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MAP2K5 mitogen-activated protein kinase kinase 5 [ Equus caballus (horse) ]

Gene ID: 100052849, updated on 8-Mar-2024

Summary

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Official Symbol
MAP2K5provided by VGNC
Official Full Name
mitogen-activated protein kinase kinase 5provided by VGNC
Primary source
VGNC:VGNC:19928
See related
Ensembl:ENSECAG00000022411
Gene type
protein coding
RefSeq status
MODEL
Organism
Equus caballus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
28
Annotation release Status Assembly Chr Location
103 current EquCab3.0 (GCF_002863925.1) 1 NC_009144.3 (126103597..126348606, complement)
102 previous assembly EquCab2.0 (GCF_000002305.2) 1 NC_009144.2 (124955633..125200605, complement)

Chromosome 1 - NC_009144.3Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC111776029 Neighboring gene SKI family transcriptional corepressor 1 Neighboring gene chromosome 1 C15orf61 homolog Neighboring gene IQ motif containing H Neighboring gene uncharacterized LOC111776089

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
dual specificity mitogen-activated protein kinase kinase 5

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Equus caballus Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference EquCab3.0 Primary Assembly

Genomic

  1. NC_009144.3 Reference EquCab3.0 Primary Assembly

    Range
    126103597..126348606 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023654952.1 → XP_023510720.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X12

    UniProtKB/TrEMBL
    F7BQY5
    Conserved Domains (2) summary
    cd06395
    Location:17 → 107
    PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
    cl21453
    Location:164 → 412
    PKc_like; Protein Kinases, catalytic domain

  2. XM_023654972.1 → XP_023510740.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X20

    UniProtKB/TrEMBL
    F7BQY5
    Conserved Domains (2) summary
    cd06395
    Location:17 → 107
    PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
    cl21453
    Location:164 → 359
    PKc_like; Protein Kinases, catalytic domain

  3. XM_001496625.5 → XP_001496675.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X10

    UniProtKB/TrEMBL
    A0A3Q2HWX2
    Conserved Domains (3) summary
    cd06395
    Location:17 → 107
    PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
    cd06619
    Location:164 → 432
    PKc_MKK5; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5
    smart00220
    Location:170 → 409
    S_TKc; Serine/Threonine protein kinases, catalytic domain

  4. XM_023654969.1 → XP_023510737.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X18

    UniProtKB/TrEMBL
    F7BQY5
    Conserved Domains (2) summary
    cd06395
    Location:17 → 107
    PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
    cl21453
    Location:164 → 369
    PKc_like; Protein Kinases, catalytic domain

  5. XM_005602976.3 → XP_005603033.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X9

    UniProtKB/TrEMBL
    A0A3Q2HWX2
    Related
    ENSECAP00000063517.1, ENSECAT00000085160.1
    Conserved Domains (3) summary
    cd06395
    Location:17 → 107
    PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
    cd06619
    Location:164 → 433
    PKc_MKK5; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5
    smart00220
    Location:170 → 410
    S_TKc; Serine/Threonine protein kinases, catalytic domain

  6. XM_014733756.2 → XP_014589242.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X16

    UniProtKB/TrEMBL
    F7BQY5
    Conserved Domains (2) summary
    cd06395
    Location:17 → 107
    PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
    cl21453
    Location:164 → 378
    PKc_like; Protein Kinases, catalytic domain

  7. XM_001496608.5 → XP_001496658.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X8

    UniProtKB/TrEMBL
    A0A3Q2HWX2
    Related
    ENSECAP00000037846.3, ENSECAT00000053838.3
    Conserved Domains (3) summary
    cd06395
    Location:17 → 107
    PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
    cd06619
    Location:164 → 442
    PKc_MKK5; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5
    smart00220
    Location:170 → 419
    S_TKc; Serine/Threonine protein kinases, catalytic domain

  8. XM_023654960.1 → XP_023510728.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X14

    UniProtKB/TrEMBL
    F7BQY5
    Conserved Domains (2) summary
    cd06395
    Location:17 → 107
    PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
    cl21453
    Location:164 → 348
    PKc_like; Protein Kinases, catalytic domain

  9. XM_023654950.1 → XP_023510718.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X11

    UniProtKB/TrEMBL
    A0A3Q2HWX2
    Conserved Domains (2) summary
    cd06395
    Location:17 → 107
    PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
    cl21453
    Location:164 → 422
    PKc_like; Protein Kinases, catalytic domain

