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defbl3 defensin, beta-like 3 [ Danio rerio (zebrafish) ]

Gene ID: 100009621, updated on 27-Mar-2024

Summary

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Official Symbol
defbl3provided by ZNC
Official Full Name
defensin, beta-like 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-070207-3
See related
Ensembl:ENSDARG00000097181 AllianceGenome:ZFIN:ZDB-GENE-070207-3
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
db-3
Summary
Predicted to be involved in defense response to bacterium. Predicted to act upstream of or within innate immune response. Predicted to be located in extracellular region. Is expressed in digestive system; gill; integument; muscle cell; and pleuroperitoneal region. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 15
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (5011080..5016039, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (5019933..5025575, complement)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene lipoyl(octanoyl) transferase 2 Neighboring gene ring finger protein 169 Neighboring gene signal peptidase complex subunit 2 Neighboring gene ATP-binding cassette, sub-family G (WHITE), member 1 Neighboring gene myxovirus (influenza virus) resistance F

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Molecular cloning and expression analysis of two β-defensin genes in the blunt snout bream (Megalobrama amblycephala). Liang T, et al. Comp Biochem Physiol B Biochem Mol Biol, 2013 Sep. PMID 23876385
  2. Discovery of multiple beta-defensin like homologues in teleost fish. Zou J, et al. Mol Immunol, 2007 Jan. PMID 16540171
  3. Pathogen invasion changes the intestinal microbiota composition and induces innate immune responses in the zebrafish intestine. Yang HT, et al. Fish Shellfish Immunol, 2017 Dec. PMID 28964859
  4. Role of intestinal inflammation in predisposition of Edwardsiella tarda infection in zebrafish (Danio rerio). Liu X, et al. Fish Shellfish Immunol, 2014 Dec. PMID 25224880
  5. Th17-like immune response in fish mucosal tissues after administration of live attenuated Vibrio anguillarum via different vaccination routes. Zhang H, et al. Fish Shellfish Immunol, 2014 Apr. PMID 24561130

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within defense response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within defense response to bacterium IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
beta-defensin-like 3
Names
BD-3
defensin-like protein 3
zfdb-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081555.1 → NP_001075024.1  beta-defensin-like 3 precursor

    See identical proteins and their annotated locations for NP_001075024.1

    Status: PROVISIONAL

    Source sequence(s)
    AM181360
    UniProtKB/TrEMBL
    A0A8M1ND15, A1IVN1
    Related
    ENSDARP00000129545.1, ENSDART00000156458.2

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    5011080..5016039 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases