    Location:667 → 793
    C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
    cd08394
    Location:1 → 127
    C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins
    cd08395
    Location:1535 → 1654
    C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
    smart00109
    Location:545 → 594
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    NF000535
    Location:181 → 314
    MSCRAMM_SdrC; MSCRAMM family adhesin SdrC

  9. XM_029053201.2 → XP_028909034.1  protein unc-13 homolog A isoform X3

    UniProtKB/TrEMBL
    A0A6I8NGH5
    Related
    ENSOANP00000045648.1
    Conserved Domains (7) summary
    cd04027
    Location:691 → 817
    C2B_Munc13; C2 domain second repeat in Munc13 (mammalian uncoordinated) proteins
    cd08394
    Location:1 → 127
    C2A_Munc13; C2 domain first repeat in Munc13 (mammalian uncoordinated) proteins
    cd08395
    Location:1580 → 1699
    C2C_Munc13; C2 domain third repeat in Munc13 (mammalian uncoordinated) proteins
    cd00029
    Location:569 → 618
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam06292
    Location:1009 → 1117
    DUF1041; Domain of Unknown Function (DUF1041)
    pfam10540
    Location:1361 → 1523
    Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
    NF000535
    Location:153 → 338
    MSCRAMM_SdrC; MSCRAMM family adhesin SdrC
Nucleotide Protein
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