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HECTD1 HECT domain E3 ubiquitin protein ligase 1 [ Monodelphis domestica (gray short-tailed opossum) ]

Gene ID: 100012904, updated on 8-Mar-2024

Summary

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Gene symbol
HECTD1
Gene description
HECT domain E3 ubiquitin protein ligase 1
See related
Ensembl:ENSMODG00000017590
Gene type
protein coding
RefSeq status
MODEL
Organism
Monodelphis domestica
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
44
Annotation release Status Assembly Chr Location
RS_2023_05 current mMonDom1.pri (GCF_027887165.1) 1 NC_077227.1 (213763126..213874683)
103 previous assembly MonDom5 (GCF_000002295.2) 1 NC_008801.1 (208178605..208289978)

Chromosome 1 - NC_077227.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene HEAT repeat containing 5A Neighboring gene adaptor related protein complex 4 subunit sigma 1 Neighboring gene eukaryotic translation initiation factor 5A-1-like Neighboring gene striatin 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in anatomical structure development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein K63-linked ubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase HECTD1
Names
HECT domain containing 1
HECT domain containing E3 ubiquitin protein ligase 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_027887165.1-RS_2023_05

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mMonDom1.pri

Genomic

  1. NC_077227.1 Reference mMonDom1.pri

    Range
    213763126..213874683
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001364054.5 → XP_001364091.1  E3 ubiquitin-protein ligase HECTD1 isoform X1

    UniProtKB/TrEMBL
    F7B4N3
    Related
    ENSMODP00000021945.3
    Conserved Domains (7) summary
    smart00119
    Location:2155 → 2607
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:2131 → 2608
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00204
    Location:369 → 479
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam06701
    Location:1277 → 1335
    MIB_HERC2; Mib_herc2
    pfam12796
    Location:366 → 457
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:396 → 426
    ANK; ANK repeat [structural motif]
    cl23730
    Location:1107 → 1240
    F5_F8_type_C; F5/8 type C domain

  2. XM_007472523.3 → XP_007472585.1  E3 ubiquitin-protein ligase HECTD1 isoform X2

    Conserved Domains (7) summary
    smart00119
    Location:2143 → 2595
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:2119 → 2596
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00204
    Location:369 → 479
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam06701
    Location:1277 → 1335
    MIB_HERC2; Mib_herc2
    pfam12796
    Location:366 → 457
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:396 → 426
    ANK; ANK repeat [structural motif]
    cl23730
    Location:1107 → 1240
    F5_F8_type_C; F5/8 type C domain

  3. XM_007472524.3 → XP_007472586.1  E3 ubiquitin-protein ligase HECTD1 isoform X3

    Conserved Domains (7) summary
    smart00119
    Location:2108 → 2560
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:2084 → 2561
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00204
    Location:369 → 479
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam06701
    Location:1277 → 1321
    MIB_HERC2; Mib_herc2
    pfam12796
    Location:366 → 457
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:396 → 426
    ANK; ANK repeat [structural motif]
    cl23730
    Location:1107 → 1240
    F5_F8_type_C; F5/8 type C domain

  4. XM_056810421.1 → XP_056666399.1  E3 ubiquitin-protein ligase HECTD1 isoform X4

    UniProtKB/TrEMBL
    A0A5F8G9H7

  5. XM_056810419.1 → XP_056666397.1  E3 ubiquitin-protein ligase HECTD1 isoform X2

  6. XM_056810418.1 → XP_056666396.1  E3 ubiquitin-protein ligase HECTD1 isoform X1

    UniProtKB/TrEMBL
    F7B4N3

  7. XM_056810420.1 → XP_056666398.1  E3 ubiquitin-protein ligase HECTD1 isoform X3

  8. XM_056810422.1 → XP_056666400.1  E3 ubiquitin-protein ligase HECTD1 isoform X5

  9. XM_056810423.1 → XP_056666401.1  E3 ubiquitin-protein ligase HECTD1 isoform X6

  10. XM_056810424.1 → XP_056666402.1  E3 ubiquitin-protein ligase HECTD1 isoform X7

  11. XM_056810425.1 → XP_056666403.1  E3 ubiquitin-protein ligase HECTD1 isoform X8

Nucleotide Protein
Heading Accession and Version

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