thoc6 THO complex 6 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: thoc6provided by ZNC
Official Full Name: THO complex 6provided by ZNC
Primary source: ZFIN:ZDB-GENE-041010-198
See related: Ensembl:ENSDARG00000037966 AllianceGenome:ZFIN:ZDB-GENE-041010-198
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:101618
Summary: Predicted to enable RNA binding activity. Predicted to act upstream of or within RNA processing; apoptotic process; and mRNA transport. Predicted to be located in nuclear speck. Orthologous to human THOC6 (THO complex 6). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (32651720..32658430)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (32520006..32526716)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

fe05g09.x1 (e-PCR)
- UniSTS:195998

fb96g04 (e-PCR)
- UniSTS:189118

fb96g10 (e-PCR)
- UniSTS:189119

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA splicing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of THO complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription export complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: THO complex subunit 6 homolog

Names: THO complex 6 homolog; WD repeat-containing protein 58

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001006095.1 → NP_001006095.1 THO complex subunit 6 homolog

See identical proteins and their annotated locations for NP_001006095.1

Status: PROVISIONAL

Source sequence(s)

BC083222

UniProtKB/Swiss-Prot

Q5XJS5

Related

ENSDARP00000055337.4, ENSDART00000055338.6

Conserved Domains (3) summary

COG2319
Location:10 → 240

WD40; WD40 repeat [General function prediction only]

sd00039
Location:16 → 58

7WD40; WD40 repeat [structural motif]

cl02567
Location:11 → 215

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...