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MED6 mediator complex subunit 6 [ Homo sapiens (human) ]

Gene ID: 10001, updated on 25-Jul-2014
Official Symbol
MED6provided by HGNC
Official Full Name
mediator complex subunit 6provided by HGNC
Primary source
HGNC:19970
See related
Ensembl:ENSG00000133997; HPRD:04284; MIM:602984; Vega:OTTHUMG00000171252
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARC33; NY-REN-28
See MED6 in Epigenomics
Location:
14q24.2
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 14 NC_000014.9 (70583221..70600690, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (71050306..71067401, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase domain 20 Neighboring gene ADAM metallopeptidase domain 20 pseudogene Neighboring gene double homeobox A pseudogene Neighboring gene keratin 18 pseudogene 7 Neighboring gene uncharacterized LOC101928075 Neighboring gene tetratricopeptide repeat domain 9

Replication interactions

Interaction Pubs
Knockdown of mediator complex subunit 6 (MED6) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed
Knockdown of mediator complex subunit 6 (MED6) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed
Knockdown of mediator complex subunit 6 (MED6) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat The interaction of HIV-1 Tat with MED21 hypothetically induces the binding of Tat to MED6 PubMed
tat Knockdown of MED6 by siRNAs inhibits HIV LTR-beta-gal activation in the Tat transactivation assay PubMed

Go to the HIV-1, Human Protein Interaction Database

  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
    Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • PPARA activates gene expression, organism-specific biosystem (from REACTOME)
    PPARA activates gene expression, organism-specific biosystemThe set of genes regulated by PPAR-alpha is not fully known in humans, however many examples have been found in mice. Genes directly activated by PPAR-alpha contain peroxisome proliferator receptor e...
  • Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem (from REACTOME)
    Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystemPeroxisome proliferator-activated receptor alpha (PPAR-alpha) is the major regulator of fatty acid oxidation in the liver. PPARalpha is also the target of fibrate drugs used to treat abnormal plasma ...
  • Transcriptional regulation of white adipocyte differentiation, organism-specific biosystem (from REACTOME)
    Transcriptional regulation of white adipocyte differentiation, organism-specific biosystemAdipogenesis is the process of cell differentiation by which preadipocytes become adipocytes. During this process the preadipocytes cease to proliferate, begin to accumulate lipid droplets and develo...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II transcription cofactor activity IEA
Inferred from Electronic Annotation
more info
 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
mediator complex IDA
Inferred from Direct Assay
more info
PubMed 
mediator complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
mediator of RNA polymerase II transcription subunit 6
Names
mediator of RNA polymerase II transcription subunit 6
CTD-2540L5.5
renal carcinoma antigen NY-REN-28
activator-recruited cofactor 33 kDa component

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284209.1NP_001271138.1  mediator of RNA polymerase II transcription subunit 6 isoform 1

    See proteins identical to NP_001271138.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AK300460, BM999935, DA869309, HY064772
    Consensus CDS
    CCDS61484.1
    UniProtKB/Swiss-Prot
    O75586
    Conserved Domains (1) summary
    pfam04934
    Location:13148
    Blast Score: 475
    Med6; MED6 mediator sub complex component
  2. NM_001284210.1NP_001271139.1  mediator of RNA polymerase II transcription subunit 6 isoform 3

    See proteins identical to NP_001271139.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site and lacks an alternate exon in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK300460, AK304361, BM999935, DA869309, HY064772
    Consensus CDS
    CCDS61483.1
    UniProtKB/Swiss-Prot
    O75586
    Conserved Domains (1) summary
    pfam04934
    Location:13141
    Blast Score: 488
    Med6; MED6 mediator sub complex component
  3. NM_001284211.1NP_001271140.1  mediator of RNA polymerase II transcription subunit 6 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site and differs in the 3' exon structure, which results in a frameshift, compared to variant 1. The encoded isoform (4) is longer and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK300460, BM802752, BM999935, DA869309, HY064772
    UniProtKB/Swiss-Prot
    O75586
    Conserved Domains (1) summary
    pfam04934
    Location:13141
    Blast Score: 493
    Med6; MED6 mediator sub complex component
  4. NM_005466.3NP_005457.2  mediator of RNA polymerase II transcription subunit 6 isoform 2

    See proteins identical to NP_005457.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL357153, BC004106, BM999935, DA869309, HY064772
    Consensus CDS
    CCDS9805.1
    UniProtKB/Swiss-Prot
    O75586
    Related
    ENSP00000413343, OTTHUMP00000245584, ENST00000430055, OTTHUMT00000412561
    Conserved Domains (1) summary
    pfam04934
    Location:13141
    Blast Score: 496
    Med6; MED6 mediator sub complex component

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000014.9 

    Range
    70583221..70600690
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000146.1 

    Range
    51218589..51236062
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018925.2 

    Range
    70988125..71005597
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)