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    CAV1 caveolin 1, caveolae protein, 22kDa [ Homo sapiens ]

    Gene ID: 857, updated on 20-May-2012
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    Summary

    Official Symbol
    CAV1provided by HGNC
    Official Full Name
    caveolin 1, caveolae protein, 22kDaprovided by HGNC
    Primary source
    HGNC:1527
    See related
    Ensembl:ENSG00000105974; HPRD:03028; MIM:601047; Vega:OTTHUMG00000023413
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CGL3; BSCL3; VIP21; MSTP085
    Summary
    The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010]
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    Genomic context

    Location :
    7q31.1
    Sequence :
    Chromosome: 7; NC_000007.13 (116164839..116201239)
    See CAV1 in Epigenomics, MapViewer

    Chromosome 7 - NC_000007.13Genomic Context describing neighboring genes Neighboring gene testis derived transcript (3 LIM domains) Neighboring gene caveolin 2 Neighboring gene met proto-oncogene (hepatocyte growth factor receptor) Neighboring gene KIAA1468 pseudogene Neighboring gene capping protein (actin filament) muscle Z-line, alpha 2

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. The interrelationships between Src, Cav-1 and RhoGD12 in transitional cell carcinoma of the bladder. Qayyum T, et al. Br J Cancer, 2012 Mar 13. PMID 22353809.
    2. Caveolin-1 attenuates hydrogen peroxide-induced oxidative damage to lung carcinoma cells. Suchaoin W, et al. Anticancer Res, 2012 Feb. PMID 22287735.
    3. Expression of caveolin-1, caveolin-2 and caveolin-3 in thyroid cancer and stroma. Kim D, et al. Pathobiology, 2012. PMID 22236542.
    4. Prognostic relevance of the expressions of CAV1 and TES genes on 7q31 in melanoma. Vizkeleti L, et al. Front Biosci (Elite Ed), 2012 Jan 1. PMID 22201996.
    5. A novel FoxM1-caveolin signaling pathway promotes pancreatic cancer invasion and metastasis. Huang C, et al. Cancer Res, 2012 Feb 1. PMID 22194465.

    See all (477) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. We hypothesise that it is the activity of Src that drives the relationship with Cav-1 and RhoGD12 expression in transition cell carcinoma of the bladder
      Title: The interrelationships between Src, Cav-1 and RhoGD12 in transitional cell carcinoma of the bladder.
    2. Alterations of TES mRNA level may predict the location of metastasis. CAV1 possibly affect the cancer cell invasion
      Title: Prognostic relevance of the expressions of CAV1 and TES genes on 7q31 in melanoma.
    3. Caveolin-1 knockdown by small interfering RNA reduces H2O2-induced SHP-2 phosphorylation in rat primary astrocytes and in CRT-MG human astroglioma cells.
      Title: Caveolin-1 is involved in reactive oxygen species-induced SHP-2 activation in astrocytes.
    4. Stromal caveolin-1 expression were more frequent in anaplastic carcinoma and diffuse sclerosing variant of papillary carcinoma compared to conventional papillary thyroid carcinoma.
      Title: Expression of caveolin-1, caveolin-2 and caveolin-3 in thyroid cancer and stroma.
    5. Over expression of caveolin-1 in the tumour cell cytoplasm predicts a poor prognosis of patients with clear cell RCC.
      Title: Caveolin 1 protein expression in renal cell carcinoma predicts survival.
    6. Findings show for the first time the upregulation of mRNA CAV-1 expression levels in VAT and SAT of obese NG and obese T2DM patients compared with lean controls, suggesting a role for CAV-1 in obesity and T2DM development.
      Title: Expression of caveolin-1 in human adipose tissue is upregulated in obesity and obesity-associated type 2 diabetes mellitus and related to inflammation.
    7. study identifies a new function for caveolin-1 in controlling smooth muscle phenotype; this mechanism could contribute to allergic asthma.
      Title: Caveolin-1 is required for contractile phenotype expression by airway smooth muscle cells.
    8. sensitivity of non-small-cell lung cancer cells to metformin was dependent on Cav-1 expression
      Title: Caveolin-1 is essential for metformin inhibitory effect on IGF1 action in non-small-cell lung cancer cells.
    9. Arterial remodeling was associated with number of G alleles of CAV-1 polymorphism, GG homozygotes displaying intimal-media thickness and carotid cross-sectional area that were, respectively, 16% and 21% higher than those in patients without risk allele
      Title: eNOS and caveolin-1 gene polymorphisms interaction and intima media thickness: a proof of concept study in ESRD patients.
    10. loss of CAV1 mRNA expression may play a role in prostate cancer progression.
      Title: Expression of endothelial factors in prostate cancer: a possible role of caveolin-1 for tumour progression.
    Submit: New GeneRIF Correction See all (363)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma.

    Genome-wide association study of PR interval.

    Lipodystrophy, congenital generalized, type 3

    Several common variants modulate heart rate, PR interval and QRS duration.

