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    CDC42 cell division cycle 42 (GTP binding protein, 25kDa) [ Homo sapiens ]

    Gene ID: 998, updated on 23-May-2012
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    Summary

    Official Symbol
    CDC42provided by HGNC
    Official Full Name
    cell division cycle 42 (GTP binding protein, 25kDa)provided by HGNC
    Primary source
    HGNC:1736
    Locus tag
    RP1-224A6.5
    See related
    Ensembl:ENSG00000070831; HPRD:00309; MIM:116952; Vega:OTTHUMG00000002753
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    G25K; CDC42Hs
    Summary
    The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    1p36.1
    Sequence :
    Chromosome: 1; NC_000001.10 (22379120..22419436)
    See CDC42 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene chymotrypsin-like elastase family, member 3A Neighboring gene long intergenic non-protein coding RNA 339 Neighboring gene wingless-type MMTV integration site family, member 4 Neighboring gene microRNA 4418

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Identification of F-actin as the dynamic hub in a microbial-induced GTPase polarity circuit. Orchard RC, et al. Cell, 2012 Feb 17. PMID 22341450.
    2. Transport of influenza virus neuraminidase (NA) to host cell surface is regulated by ARHGAP21 and Cdc42 proteins. Wang S, et al. J Biol Chem, 2012 Mar 23. PMID 22318733.
    3. A targeted siRNA screen identifies regulators of Cdc42 activity at the natural killer cell immunological synapse. Carlin LM, et al. Sci Signal, 2011 Nov 29. PMID 22126964.
    4. Burkholderia cenocepacia disrupts host cell actin cytoskeleton by inactivating Rac and Cdc42. Flannagan RS, et al. Cell Microbiol, 2012 Feb. PMID 22023324.
    5. PTEN regulates colorectal epithelial apoptosis through Cdc42 signalling. Deevi R, et al. Br J Cancer, 2011 Oct 25. PMID 21952626.

