U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MMP9 matrix metallopeptidase 9 [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100008993, updated on 8-Mar-2024

Summary

Go to the top of the page Help
Gene symbol
MMP9
Gene description
matrix metallopeptidase 9
See related
Ensembl:ENSOCUG00000016101
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 4
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) 4 NC_067377.1 (2788510..2795456, complement)

Chromosome 4 - NC_067377.1Genomic Context describing neighboring genes Neighboring gene nuclear receptor coactivator 5 Neighboring gene solute carrier family 12 member 5 Neighboring gene zinc finger protein 335 Neighboring gene phosphorylated CTD interacting factor 1

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_067377.1 Chromosome 4 Reference UM_NZW_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Macrophage-derived MMP-9 enhances the progression of atherosclerotic lesions and vascular calcification in transgenic rabbits. Chen Y, et al. J Cell Mol Med, 2020 Apr. PMID 32126159, Free PMC Article
  2. MicroRNA-133b regulates the growth and migration of vascular smooth muscle cells by targeting matrix metallopeptidase 9. Liu H, et al. Pathol Res Pract, 2019 May. PMID 30926224
  3. Early stage minimally invasive procedures reduce perihematomal MMP-9 and blood-brain barrier disruption in a rabbit model of intracerebral hemorrhage. Wu G, et al. Neurol Res, 2013 Jul. PMID 23561043
  4. [Relationship between expression of MMP-9 and presyrinx state of experimental syringomyelia of rabbits]. Shen QF, et al. Zhonghua Yi Xue Za Zhi, 2010 Sep 21. PMID 21092471
  5. Cytokines and signaling pathways regulating matrix metalloproteinase-9 (MMP-9) expression in corneal epithelial cells. Gordon GM, et al. J Cell Physiol, 2009 Nov. PMID 19626678, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Macrophage-derived MMP-9 enhances the progression of atherosclerotic lesions and vascular calcification in transgenic rabbits.
    Title: Macrophage-derived MMP-9 enhances the progression of atherosclerotic lesions and vascular calcification in transgenic rabbits.
  2. Modulation of MMP-2 and MMP-9 is critical for extracellular matrix balance of intra-articular ligaments.
    Title: Modulation of MMP-2 and MMP-9 through connected pathways and growth factors is critical for extracellular matrix balance of intra-articular ligaments.
  3. these findings highlight an important role for miR-133b/MMP-9 axis in atherosclerosis.
    Title: MicroRNA-133b regulates the growth and migration of vascular smooth muscle cells by targeting matrix metallopeptidase 9.
  4. The present study demonstrated the ability of 30 and 100 ng/ml TIMP3 to attenuate migration and proliferation, and to inhibit the activity of MMP2, MMP9 and TNFalpha secretion of NA SMCs. In conclusion, TIMP3 may be considered a potential therapeutic drug for use in a novel drugeluting stent, to attenuate the progressive dilation of the aortic NA.
    Title: TIMP‑3 suppresses the proliferation and migration of SMCs from the aortic neck of atherosclerotic AAA in rabbits, via decreased MMP‑2 and MMP‑9 activity, and reduced TNF‑α expression.
  5. Expression of MMP-9 increased after cerebral aneurysm induction, peaking at week 3, leading to reduced smooth muscle cell number, damaged endothelial cells, and damage to the aneurysm wall elastic layer.
    Title: Expression of NF-κB, MCP-1 and MMP-9 in a Cerebral Aneurysm Rabbit Model.
  6. Inflammatory factors such as TNF-alpha can stimulate MMP-2/9 activity in corneal epithelium cells. This may be a potential manipulating mechanism of MMP expression in the pathogenesis of corneal diseases
    Title: Activity of matrix metalloproteinases 2 and 9 in cultured rabbit corneal epithelium cells stimulated by tumor necrosis factor alpha.
  7. Therefore, it was reasonable to speculate that the increased expression of VEGF and MMP-9 in residual hepatic tumor cells and tumor angiogenesis post-embolization would be responsible for the increased metastatic potentiality and invasiveness.
    Title: Over-expression of VEGF and MMP-9 in residual tumor cells of hepatocellular carcinoma after embolization with lipidol.
  8. Performing minimally invasive surgical procedures in the early stages of intracerebral hemorrhage significantly decreases MMP-9.
    Title: Early stage minimally invasive procedures reduce perihematomal MMP-9 and blood-brain barrier disruption in a rabbit model of intracerebral hemorrhage.
  9. Increased expression of MMP-9 in spinal cord follows cervical spondylotic myelopathy.
    Title: Immunohistochemical profile of NF-κB/p50, NF-κB/p65, MMP-9, MMP-2, and u-PA in experimental cervical spondylotic myelopathy.
  10. Hemoperfusion could obviously reduce oxidative stress and the expression levels of MMP-2, MMP-9 and TIMP-1 in rabbits with acute paraquat poisoning.
    Title: [Effects of hemoperfusion on oxidative stress, matrix metalloproteinases and their inhibitors in acute paraquat poisoning rabbits].
Submit: New GeneRIF Correction See all GeneRIFs (15)

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in collagen catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
matrix metalloproteinase-9
Names
92 kDa gelatinase
92 kDa type IV collagenase
GELB
MMP-9
Preproform of 92-kDa type IV collagenase (MMP-9): N-terminal
gelatinase B
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
NP_001075672.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082203.1 → NP_001075672.1  matrix metalloproteinase-9 precursor

    See identical proteins and their annotated locations for NP_001075672.1

    Status: PROVISIONAL

    Source sequence(s)
    D26514
    UniProtKB/Swiss-Prot
    P41246
    UniProtKB/TrEMBL
    G1U6L9
    Conserved Domains (6) summary
    smart00059
    Location:223 → 271
    FN2; Fibronectin type 2 domain
    cd00094
    Location:514 → 704
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:115 → 444
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00040
    Location:347 → 388
    fn2; Fibronectin type II domain
    pfam00413
    Location:115 → 444
    Peptidase_M10; Matrixin
    pfam04886
    Location:472 → 507
    PT; PT repeat

RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UM_NZW_1.0 Primary Assembly

Genomic

  1. NC_067377.1 Reference UM_NZW_1.0 Primary Assembly

    Range
    2788510..2795456 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P41246.1 GenPept UniProtKB/Swiss-Prot:P41246

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.