EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 [Monodelphis domestica (gray short-tailed opossum)] - Gene

Summary

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Gene symbol: EIF2AK4
Gene description: eukaryotic translation initiation factor 2 alpha kinase 4
Gene type: protein coding
RefSeq status: MODEL
Organism: Monodelphis domestica
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis

Genomic context

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Location :: chromosome: 1

Sequence :: Chromosome: 1; NC_008801.1 (196267548..196400092)

See EIF2AK4 in MapViewer

Chromosome 1 - NC_008801.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

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Pathways from BioSystems

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Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
Epstein-Barr virus infection, conserved biosystem (from KEGG)
Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
Hepatitis C, organism-specific biosystem (from KEGG)
Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
Hepatitis C, conserved biosystem (from KEGG)
Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
Herpes simplex infection, organism-specific biosystem (from KEGG)
Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
Herpes simplex infection, conserved biosystem (from KEGG)
Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
Influenza A, organism-specific biosystem (from KEGG)
Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
Influenza A, conserved biosystem (from KEGG)
Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
Measles, organism-specific biosystem (from KEGG)
Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
Measles, conserved biosystem (from KEGG)
Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...

General gene information

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Homology

OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

General protein information

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Names: eukaryotic translation initiation factor 2 alpha kinase 4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Build 2.2

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference MonDom5 Primary Assembly

Genomic

NC_008801.1

Range

196267548..196400092

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_001380935.2 → XP_001380972.1

Conserved Domains (7) summary

cd00859
Location:1413 – 1504
Blast Score: 130

HisRS_anticodon; HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...

COG0124
Location:1078 – 1507
Blast Score: 349

HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

cd00180
Location:813 – 1009
Blast Score: 340

PKc; Catalytic domain of Protein Kinases

smart00220
Location:812 – 1009
Blast Score: 389

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam05773
Location:34 – 148
Blast Score: 273

RWD; RWD domain

cl00268
Location:1078 – 1261
Blast Score: 246

class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...

cl09925
Location:343 – 560
Blast Score: 367

PKc_like; Protein Kinases, catalytic domain

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AAFR03021893.1 (26488..130267)	None
genomic	AAFR03021894.1	None
genomic	AAFR03021895.1	None
genomic	AAFR03021896.1	None