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GNPDA1 glucosamine-6-phosphate deaminase 1 [ Homo sapiens (human) ]

Gene ID: 10007, updated on 8-May-2016
Official Symbol
GNPDA1provided by HGNC
Official Full Name
glucosamine-6-phosphate deaminase 1provided by HGNC
Primary source
HGNC:HGNC:4417
See related
Ensembl:ENSG00000113552 HPRD:09048; MIM:601798; Vega:OTTHUMG00000129657
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPI; HLN; GNP1; GNPI; GNPDA
Summary
Glucosamine-6-phosphate deaminase (EC 3.5.99.6) is an allosteric enzyme that catalyzes the reversible conversion of D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium (Arreola et al., 2003 [PubMed 12965206]).[supplied by OMIM, Jan 2010]
Orthologs
Location:
5q21
Exon count:
9
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 5 NC_000005.10 (142000669..142013055, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (141380234..141392620, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378203 Neighboring gene protocadherin 12 Neighboring gene ring finger protein 14 Neighboring gene mitochondrial ribosomal protein L11 pseudogene 2 Neighboring gene uncharacterized LOC105378204

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0060

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glucosamine-6-phosphate deaminase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucosamine-6-phosphate deaminase activity TAS
Traceable Author Statement
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
N-acetylglucosamine metabolic process IEA
Inferred from Electronic Annotation
more info
 
generation of precursor metabolites and energy IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucosamine catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucose metabolic process TAS
Traceable Author Statement
more info
 
single fertilization TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
glucosamine-6-phosphate isomerase 1
Names
GNPDA 1
glcN6P deaminase 1
oscillin
NP_005462.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005471.4NP_005462.1  glucosamine-6-phosphate isomerase 1

    See identical proteins and their annotated locations for NP_005462.1

    Status: VALIDATED

    Source sequence(s)
    AC005740, BC022322, CA432951, DA661926
    Consensus CDS
    CCDS4272.1
    UniProtKB/Swiss-Prot
    P46926
    Related
    ENSP00000311876, OTTHUMP00000160062, ENST00000311337, OTTHUMT00000251857
    Conserved Domains (1) summary
    cd01399
    Location:11247
    GlcN6P_deaminase; GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p2 Primary Assembly

    Range
    142000669..142013055 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714747.2XP_006714810.1  

    See identical proteins and their annotated locations for XP_006714810.1

    UniProtKB/Swiss-Prot
    P46926
    Related
    ENSP00000424275, OTTHUMP00000222767, ENST00000500692, OTTHUMT00000370630
    Conserved Domains (1) summary
    cd01399
    Location:11247
    GlcN6P_deaminase; GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or ...
  2. XM_011537537.1XP_011535839.1  

    See identical proteins and their annotated locations for XP_011535839.1

    UniProtKB/Swiss-Prot
    P46926
    Related
    ENSP00000423485, OTTHUMP00000222769, ENST00000503794, OTTHUMT00000370632
    Conserved Domains (1) summary
    cd01399
    Location:11247
    GlcN6P_deaminase; GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or ...
  3. XM_005268348.1XP_005268405.1  

    Conserved Domains (1) summary
    cd01399
    Location:40276
    GlcN6P_deaminase; GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or ...

Alternate CHM1_1.1

Genomic

  1. NC_018916.2 Alternate CHM1_1.1

    Range
    140813651..140826030 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)