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    CDH2 cadherin 2, type 1, N-cadherin (neuronal) [ Homo sapiens ]

    Gene ID: 1000, updated on 19-May-2012
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    Summary

    Official Symbol
    CDH2provided by HGNC
    Official Full Name
    cadherin 2, type 1, N-cadherin (neuronal)provided by HGNC
    Primary source
    HGNC:1759
    See related
    Ensembl:ENSG00000170558; HPRD:00226; MIM:114020; Vega:OTTHUMG00000059940
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CDHN; NCAD; CD325; CDw325
    Summary
    This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    18q11.2
    Sequence :
    Chromosome: 18; NC_000018.9 (25530930..25757445, complement)
    See CDH2 in Epigenomics, MapViewer

    Chromosome 18 - NC_000018.9Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 22 pseudogene 1 Neighboring gene proliferation-associated 2G4 pseudogene 3 Neighboring gene ariadne homolog 2 pseudogene 1 Neighboring gene microRNA 302f

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Twist modulates human trophoblastic cell invasion via regulation of N-cadherin. Ng YH, et al. Endocrinology, 2012 Feb. PMID 22166980.
    2. Cadherin engagement protects human β-cells from apoptosis. Parnaud G, et al. Endocrinology, 2011 Dec. PMID 21990317.
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    4. Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling. Berndt JD, et al. J Cell Biol, 2011 Sep 5. PMID 21875946.
    5. Premature osteoblast clustering by enamel matrix proteins induces osteoblast differentiation through up-regulation of connexin 43 and N-cadherin. Miron RJ, et al. PLoS One, 2011. PMID 21858092.

    See all (163) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. N-cad expression is decreased in hepatocellular carcinoma, and the downregulation of N-cad is associated with the metastatic potential and poorer surgical prognosis.
      Title: Reduced N-cadherin expression is associated with metastatic potential and poor surgical outcomes of hepatocellular carcinoma.
    2. Twist is an upstream regulator of N-cadherin-mediated invasion of human trophoblastic cells.
      Title: Twist modulates human trophoblastic cell invasion via regulation of N-cadherin.
    3. expression of calsenilin leads to a disruption of presenilin 1/gamma-secretase-mediated epsilon-cleavage of N-cadherin, which results in the significant accumulation of N-cadherin C-terminal fragment 1
      Title: Calsenilin regulates presenilin 1/γ-secretase-mediated N-cadherin ε-cleavage and β-catenin signaling.
    4. myeloma cells frequently display aberrant expression of N-cadherin and that N-cadherin mediates the interaction of myeloma cells with the bone marrow microenvironment, in particular the osteoblasts.
      Title: N-cadherin-mediated interaction with multiple myeloma cells inhibits osteoblast differentiation.
    5. E- and N-cadherins are expressed at the surface of human beta-cells and that these adhesion molecules are involved in the maintenance of beta-cell viability
      Title: Cadherin engagement protects human β-cells from apoptosis.
    6. Data show that EMD significantly increased the expression of connexin 43 and N-cadherin at early time points ranging from 2 to 5 days.
      Title: Premature osteoblast clustering by enamel matrix proteins induces osteoblast differentiation through up-regulation of connexin 43 and N-cadherin.
    7. The N-cadherin in prostate cancer cell mediates cell-cell adhesion and regulates MCP-1 expression via the PI3K/Akt signaling pathway.
      Title: N-cadherin mediates angiogenesis by regulating monocyte chemoattractant protein-1 expression via PI3K/Akt signaling in prostate cancer cells.
    8. N-cadherin is a receptor for adhesion and endocytosis of Aspergillus fumigatus by HUVEC.
      Title: [N-cadherin as a receptor for adhesion and endocytosis of Aspergillus fumigatus by human umbilical vein endothelial cells].
    9. expression of ZO-1 and N-cadherin may reflect the mechanisms leading to rosette formation in neuroendocrine tumors
      Title: Specific expression of ZO-1 and N-cadherin in rosette structures of various tumors: possible recapitulation of neural tube formation in embryogenesis and utility as a potentially novel immunohistochemical marker of rosette formation in pulmonary neuroendocrine tumors.
    10. N-cadherin plays an important role in maintaining the self-renewal and drug resistance properties of leukemic stem cells.
      Title: [Role of N-cadherin in maintaining leukemic stem cell properties].
    Submit: New GeneRIF Correction See all (109)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P19022 RICS ARHGAP32    HPRD  PubMed  
    P19022 O00192 ARVCF    HPRD  PubMed  
    P19022 Brother of CDON BOC    HPRD  PubMed  
    P19022 P55287 CDH11    HPRD  PubMed  
    P19022 P55283 CDH4    HPRD  PubMed  
    P19022 Q4KMG0 CDON    HPRD  PubMed  
    P19022 Q92793 CREBBP    HPRD  PubMed  
    P19022 P35221 CTNNA1    HPRD  PubMed  
    P19022 P35222 CTNNB1    HPRD  PubMed  
    P19022 Q9UQB3 CTNND2    HPRD  PubMed  
    P19022 P22455 FGFR4    HPRD  PubMed  
    P19022 Q03113 GNA12    HPRD  PubMed  
    P19022 Q14344 GNA13    HPRD  PubMed  
    P19022 Q13002 GRIK2    HPRD  PubMed  
    P19022 Q05586 GRIN1    HPRD  PubMed  
    P19022 O15399 GRIN2D    HPRD  PubMed  
    P19022 P14923 JUP    HPRD  PubMed  
    P19022 Q96NW7 LRRC7    HPRD  PubMed  
    P19022 P27986 PIK3R1    HPRD  PubMed  
    P19022 P18031 PTPN1    HPRD  PubMed  
    BioGRID:107435 BioGRID:106573 ACTA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107435 BioGRID:124859 BOC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107435 BioGRID:107444 CDH11    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107435 BioGRID:107437 CDH4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107435 BioGRID:119165 CDON    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107435 BioGRID:107876 CTNNA1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107435 BioGRID:107880 CTNNB1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107435 BioGRID:107881 CTNND1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107435 BioGRID:109030 GNA12    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107435 BioGRID:115914 GNA13    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107435 BioGRID:109931 JUP    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107435 BioGRID:121610 LRRC7    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107435 BioGRID:114074 PKP4    BioGRID  PubMed Two-hybrid 
    BioGRID:107435 BioGRID:119719 RAB8B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107435 BioGRID:112171 RYK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107435 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Adherens junctions interactions, organism-specific biosystem (from REACTOME)
      Adherens junctions interactions, organism-specific biosystemThe adherens junctions (AJ) are multiprotein complexes that promote homotypic cell adhesion in nearly all types of tissue by linking membrane and cytoskeletal components at discrete contact regions (...
    • Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem (from KEGG)
      Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
    • Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem (from KEGG)
      Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
    • CDO in myogenesis, organism-specific biosystem (from REACTOME)
      CDO in myogenesis, organism-specific biosystemCDO/Cdon (cell-adhesion-molecule-related/downregulated by oncogenes) is a type I transmembrane multifunctional co-receptor consisting of five immunoglobulin and three fibronectin type III (FNIII) rep...
    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell junction organization, organism-specific biosystem (from REACTOME)
      Cell junction organization, organism-specific biosystem
      Cell junction organization
    • Cell-Cell communication, organism-specific biosystem (from REACTOME)
      Cell-Cell communication, organism-specific biosystemCell-to-Cell communication is crucial for multicellular organisms because it allows organisms to coordinate the activity of their cells. Some cell-to-cell communication requires direct cell-cell cont...
    • Cell-cell junction organization, organism-specific biosystem (from REACTOME)
      Cell-cell junction organization, organism-specific biosystemEpithelial cell-cell contacts consist of three major adhesion systems: adherens junctions (AJs), tight junctions (TJs), and desmosomes. These adhesion systems differ in their function and compositio...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • FGF signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      FGF signaling pathway, organism-specific biosystem
      FGF signaling pathway
    • Myogenesis, organism-specific biosystem (from REACTOME)
      Myogenesis, organism-specific biosystemMyogenesis, the formation of muscle tissue, is a complex process involving steps of cell proliferation mediated by growth factor signaling, cell differentiation, reorganization of cells to form myotu...
    • N-cadherin signaling events, organism-specific biosystem (from Pathway Interaction Database)
      N-cadherin signaling events, organism-specific biosystem
      N-cadherin signaling events
    • Signaling events mediated by PTP1B, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by PTP1B, organism-specific biosystem
      Signaling events mediated by PTP1B

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RPTP-like protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    alpha-catenin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    beta-catenin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    gamma-catenin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein phosphatase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    adherens junction organization TAS
    Traceable Author Statement
    more info
    		  
    blood vessel morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    calcium-dependent cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell adhesion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cell junction assembly TAS
    Traceable Author Statement
    more info
    		  
    cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell-cell junction organization TAS
    Traceable Author Statement
    more info
    		  
    heterophilic cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    homophilic cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    muscle cell differentiation TAS
    Traceable Author Statement
    more info
    		  
    negative regulation of canonical Wnt receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of muscle cell differentiation TAS
    Traceable Author Statement
    more info
    		  
    regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of axonogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of myelination IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of protein localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    striated muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    synapse assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    catenin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cell-cell adherens junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    fascia adherens IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    lamellipodium IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane fraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    synapse part IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    cadherin-2
    Names
    cadherin-2
    N-cadherin 1
    neural cadherin
    neural-cadherin
    cadherin 2, N-cadherin (neuronal)
    calcium-dependent adhesion protein, neuronal
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011959.1 RefSeqGene

      Range
      5001..231516
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001792.3 → NP_001783.2  cadherin-2 preproprotein

      Status: REVIEWED

      Source sequence(s)
      AA661623, AI752179, BC036470, CN263272, DA225616, M34064, S42303
      Consensus CDS
      CCDS11891.1
      UniProtKB/Swiss-Prot
      P19022
      Related
      ENSP00000269141, OTTHUMP00000066304, ENST00000269141, OTTHUMT00000133246
      Conserved Domains (4) summary
      pfam01049
      Location:753 – 904
      Blast Score: 351
      Cadherin_C; Cadherin cytoplasmic region
      cl07391
      Location:31 – 123
      Blast Score: 354
      Cadherin_pro; Cadherin prodomain like
      cd11304
      Location:273 – 378
      Blast Score: 272
      Cadherin_repeat; Cadherin tandem repeat domain.
      cl15786
      Location:163 – 245
      Blast Score: 158
      CA_like; Cadherin repeat-like domain.

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000018.9 Reference GRCh37.p5 Primary Assembly

      Range
      25530930..25757445, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000150.1 Alternate HuRef

      Range
      22383072..22579896, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC006249.1 (153926..194231) None
    genomic AC015933.9 (108856..249020) None
    genomic AC110015.5 (122603..168388) None
    genomic CH471088.1 EAX01239.1
      EAX01240.1
      EAX01241.1
    genomic EF444966.1 ACA05964.1
    genomic JA438438.1 CCD32808.1
    genomic JA611023.1 CCE25962.1
    genomic Z27420.1 CAA81799.1
    mRNA AA661623.1 None
    mRNA AI675151.1 None
    mRNA AI752179.1 None
    mRNA AI752180.1 None
    mRNA AK302831.1 BAH13814.1
    mRNA AW016710.1 None
    mRNA BC021695.1 None
    mRNA BC036470.1 AAH36470.1
    mRNA BG197310.1 None
    mRNA BX648579.1 None
    mRNA CN263272.1 None
    mRNA DA225616.1 None
    mRNA M34064.1 AAA03236.1
    mRNA S42303.1 AAB22854.1
    mRNA X54315.1 CAA38213.1
    mRNA X57548.1 CAA40773.1
    other-genetic EU832318.1 ACE87575.1
    other-genetic EU832403.1 ACE86888.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P19022.4 GenPept UniProtKB/Swiss-Prot:P19022
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
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