    See all (351) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. silencing Cdc42 reduced influenza A virus replication, whereas silencing ARHGAP21 increased the virus replication.
      Title: Transport of influenza virus neuraminidase (NA) to host cell surface is regulated by ARHGAP21 and Cdc42 proteins.
    2. Burkholderia cenocepacia perturbs actin architecture by inactivating Rho family GTPases, particularly Rac1 and Cdc42.
      Title: Burkholderia cenocepacia disrupts host cell actin cytoskeleton by inactivating Rac and Cdc42.
    3. Aberrant expression of Annexin A2 and Cdc42 play a role in carcinogenesis, differentiation and metastasis of esophageal squamous cell carcinomas.
      Title: Clinicopathological pattern and Annexin A2 and Cdc42 status in patients presenting with differentiation and lymphnode metastasis of esophageal squamous cell carcinomas.
    4. Cdc42 enhances the resistance of colon cancer cells to several antitumor drugs.
      Title: [The effect of small GTPase Cdc42 on the multidrug resistance of oxaliplatin-resistant colon cancer cell lines].
    5. Using synthetic derivatives of the enteropathogenic Escherichia coli guanine-nucleotide exchange factor (GEF) Map, authors discover that Cdc42 GTPase signal transduction is controlled by the interaction between Map and F-actin.
      Title: Identification of F-actin as the dynamic hub in a microbial-induced GTPase polarity circuit.
    6. The guanine nucleotide exchange factors RhoGEF6 and RhoGEF7 were necessary for Cdc42 activation within the NK cell immunological synapse.
      Title: A targeted siRNA screen identifies regulators of Cdc42 activity at the natural killer cell immunological synapse.
    7. endogenous Cdc42 could exert a negative regulatory influence on intrinsic migration/invasion and some potentially relevant changes in phosphorylation of PKCdelta, Erk1/2, and PKA of some aggressive breast cancer cells
      Title: Cdc42 negatively regulates intrinsic migration of highly aggressive breast cancer cells.
    8. Multiple factors confer specific Cdc42 and Rac protein activation by dedicator of cytokinesis (DOCK) nucleotide exchange factors.
      Title: Multiple factors confer specific Cdc42 and Rac protein activation by dedicator of cytokinesis (DOCK) nucleotide exchange factors.
    9. HIV-1 activates Cdc42 and induces membrane extensions in immature dendritic cells to facilitate cell-to-cell virus propagation.
      Title: HIV-1 activates Cdc42 and induces membrane extensions in immature dendritic cells to facilitate cell-to-cell virus propagation.
    10. Phosphatase and tensin homologue deleted on chromosome 10 may influence apoptosis in colorectal epithelium through Cdc42 signalling, thus providing a regulatory framework for both polarised growth and programmed cell death.
      Title: PTEN regulates colorectal epithelial apoptosis through Cdc42 signalling.
    Submit: New GeneRIF Correction See all (175)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Nef inhibits the concomitant activation of the actin organizer N-Wasp by interfering with the translocation of N-Wasp to the cell periphery and blocks morphological changes induced by the known N-Wasp regulators Rac1 and Cdc42 PubMed
    nef The activation of Nef-associated kinase (NAK; also known as p21-activated kinase 1 or PAK1) by HIV-1 Nef is via the small GTPases Cdc42 and Rac1, suggesting an interaction between Nef and these GTPases PubMed
    nef HIV-1 Nef treatment upregulates active CDC42 levels in dendritic cells PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    AAA52592.1 NP_000368.1 WAS    BIND  PubMed Cdc42 interacts with WASP. 
    NP_001782.1 NP_006770.1 CDC42EP2    BIND  PubMed Activated Cdc42 interacts with Borg1. This interaction was modeled on a demonstrated interaction between Cdc42 from an unspecified species and Borg1 from human. 
    NP_001782.1 NP_006440.2 CDC42EP3    BIND  PubMed Activated Cdc42 interacts with Borg2. This interaction was modeled on a demonstrated interaction between Cdc42 from an unspecified species and Borg2 from human. 
    NP_001782.1 NP_003015.2 ITSN1    BIND  PubMed Cdc42 specifically interacts with Dbl-homology and pleckstrin-homology domains of the nucleotide exchange factor ITSN1. 
    NP_001782.1 NP_079255.2 MCF2L    BIND  PubMed Cdc42 specifically interacts with Dbl-homology and pleckstrin-homology domains of the nucleotide exchange factor Dbs. This interaction is modelled on a demonstrated interaction between mouse Dbs and human Cdc42. 
    NP_001782.1 NP_000368.1 WAS    BIND  PubMed CDC42 interacts with WASP. This interaction was modeled on a demonstrated interaction between CDC42 and WASP from an unspecified species. 
    NP_001782.1 AAC02071.1     BIND  PubMed Cdc42 interacts with the bacterial enteropathogenic Salmonella typhimurium toxin SopE 
    NP_001782.1     BIND  PubMed Cdc42 interacts with GTP. This interaction is modelled on a demonstrated interaction between human Cdc42 and GTP analogue GMPPNP. 
    NP_001782.1     BIND  PubMed Cdc42 interacts with magnesium. 
    NP_426359.1 CAC39270.1     BIND  PubMed YopT cleaves Cdc42 amino-terminal to prenylated Cys188. This interaction was modeled on a demonstrated interaction between Yersinia pseudotuberculosis YopT and Cdc42 from an unspecified species. 
    P60953 P61158 ACTR3    HPRD  PubMed  
    P60953 P07355 ANXA2    HPRD  PubMed  
    P60953 Q07960 ARHGAP1    HPRD  PubMed  
    P60953 CdGAP ARHGAP31    HPRD  PubMed  
    P60953 P52565 ARHGDIA    HPRD  PubMed  
    P60953 P52566 ARHGDIB    HPRD  PubMed  
    P60953 Q99819 ARHGDIG    HPRD  PubMed  
    P60953 RAC/CDC42 exchange factor ARHGEF25    HPRD  PubMed  
    P60953 Q15052 ARHGEF6    HPRD  PubMed  
    P60953 Q14155 ARHGEF7    HPRD  PubMed  
    P60953 Q9UQB8 BAIAP2    HPRD  PubMed  
    P60953 Q12982 BNIP2    HPRD  PubMed  
    P60953 Q9UKR5 C14orf1    HPRD  PubMed  
    P60953 P42574 CASP3    HPRD  PubMed  
    P60953 P55210 CASP7    HPRD  PubMed  
    P60953 Q6DT37 CDC42BPG    HPRD  PubMed  
    P60953 Q00587 CDC42EP1    HPRD  PubMed  
    P60953 O14613 CDC42EP2    HPRD  PubMed  
    P60953 Q9UKI2 CDC42EP3    HPRD  PubMed  
    P60953 Q6NZY7 CDC42EP5    HPRD  PubMed  
    P60953 CDC42 small effector 1 CDC42SE1    HPRD  PubMed  
    P60953 Q6UVK1 CSPG4    HPRD  PubMed  
    P60953 DEF6 DEF6    HPRD  PubMed  
    P60953 Q96N67 DOCK7    HPRD  PubMed  
    P60953 Q8NF50 DOCK8    HPRD  PubMed  
    P60953 Q9BZ29 DOCK9    HPRD  PubMed  
    P60953 P26641 EEF1G    HPRD  PubMed  
    P60953 P19525 EIF2AK2    HPRD  PubMed  
    P60953 Q9UJM3 ERRFI1    HPRD  PubMed  
    P60953 P98174 FGD1    HPRD  PubMed  
    P60953 P21333 FLNA    HPRD  PubMed  
    P60953 Q96RU3 FNBP1    HPRD  PubMed  
    P60953 P31150 GDI1    HPRD  PubMed  
    P60953 P46940 IQGAP1    HPRD  PubMed  
    P60953 Q13576 IQGAP2    HPRD  PubMed  
    P60953 Q15811 ITSN1    HPRD  PubMed  
    P60953 Q92993 KAT5    HPRD  PubMed  
    P60953 Q86UP2 KTN1    HPRD  PubMed  
    P60953 P06239 LCK    HPRD  PubMed  
    P60953 Q5T3J3 LRIF1    HPRD  PubMed  
    P60953 Q02779 MAP3K10    HPRD  PubMed  
    P60953 Q16584 MAP3K11    HPRD  PubMed  
    P60953 Q9Y6R4 MAP3K4    HPRD  PubMed  
    P60953 Q96L34 MARK4    HPRD  PubMed  
    P60953 O15068 MCF2L    HPRD  PubMed  
    P60953 P50579 METAP2    HPRD  PubMed  
    P60953 Myosin 9A MYO9A    HPRD  PubMed  
    P60953 P19878 NCF2    HPRD  PubMed  
    P60953 Q01968 OCRL    HPRD  PubMed  
    P60953 O60890 OPHN1    HPRD  PubMed  
    P60953 Q13153 PAK1    HPRD  PubMed  
    P60953 Q13177 PAK2    HPRD  PubMed  
    P60953 O96013 PAK4    HPRD  PubMed  
    P60953 Q9NQU5 PAK6    HPRD  PubMed  
    P60953 Q9P286 PAK7    HPRD  PubMed  
    P60953 Q8TEW0 PARD3    HPRD  PubMed  
    P60953 Q9NPB6 PARD6A    HPRD  PubMed  
    P60953 Q9BYG5 PARD6B    HPRD  PubMed  
    P60953 Q9BYG4 PARD6G    HPRD  PubMed  
    P60953 O43924 PDE6D    HPRD  PubMed  
    P60953 P53609 PGGT1B    HPRD  PubMed  
    P60953 P27986 PIK3R1    HPRD  PubMed  
    P60953 Q13393 PLD1    HPRD  PubMed  
    P60953 PLEKHG2 PLEKHG2    HPRD  PubMed  
    P60953 P17252 PRKCA    HPRD  PubMed  
    P60953 P05129 PRKCG    HPRD  PubMed  
    P60953 P41743 PRKCI    HPRD  PubMed  
    P60953 Q05513 PRKCZ    HPRD  PubMed  
    P60953 P15153 RAC2    HPRD  PubMed  
    P60953 Q9H4E5 RHOJ    HPRD  PubMed  
    P60953 P23443 RPS6KB1    HPRD  PubMed  
    P60953 Q7Z6B7 SRGAP1    HPRD  PubMed  
    P60953 O95793 STAU1    HPRD  PubMed  
    P60953 Q8IZP1 TBC1D3F    HPRD  PubMed  
    P60953 Q07912 TNK2    HPRD  PubMed  
    P60953 P04637 TP53    HPRD  PubMed  
    P60953 Q15642 TRIP10    HPRD  PubMed  
    P60953 Q8IWV7 UBR1    HPRD  PubMed  
    P60953 Q13432 UNC119    HPRD  PubMed  
    P60953 P15498 VAV1    HPRD  PubMed  
    P60953 P42768 WAS    HPRD  PubMed  
    P60953 Q92558 WASF1    HPRD  PubMed  
    P60953 Q8IV90 WASF2    HPRD  PubMed  
    BioGRID:107433 BioGRID:106524 A2M    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:106537 ABCA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107433 BioGRID:106700 AHSG    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:106847 APOH    BioGRID  PubMed Two-hybrid 
    NP_004299.1 ARHGAP1    BIND  PubMed Cdc42GAP interacts with Cdc42. This interaction was modelled on a demonstrated interaction between human Cdc42GAP and Cdc42 from an unspecified species. 
    BioGRID:107433 BioGRID:106885 ARHGAP1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:107433 BioGRID:122784 ARHGAP10    BioGRID  PubMed Biochemical Activity 
    BioGRID:107433 BioGRID:120424 ARHGAP17    BioGRID  PubMed Biochemical Activity 
    BioGRID:107433 BioGRID:116720 ARHGAP26    BioGRID  PubMed Biochemical Activity 
    BioGRID:107433 BioGRID:128369 ARHGAP27    BioGRID  PubMed Biochemical Activity 
    BioGRID:107433 BioGRID:114806 ARHGAP29    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:115091 ARHGAP32    BioGRID  PubMed Biochemical Activity; Two-hybrid 
    BioGRID:107433 BioGRID:115241 ARHGAP44    BioGRID  PubMed Biochemical Activity 
    NP_851852.2 ARHGAP8    BIND  PubMed BPGAP1 interacts with Cdc42. 
    BioGRID:107433 BioGRID:106889 ARHGDIA    BioGRID  PubMed Affinity Capture-MS; Co-purification; Two-hybrid 
    BioGRID:107433 BioGRID:106891 ARHGDIG    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107433 BioGRID:115164 ARHGEF11    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:125438 ARHGEF25    BioGRID  PubMed Reconstituted Complex 
    BAA04985.1 ARHGEF6    BIND  PubMed ARHGEF6 (Cool-2) interacts with Cdc42. 
    NP_663788.1 ARHGEF7    BIND  PubMed ARHGEF7 (p85Cool-1) interacts with Cdc42. 
    BioGRID:107433 BioGRID:114393 ARHGEF7    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107433 BioGRID:106901 ARRB1    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:106902 ARRB2    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:207566 Arhgef7    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107433 BioGRID:115721 BAIAP2    BioGRID  PubMed Affinity Capture-Western; Far Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107433 BioGRID:107083 BCR    BioGRID  PubMed Reconstituted Complex 
    NP_004321.1 BNIP2    BIND  PubMed BNIP-2 interacts with an unspecified isoform of Cdc42. This interaction was modeled on a demonstrated interaction between human BNIP-2 and Cdc42 from an unspecified species. 
    NP_004321.1 BNIP2    BIND  PubMed BNIP-2 interacts with an unspecified isoform of Cdc42. 
    NP_004321.1 BNIP2    BIND  PubMed BNIP-2 interacts with Cdc42. This interaction was modelled on a demonstrated interaction between human BNIP-2 and Cdc42 from an unspecified species. 
    BioGRID:107433 BioGRID:107131 BNIP2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid 
    BioGRID:107433 BioGRID:127211 BNIPL    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107433 BioGRID:116332 C14orf1    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:107315 CBL    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107433 BioGRID:122960 CBLL1    BioGRID  PubMed Co-localization; Reconstituted Complex 
    BioGRID:107433 BioGRID:107433 CDC42    BioGRID  PubMed Co-crystal Structure 
    BioGRID:107433 BioGRID:114051 CDC42BPA    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:114947 CDC42BPB    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:120719 CDC42BPG    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107433 BioGRID:116308 CDC42EP1    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:115702 CDC42EP2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:107433 BioGRID:115849 CDC42EP3    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:107433 BioGRID:117115 CDC42EP4    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:127125 CDC42EP5    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:107433 BioGRID:121215 CDC42SE1    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:121306 CDC42SE2    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:107434 CDH1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107433 BioGRID:107460 CDKN1A    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107433 BioGRID:116085 CFHR4    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:112163 CLIP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107433 BioGRID:114078 CNTNAP1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107433 BioGRID:110615 COX1    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:107761 CPN1    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:107834 CSN2    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:107846 CSPG4    BioGRID  PubMed Affinity Capture-Western 
    NP_071330.2 DEF6    BIND  PubMed DEF6 interacts with Cdc42. This interaction was modelled on a demonstrated interaction between human DEF6 and Cdc42 from an unspecified species. 
    BioGRID:107433 BioGRID:119099 DEF6    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107433 BioGRID:108074 DIAPH2    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:123577 DOCK8    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:116930 DOCK9    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107433 BioGRID:207965 Diap3    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:107433 BioGRID:108257 EEF1G    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:119923 ERRFI1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107433 BioGRID:108409 ETFA    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:108536 FGD1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107433 BioGRID:125355 FMNL2    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:120222 FNBP1L    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107433 BioGRID:108932 GDI1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107433 BioGRID:121384 GOPC    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107433 BioGRID:109142 GRB2    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:114438 HERC2    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:114353 IQGAP1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107433 BioGRID:116004 IQGAP2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107433 BioGRID:112351 ITSN1    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex 
    BioGRID:107433 BioGRID:115779 KAT5    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:127672 KIAA2026    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:200955 Kin    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:107433 BioGRID:110147 LGALS1    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:120905 LRIF1    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:110440 MAP3K10    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:107433 BioGRID:110442 MAP3K11    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107433 BioGRID:110380 MAP3K4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107433 BioGRID:121760 MARK4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107433 BioGRID:110336 MCF2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107433 BioGRID:116865 MCF2L    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex 
    BioGRID:107433 BioGRID:114406 MCM3AP    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:115382 MUC12    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:110730 MYO6    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:110733 MYO9A    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:110768 NCF2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107433 BioGRID:207915 Net1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:107433 BioGRID:111029 OPHN1    BioGRID  PubMed Biochemical Activity 
    NP_002567.3 PAK1    BIND  PubMed Cdc42 interacts with Pak1. This interaction was modelled on a demonstrated interaction between Cdc42 from an unspecified species and human Pak1. 
    NP_002567.3 PAK1    BIND  PubMed PAK1 interacts with an unspecified isoform of Cdc42. This interaction was modeled on a demonstrated interaction between PAK1 from an unspecified species and human Cdc42. 
    BioGRID:107433 BioGRID:111095 PAK1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:107433 BioGRID:111098 PAK2    BioGRID  PubMed Protein-peptide; Reconstituted Complex; Two-hybrid 
    BioGRID:107433 BioGRID:111099 PAK3    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:115586 PAK4    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107433 BioGRID:121251 PAK6    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:107433 BioGRID:121402 PAK7    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107433 BioGRID:119157 PARD6A    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107433 BioGRID:124145 PARD6B    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107433 BioGRID:124135 PARD6G    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:107433 BioGRID:111173 PDE6D    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:111353 PLD1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107433 BioGRID:122330 PLEKHG2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107433 BioGRID:202021 Pak3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107433 BioGRID:111817 RAC1    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:111845 RAP1GDS1    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:112066 RPL22    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:114752 RPL23    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:202950 Rock1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:107433 BioGRID:112188 S100A9    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:127448 SH3D19    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:112644 ST13    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:116928 SYNE1    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:123952 TBC1D3F    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107433 BioGRID:112979 TNF    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107433 BioGRID:115485 TNK2    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107433 BioGRID:113010 TP53    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:114733 TRIP10    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:107433 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Two-hybrid 
    BioGRID:107433 BioGRID:128238 UBR1    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:114548 UNC119    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:113252 VAV1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107433 BioGRID:113283 VRK2    BioGRID  PubMed Two-hybrid 
    NP_000368.1 WAS    BIND  PubMed Active GTP-bound CDC42 interacts with WAS (WASP). This interaction was modelled on a demonstrated interaction between chicken CDC42 and human WAS. 
    BioGRID:107433 BioGRID:113293 WAS    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:107433 BioGRID:114466 WASL    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:107433 BioGRID:113517 ZNF175    BioGRID  PubMed Two-hybrid 
    BioGRID:107433 BioGRID:115997 ZNF234    BioGRID  PubMed Two-hybrid 
    NP_057864.1 tax    BIND  PubMed Tax interacts with Cdc42. 
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the CDC42 gene: The CDC42 gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, S.cerevisiae, K.lactis, , S.pombe, , and N.crassa.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Adherens junction, organism-specific biosystem (from KEGG)
      Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Adherens junction, conserved biosystem (from KEGG)
      Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Axon guidance, organism-specific biosystem (from KEGG)
      Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, conserved biosystem (from KEGG)
      Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • Bacterial invasion of epithelial cells, organism-specific biosystem (from KEGG)
      Bacterial invasion of epithelial cells, organism-specific biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
    • Bacterial invasion of epithelial cells, conserved biosystem (from KEGG)
      Bacterial invasion of epithelial cells, conserved biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
    • CD28 co-stimulation, organism-specific biosystem (from REACTOME)
      CD28 co-stimulation, organism-specific biosystemIn naive T cells, CD28 costimulation enhances cell cycle entry, potently stimulates expression of both the mitogenic lymphokine interleukin-2 (IL-2) and its receptor, and stimulates the activation o...
    • CD28 dependent Vav1 pathway, organism-specific biosystem (from REACTOME)
      CD28 dependent Vav1 pathway, organism-specific biosystemCD28 binds to several intracellular proteins including PI3 kinase, Grb-2, Gads and ITK. Grb-2 specifically co-operates with Vav-1 in the up-regulation of NFAT/AP-1 transcription. CD28 costimulation r...
    • CDC42 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      CDC42 signaling events, organism-specific biosystem
      CDC42 signaling events
    • CDO in myogenesis, organism-specific biosystem (from REACTOME)
      CDO in myogenesis, organism-specific biosystemCDO/Cdon (cell-adhesion-molecule-related/downregulated by oncogenes) is a type I transmembrane multifunctional co-receptor consisting of five immunoglobulin and three fibronectin type III (FNIII) rep...
    • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
      Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Chemokine signaling pathway, conserved biosystem (from KEGG)
      Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Costimulation by the CD28 family, organism-specific biosystem (from REACTOME)
      Costimulation by the CD28 family, organism-specific biosystemOptimal activation of T-lymphocytes requires at least two signals. A primary one is delivered by the T-cell receptor (TCR) complex after antigen recognition and additional costimulatory signals are d...
    • DCC mediated attractive signaling, organism-specific biosystem (from REACTOME)
      DCC mediated attractive signaling, organism-specific biosystemThe DCC family includes DCC and neogenin in vertebrates. DCC is required for netrin-induced axon attraction. DCC is a transmembrane protein lacking any identifiable catalytic activity. Protein tyrosi...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • E-cadherin signaling in the nascent adherens junction, organism-specific biosystem (from Pathway Interaction Database)
      E-cadherin signaling in the nascent adherens junction, organism-specific biosystem
      E-cadherin signaling in the nascent adherens junction
    • EGFR downregulation, organism-specific biosystem (from REACTOME)
      EGFR downregulation, organism-specific biosystemRegulation of receptor tyrosine kinase (RTK) activity is implicated in the control of almost all cellular functions. One of the best understood RTKs is epidermal growth factor receptor (EGFR). Growth...
    • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
    • EPHB forward signaling, organism-specific biosystem (from Pathway Interaction Database)
      EPHB forward signaling, organism-specific biosystem
      EPHB forward signaling
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endothelins, organism-specific biosystem (from Pathway Interaction Database)
      Endothelins, organism-specific biosystem
      Endothelins
    • Epithelial cell signaling in Helicobacter pylori infection, organism-specific biosystem (from KEGG)
      Epithelial cell signaling in Helicobacter pylori infection, organism-specific biosystemTwo major virulence factors of H. pylori are the vacuolating cytotoxin (VacA) and the cag type-IV secretion system (T4SS) and its translocated effector protein, cytotoxin-associated antigen A (CagA)....
    • Epithelial cell signaling in Helicobacter pylori infection, conserved biosystem (from KEGG)
      Epithelial cell signaling in Helicobacter pylori infection, conserved biosystemTwo major virulence factors of H. pylori are the vacuolating cytotoxin (VacA) and the cag type-IV secretion system (T4SS) and its translocated effector protein, cytotoxin-associated antigen A (CagA)....
    • ErbB1 downstream signaling, organism-specific biosystem (from Pathway Interaction Database)
      ErbB1 downstream signaling, organism-specific biosystem
      ErbB1 downstream signaling
    • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
      Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
    • Fc gamma R-mediated phagocytosis, organism-specific biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, organism-specific biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
    • Fc gamma R-mediated phagocytosis, conserved biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, conserved biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • G alpha (12/13) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (12/13) signalling events, organism-specific biosystemThe G12/13 family is probably the least well characterized subtype, partly because G12/13 coupling is difficult to determine when compared with the other subtypes which predominantly rely on assay te...
    • G13 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      G13 Signaling Pathway, organism-specific biosystemThe G13 subunit is an alpha unit of heterotrimeric G proteins that regulates cell processes through the use of guanine nucleotide exchange factors. G13 regulates actin cytoskeletal remodeling in cell...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPVI-mediated activation cascade, organism-specific biosystem (from REACTOME)
      GPVI-mediated activation cascade, organism-specific biosystemThe GPVI receptor is a complex of the GPVI protein with Fc epsilon R1 gamma (FcR). The Src family kinases Fyn and Lyn constitutively associate with the GPVI-FcR complex in platelets and initiate plat...
    • GnRH signaling pathway, organism-specific biosystem (from KEGG)
      GnRH signaling pathway, organism-specific biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
    • GnRH signaling pathway, conserved biosystem (from KEGG)
      GnRH signaling pathway, conserved biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Inactivation of Cdc42 and Rac, organism-specific biosystem (from REACTOME)
      Inactivation of Cdc42 and Rac, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Inactivation of Cdc42 and Rac, organism-specific biosystem (from REACTOME)
      Inactivation of Cdc42 and Rac, organism-specific biosystemRho family GTPases including Rac, Rho, and Cdc42 are ideal candidates to regulate aspects of cytoskeletal dynamics downstream of axon guidance receptors. Biochemical and genetic studies have revealed...
    • Integrin-mediated cell adhesion, organism-specific biosystem (from WikiPathways)
      Integrin-mediated cell adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...
    • Internalization of ErbB1, organism-specific biosystem (from Pathway Interaction Database)
      Internalization of ErbB1, organism-specific biosystem
      Internalization of ErbB1
    • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
      Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
      Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Lissencephaly gene (LIS1) in neuronal migration and development, organism-specific biosystem (from Pathway Interaction Database)
      Lissencephaly gene (LIS1) in neuronal migration and development, organism-specific biosystem
      Lissencephaly gene (LIS1) in neuronal migration and development
    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Myogenesis, organism-specific biosystem (from REACTOME)
      Myogenesis, organism-specific biosystemMyogenesis, the formation of muscle tissue, is a complex process involving steps of cell proliferation mediated by growth factor signaling, cell differentiation, reorganization of cells to form myotu...
    • Nectin adhesion pathway, organism-specific biosystem (from Pathway Interaction Database)
      Nectin adhesion pathway, organism-specific biosystem
      Nectin adhesion pathway
    • Netrin-1 signaling, organism-specific biosystem (from REACTOME)
      Netrin-1 signaling, organism-specific biosystemNetrins are secreted proteins that play a crucial role in neuronal migration and in axon guidance during the development of the nervous system. To date, several Netrins have been described in mouse a...
    • Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
      Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem
      Neurotrophic factor-mediated Trk receptor signaling
    • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
      Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
      Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Noncanonical Wnt signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      Noncanonical Wnt signaling pathway, organism-specific biosystem
      Noncanonical Wnt signaling pathway
    • Osteopontin-mediated events, organism-specific biosystem (from Pathway Interaction Database)
      Osteopontin-mediated events, organism-specific biosystem
      Osteopontin-mediated events
    • Pancreatic cancer, organism-specific biosystem (from KEGG)
      Pancreatic cancer, organism-specific biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pancreatic cancer, conserved biosystem (from KEGG)
      Pancreatic cancer, conserved biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pathogenic Escherichia coli infection, organism-specific biosystem (from KEGG)
      Pathogenic Escherichia coli infection, organism-specific biosystemEnteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction o...
    • Pathogenic Escherichia coli infection, conserved biosystem (from KEGG)
      Pathogenic Escherichia coli infection, conserved biosystemEnteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction o...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
      Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
    • Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
      Regulation of Actin Cytoskeleton, organism-specific biosystem
      Regulation of Actin Cytoskeleton
    • Regulation of CDC42 activity, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of CDC42 activity, organism-specific biosystem
      Regulation of CDC42 activity
    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton
    • Renal cell carcinoma, organism-specific biosystem (from KEGG)
      Renal cell carcinoma, organism-specific biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
    • Renal cell carcinoma, conserved biosystem (from KEGG)
      Renal cell carcinoma, conserved biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
    • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
      Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
    • RhoA signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      RhoA signaling pathway, organism-specific biosystem
      RhoA signaling pathway
    • S1P4 pathway, organism-specific biosystem (from Pathway Interaction Database)
      S1P4 pathway, organism-specific biosystem
      S1P4 pathway
    • Salmonella infection, organism-specific biosystem (from KEGG)
      Salmonella infection, organism-specific biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
    • Salmonella infection, conserved biosystem (from KEGG)
      Salmonella infection, conserved biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
    • Sema4D in semaphorin signaling, organism-specific biosystem (from REACTOME)
      Sema4D in semaphorin signaling, organism-specific biosystemSemaphorin 4D (Sema 4D/CD100) is an axon guidance molecule with two disulfide-linked 150-kDa subunits. SEMA4D is structurally defined by a conserved 500-amino acid extracellular domain with 16 cyste...
    • Sema4D induced cell migration and growth-cone collapse, organism-specific biosystem (from REACTOME)
      Sema4D induced cell migration and growth-cone collapse, organism-specific biosystemSema4D-mediated attraction of endothelial cells requires Rho, but not R-Ras, signaling. Sema4D-mediated plexinB1 activation activates Rho and its downstream effector ROCK. ROCK then phosphorylates ML...
    • Semaphorin interactions, organism-specific biosystem (from REACTOME)
      Semaphorin interactions, organism-specific biosystemSemaphorins are a large family of cell surface and secreted guidance molecules divided into eight classes on the basis of their structures. They all have an N-terminal conserved sema domain. Semaphor...
    • Shigellosis, organism-specific biosystem (from KEGG)
      Shigellosis, organism-specific biosystemShigellosis, or bacillary dysentery, is an intestinal infection caused by Shigella, a genus of enterobacteria. Shigella are potential food-borne pathogens that are capable of colonizing the intestina...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by EGFR, organism-specific biosystem (from REACTOME)
      Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...
    • Signaling by EGFR in Cancer, organism-specific biosystem (from REACTOME)
      Signaling by EGFR in Cancer, organism-specific biosystemThe pathway "Signaling by EGFR in Cancer" shows "Signaling by constitutively active EGFR" in parallel with "Signaling by EGFR". This allows users to compare signaling by constitutively active EGFR ca...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
      Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
    • Signaling by Robo receptor, organism-specific biosystem (from REACTOME)
      Signaling by Robo receptor, organism-specific biosystemThe Roundabout (Robo) family encodes transmembrane receptors that regulate axonal guidance and cell migration. The major function of the Robo receptors is to mediate repulsion of the navigating growt...
    • Signaling by Robo receptor, organism-specific biosystem (from REACTOME)
      Signaling by Robo receptor, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), organism-specific biosystem
      Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
    • Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem
      Signaling events mediated by VEGFR1 and VEGFR2
    • T Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      T Cell Receptor Signaling Pathway, organism-specific biosystem
      T Cell Receptor Signaling Pathway
    • T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
      T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • T cell receptor signaling pathway, conserved biosystem (from KEGG)
      T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • TCR signaling in naive CD4+ T cells, organism-specific biosystem (from Pathway Interaction Database)
      TCR signaling in naive CD4+ T cells, organism-specific biosystem
      TCR signaling in naive CD4+ T cells
    • Tight junction, organism-specific biosystem (from KEGG)
      Tight junction, organism-specific biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
    • Tight junction, conserved biosystem (from KEGG)
      Tight junction, conserved biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
    • VEGF signaling pathway, organism-specific biosystem (from KEGG)
      VEGF signaling pathway, organism-specific biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
    • VEGF signaling pathway, conserved biosystem (from KEGG)
      VEGF signaling pathway, conserved biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
    • p38 MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
      p38 MAPK Signaling Pathway, organism-specific biosystemp38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    GTP-dependent protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    GTPase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    mitogen-activated protein kinase kinase kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    thioesterase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    GTP catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    T cell costimulation TAS
    Traceable Author Statement
    more info
    		  
    actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    actin filament bundle assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    adherens junction organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    axon guidance TAS
    Traceable Author Statement
    more info
    		  
    blood coagulation TAS
    Traceable Author Statement
    more info
    		  
    canonical Wnt receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular protein localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    epidermal growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    epithelial cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    epithelial-mesenchymal cell signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    establishment or maintenance of apical/basal cell polarity IEA
    Inferred from Electronic Annotation
    more info
    		  
    establishment or maintenance of cell polarity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    filopodium assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    hair follicle morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    hair follicle placode formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    keratinization IEA
    Inferred from Electronic Annotation
    more info
    		  
    keratinocyte development IEA
    Inferred from Electronic Annotation
    more info
    		  
    macrophage differentiation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    muscle cell differentiation TAS
    Traceable Author Statement
    more info
    		  
    negative regulation of epidermal growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of protein complex assembly IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    neuron fate determination IEA
    Inferred from Electronic Annotation
    more info
    		  
    nuclear migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of JNK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of cell cycle cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of hair follicle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of muscle cell differentiation TAS
    Traceable Author Statement
    more info
    		  
    positive regulation of peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of phosphatidylinositol 3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of pseudopodium assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of attachment of spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of filopodium assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of mitosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of protein stability IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
    		  
    small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    apical part of cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    filopodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    intracellular IEA
    Inferred from Electronic Annotation
    more info
    		  
    microtubule organizing center IEA
    Inferred from Electronic Annotation
    more info
    		  
    midbody IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mitotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    secretory granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    spindle midzone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Help top of page

    General protein information

    Preferred Names
    cell division control protein 42 homolog
    Names
    cell division control protein 42 homolog
    G25K GTP-binding protein
    GTP-binding protein, 25kD
    growth-regulating protein
    small GTP binding protein CDC42
    dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD))
    dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD))
    NP_001034891.1
    NP_001782.1
    NP_426359.1
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039802.1 → NP_001034891.1  cell division control protein 42 homolog isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an additional exon in the 5' UTR and encodes the same isoform 1, compared to variant 1.
      Source sequence(s)
      AL031281, BC018266, BP871988
      Consensus CDS
      CCDS221.1
      UniProtKB/Swiss-Prot
      P60953
      Related
      ENSP00000341072, OTTHUMP00000002834, ENST00000344548, OTTHUMT00000007787
      Conserved Domains (1) summary
      cd01874
      Location:3 – 177
      Blast Score: 949
      Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family

    2. NM_001791.3 → NP_001782.1  cell division control protein 42 homolog isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1 which has the same aa length but different C-terminus from isoform 2.
      Source sequence(s)
      AL031281, BC018266, BP871988
      Consensus CDS
      CCDS221.1
      UniProtKB/Swiss-Prot
      P60953
      Related
      ENSP00000383118, ENST00000400259
      Conserved Domains (1) summary
      cd01874
      Location:3 – 177
      Blast Score: 949
      Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family

    3. NM_044472.2 → NP_426359.1  cell division control protein 42 homolog isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs from variant 1 at the 3' region including a small part of the coding region and the entire 3' UTR. This variant encodes isoform 2 which has the same aa length but different C-terminus from isoform 1.
      Source sequence(s)
      AL031281, BM684474, BP871988
      Consensus CDS
      CCDS222.1
      UniProtKB/Swiss-Prot
      P60953
      Related
      ENSP00000314458, OTTHUMP00000002926, ENST00000315554, OTTHUMT00000008075
      Conserved Domains (1) summary
      cd01874
      Location:3 – 177
      Blast Score: 947
      Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      22379120..22419436
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      20622960..20663212
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL031281.6 CAB52602.1
      CAD92551.1
      CAI19851.1
    genomic AY673602.1 AAT70721.1
    genomic CH471134.1 EAW95002.1
      EAW95003.1
      EAW95004.1
      EAW95005.1
      EAW95006.1
      EAW95007.1
      EAW95008.1
      EAW95009.1
    genomic CS026525.1 CAI61729.1
    mRNA AF498962.1 AAM21109.1
    mRNA AF498963.1 AAM21110.1
    mRNA AK297465.1 BAG59887.1
    mRNA AK303994.1 BAG64911.1
    mRNA AK311375.1 None
    mRNA AK316449.1 BAH14820.1
    mRNA AL121734.1 CAB57325.1
    mRNA AL121735.1 CAB57326.1
    mRNA AL121736.1 CAB57327.1
    mRNA AL121737.1 CAB57328.1
    mRNA BC002711.2 AAH02711.1
    mRNA BC003682.1 AAH03682.1
    mRNA BC018266.1 AAH18266.1
    mRNA BC018622.1 None
    mRNA BM684474.1 None
    mRNA BP871988.1 None
    mRNA M35543.1 AAA52494.1
    mRNA M57298.1 AAA52592.1
    other-genetic DQ891195.2 ABM82121.1
    other-genetic DQ894377.2 ABM85303.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P60953.2 GenPept UniProtKB/Swiss-Prot:P60953
    Q5JYX0 GenPept UniProtKB/TrEMBL:Q5JYX0
    Q9UJM0 GenPept UniProtKB/TrEMBL:Q9UJM0
    Q9UJM1 GenPept UniProtKB/TrEMBL:Q9UJM1
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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