A1BG alpha-1-B glycoprotein [Homo sapiens] - Gene

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Summary

Official Symbol: A1BGprovided by HGNC
Official Full Name: alpha-1-B glycoproteinprovided by HGNC
Primary source: HGNC:5
See related: Ensembl:ENSG00000121410; HPRD:00726; MIM:138670
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: A1B; ABG; GAB; HYST2477; DKFZp686F0970
Summary: The protein encoded by this gene is a plasma glycoprotein of unknown function. The protein shows sequence similarity to the variable regions of some immunoglobulin supergene family member proteins. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 19q13.4

Sequence :: Chromosome: 19; NC_000019.9 (58858172..58864865, complement)

See A1BG in Epigenomics, MapViewer

Chromosome 19 - NC_000019.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

an 11-fold upregulated 13.8 kDa fragment of alpha 1-B glycoprotein (A1BG) as a biomarker for steroid-resistant nephrotic syndrome
Title: Discovery and initial validation of α 1-B glycoprotein fragmentation as a differential urinary biomarker in pediatric steroid-resistant nephrotic syndrome.
Complex binding of CRISP proteins by A1BG and other proteins may interfere with the detection and function of these proteins.
Title: Human CRISP-3 binds serum alpha(1)B-glycoprotein across species.
MMP-9, DJ-1 and A1BG proteins are overexpressed in pancreatic juice from pancreatic ductal adenocarcinoma
Title: Proteomic analysis identifies MMP-9, DJ-1 and A1BG as overexpressed proteins in pancreatic juice from pancreatic ductal adenocarcinoma patients.
A1BG-cysteine-rich secretory protein 3 complex displays a similar function in protecting the circulation from a potentially harmful effect of free CRISP-3
Title: Cysteine-rich secretory protein 3 is a ligand of alpha1B-glycoprotein in human plasma.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
P04217	P54108	CRISP3	HPRD	PubMed
BioGRID:106523	BioGRID:106807	ANXA7	BioGRID	PubMed	Two-hybrid
BioGRID:106523	BioGRID:107460	CDKN1A	BioGRID	PubMed	Two-hybrid
BioGRID:106523	BioGRID:115605	CRISP3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106523	BioGRID:109143	GRB7	BioGRID	PubMed	Two-hybrid
BioGRID:106523	BioGRID:112490	SMN1	BioGRID	PubMed	Two-hybrid
BioGRID:106523	BioGRID:112506	SNCA	BioGRID	PubMed	Two-hybrid
BioGRID:106523	BioGRID:112938	TK1	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
extracellular region	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: alpha-1B-glycoprotein

Names: alpha-1B-glycoprotein

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130786.3 → NP_570602.2 alpha-1B-glycoprotein precursor

Status: REVIEWED

Source sequence(s)

AB073611, AK056201, BX325198

Consensus CDS

CCDS12976.1

UniProtKB/Swiss-Prot

P04217

Related

ENSP00000263100, ENST00000263100

Conserved Domains (2) summary

cd05751
Location:401 – 493
Blast Score: 330

Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins

cl11960
Location:28 – 110
Blast Score: 105

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000019.9 Reference GRCh37.p5 Primary Assembly

Range

58858172..58864865, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000151.1 Alternate HuRef

Range

55167316..55174020, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC010642.5 (41118..43580)	None
genomic	AC012313.7 (3382..11695)	None
genomic	CH471135.1	EAW72575.1
mRNA	AA484435.1	None
mRNA	AB073611.1	BAD38648.1
mRNA	AF414429.1	AAL07469.1
mRNA	AI022193.1	None
mRNA	AK055885.1	BAG51591.1
mRNA	AK056201.1	None
mRNA	AK289417.1	BAF82106.1
mRNA	BC035719.1	AAH35719.1
mRNA	BX325198.2	None
mRNA	BX537419.1	CAD97661.1
mRNA	T80683.1	None
mRNA	W25099.1	None