  10. XM_023654953.1 → XP_023510721.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X13

    UniProtKB/TrEMBL
    F7BQY5
    Conserved Domains (2) summary
    cd06395
    Location:17 → 107
    PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
    cl21453
    Location:164 → 348
    PKc_like; Protein Kinases, catalytic domain

  11. XM_023654942.1 → XP_023510710.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X6

    UniProtKB/TrEMBL
    A0A9L0SE88
    Conserved Domains (2) summary
    cd06395
    Location:17 → 107
    PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
    cd06619
    Location:164 → 476
    PKc_MKK5; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5

  12. XM_023654955.1 → XP_023510723.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X13

    UniProtKB/TrEMBL
    F7BQY5
    Conserved Domains (2) summary
    cd06395
    Location:17 → 107
    PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
    cl21453
    Location:164 → 348
    PKc_like; Protein Kinases, catalytic domain

  13. XM_023654948.1 → XP_023510716.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X7

    UniProtKB/TrEMBL
    A0A9L0RNW5
    Conserved Domains (2) summary
    cd06395
    Location:17 → 107
    PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
    cl21453
    Location:164 → 384
    PKc_like; Protein Kinases, catalytic domain

  14. XM_014733755.2 → XP_014589241.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X5

    UniProtKB/TrEMBL
    A0A9L0RNW5, A0A9L0SIQ6
    Related
    ENSECAP00000074798.1, ENSECAT00000115541.1
    Conserved Domains (3) summary
    cd06395
    Location:17 → 107
    PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
    smart00220
    Location:170 → 395
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:164 → 394
    PKc_like; Protein Kinases, catalytic domain

  15. XM_023654936.1 → XP_023510704.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X4

    UniProtKB/TrEMBL
    A0A3Q2HJH1, A0A9L0RNW5
    Related
    ENSECAP00000033367.2, ENSECAT00000062364.2
    Conserved Domains (2) summary
    cd06395
    Location:17 → 107
    PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
    cl21453
    Location:164 → 395
    PKc_like; Protein Kinases, catalytic domain

  16. XM_014733753.2 → XP_014589239.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X2

    UniProtKB/TrEMBL
    A0A3Q2HX30, A0A9L0RNW5
    Related
    ENSECAP00000039004.1, ENSECAT00000060995.2
    Conserved Domains (3) summary
    cd06395
    Location:17 → 107
    PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
    smart00220
    Location:170 → 406
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:164 → 405
    PKc_like; Protein Kinases, catalytic domain

  17. XM_014733754.2 → XP_014589240.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X3

    UniProtKB/TrEMBL
    A0A9L0RNW5
    Conserved Domains (3) summary
    cd06395
    Location:17 → 107
    PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
    smart00220
    Location:170 → 405
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:164 → 404
    PKc_like; Protein Kinases, catalytic domain

  18. XM_014733752.2 → XP_014589238.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X1

    UniProtKB/TrEMBL
    A0A3Q2HUG4, A0A9L0RNW5
    Related
    ENSECAP00000036956.1, ENSECAT00000061163.2
    Conserved Domains (3) summary
    cd06395
    Location:17 → 107
    PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
    smart00220
    Location:170 → 415
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:164 → 414
    PKc_like; Protein Kinases, catalytic domain

  19. XM_023654958.1 → XP_023510726.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X13

    UniProtKB/TrEMBL
    F7BQY5
    Conserved Domains (2) summary
    cd06395
    Location:17 → 107
    PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
    cl21453
    Location:164 → 348
    PKc_like; Protein Kinases, catalytic domain

  20. XM_023654971.1 → XP_023510739.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X19

    UniProtKB/TrEMBL
    F7BQY5
    Conserved Domains (2) summary
    cd06395
    Location:17 → 107
    PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
    cl21453
    Location:164 → 371
    PKc_like; Protein Kinases, catalytic domain

  21. XM_023654964.1 → XP_023510732.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X17

    UniProtKB/TrEMBL
    F7BQY5
    Conserved Domains (2) summary
    cd06395
    Location:17 → 107
    PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
    cl21453
    Location:164 → 359
    PKc_like; Protein Kinases, catalytic domain

  22. XM_023654961.1 → XP_023510729.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X15

    UniProtKB/TrEMBL
    A0A9L0SE88
    Conserved Domains (2) summary
    cd06395
    Location:17 → 107
    PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
    cl21453
    Location:164 → 348
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_002812087.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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