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A1BG alpha-1-B glycoprotein [ Homo sapiens (human) ]

Gene ID: 1, updated on 8-May-2016
Official Symbol
A1BGprovided by HGNC
Official Full Name
alpha-1-B glycoproteinprovided by HGNC
Primary source
HGNC:HGNC:5
See related
Ensembl:ENSG00000121410 HPRD:00726; MIM:138670; Vega:OTTHUMG00000183507
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
A1B; ABG; GAB; HYST2477
Summary
The protein encoded by this gene is a plasma glycoprotein of unknown function. The protein shows sequence similarity to the variable regions of some immunoglobulin supergene family member proteins. [provided by RefSeq, Jul 2008]
Orthologs
Location:
19q13.4
Exon count:
8
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 19 NC_000019.10 (58346806..58353499, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58858172..58864865, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372480 Neighboring gene zinc finger protein 470 pseudogene Neighboring gene zinc finger and SCAN domain containing 22 Neighboring gene microRNA 6806 Neighboring gene A1BG antisense RNA 1 Neighboring gene zinc finger protein 446 pseudogene Neighboring gene zinc finger protein 497 Neighboring gene uncharacterized LOC105372483

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
    Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
  • Platelet degranulation, organism-specific biosystem (from REACTOME)
    Platelet degranulation, organism-specific biosystemPlatelets function as exocytotic cells, secreting a plethora of effector molecules at sites of vascular injury. Platelets contain a number of distinguishable storage granules including alpha granules...
  • Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME)
    Response to elevated platelet cytosolic Ca2+, organism-specific biosystemActivation of phospholipase C enzymes results in the generation of second messengers of the phosphatidylinositol pathway. The events resulting from this pathway are a rise in intracellular calcium an...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Potential readthrough

Included gene: ZNF497

Homology

Clone Names

  • DKFZp686F0970

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
platelet degranulation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
blood microparticle IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
platelet alpha granule lumen TAS
Traceable Author Statement
more info
 
Preferred Names
alpha-1B-glycoprotein
Names
HEL-S-163pA
epididymis secretory sperm binding protein Li 163pA

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130786.3NP_570602.2  alpha-1B-glycoprotein precursor

    See identical proteins and their annotated locations for NP_570602.2

    Status: REVIEWED

    Source sequence(s)
    AB073611, AK056201, BX325198
    Consensus CDS
    CCDS12976.1
    UniProtKB/Swiss-Prot
    P04217
    UniProtKB/TrEMBL
    V9HWD8
    Related
    ENSP00000263100, OTTHUMP00000271867, ENST00000263100, OTTHUMT00000466930
    Conserved Domains (4) summary
    cd05751
    Location:401493
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
    smart00408
    Location:224282
    IGc2; Immunoglobulin C-2 Type
    pfam13895
    Location:218300
    Ig_2; Immunoglobulin domain
    cl11960
    Location:28110
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p2 Primary Assembly

    Range
    58346806..58353499 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 Alternate CHM1_1.1

    Range
    58852105..58858795 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)