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 forms a stable complex with caveolin-1 through its amino-acid residues 623-631 in HIV-infected cells; antibodies to the caveolin-1 binding domain in gp41 inhibit virus infectivity PubMed
    env Amino acid residues 61-101 of caveolin 1 are involved in the binding of caveolin 1 to the N36(L8)C34 domain of gp41 PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    CAA79476.1 Q13418 ILK    BIND  PubMed ILK1 interacts with caveolin-1. 
    NP_001744.2 NP_000035.2 AR    BIND  PubMed Caveolin-1 interacts with AR. 
    NP_001744.2 NP_001744.2 CAV1    BIND  PubMed CAV1 (caveolin-1) homodimerizes. 
    NP_001744.2 NP_004351.1 CDH1    BIND  PubMed E-cadherin interacts with caveolin-1. 
    NP_001744.2 NP_002699.1 PPP1CA    BIND  PubMed CAV1 interacts with PP1-C. 
    NP_001744.2 P60484 PTEN    BIND  PubMed caveolin-1 interacts with PTEN. 
    NP_001744.2 NP_002818.1 PTPN1    BIND  PubMed caveolin-1 interacts with PTP1B. 
    NP_001744.2 NP_002825.3 PTPN11    BIND  PubMed caveolin-1 interacts with SH-PTP2. 
    NP_001744.2 NP_536858.1 PTPN6    BIND  PubMed caveolin-1 interacts with PTP-1C. 
    NP_001744.2 NP_002831.1 PTPRF    BIND  PubMed caveolin-1 interacts with LAR. 
    Q03135 P08183 ABCB1    HPRD  PubMed  
    Q03135 P25098 ADRBK1    HPRD  PubMed  
    Q03135 Q92667 AKAP1    HPRD  PubMed  
    Q03135 P05067 APP    HPRD  PubMed  
    Q03135 P10275 AR    HPRD  PubMed  
    Q03135 P51813 BMX    HPRD  PubMed  
    Q03135 P35613 BSG    HPRD  PubMed  
    Q03135 Q10588 BST1    HPRD  PubMed  
    Q03135 Q06187 BTK    HPRD  PubMed  
    Q03135 Q03135 CAV1    HPRD  PubMed  
    Q03135 P51636 CAV2    HPRD  PubMed  
    Q03135 P25942 CD40    HPRD  PubMed  
    Q03135 P41240 CSK    HPRD  PubMed  
    Q03135 P68400 CSNK2A1    HPRD  PubMed  
    Q03135 P19784 CSNK2A2    HPRD  PubMed  
    Q03135 Q05193 DNM1    HPRD  PubMed  
    Q03135 P24530 EDNRB    HPRD  PubMed  
    Q03135 P00533 EGFR    HPRD  PubMed  
    Q03135 P04626 ERBB2    HPRD  PubMed  
    Q03135 P03372 ESR1    HPRD  PubMed  
    Q03135 P21333 FLNA    HPRD  PubMed  
    Q03135 Q14254 FLOT2    HPRD  PubMed  
    Q03135 P06241 FYN    HPRD  PubMed  
    Q03135 P17302 GJA1    HPRD  PubMed  
    Q03135 Q9Y6H8 GJA3    HPRD  PubMed  
    Q03135 P29033 GJB2    HPRD  PubMed  
    Q03135 P04899 GNAI2    HPRD  PubMed  
    Q03135 Q14451 GRB7    HPRD  PubMed  
    Q03135 Q15835 GRK1    HPRD  PubMed  
    Q03135 P34947 GRK5    HPRD  PubMed  
    Q03135 P01112 HRAS    HPRD  PubMed  
    Q03135 P30939 HTR1F    HPRD  PubMed  
    Q03135 P17936 IGFBP3    HPRD  PubMed  
    Q03135 Q13418 ILK    HPRD  PubMed  
    Q03135 P06213 INSR    HPRD  PubMed  
    Q03135 P35568 IRS1    HPRD  PubMed  
    Q03135 P35968 KDR    HPRD  PubMed  
    Q03135 Q07954 LRP1    HPRD  PubMed  
    Q03135 Q13021 MALL    HPRD  PubMed  
    Q03135 P28482 MAPK1    HPRD  PubMed  
    Q03135 P27361 MAPK3    HPRD  PubMed  
    Q03135 P50281 MMP14    HPRD  PubMed  
    Q03135 Q9UQ49 NEU3    HPRD  PubMed  
    Q03135 P08138 NGFR    HPRD  PubMed  
    Q03135 P35228 NOS2    HPRD  PubMed  
    Q03135 P29474 NOS3    HPRD  PubMed  
    Q03135 P04629 NTRK1    HPRD  PubMed  
    Q03135 P16234 PDGFRA    HPRD  PubMed  
    Q03135 Q13393 PLD1    HPRD  PubMed  
    Q03135 O14939 PLD2    HPRD  PubMed  
    Q03135 P04156 PRNP    HPRD  PubMed  
    Q03135 P60484 PTEN    HPRD  PubMed  
    Q03135 P35354 PTGS2    HPRD  PubMed  
    Q03135 P18031 PTPN1    HPRD  PubMed  
    Q03135 Q06124 PTPN11    HPRD  PubMed  
    Q03135 P29350 PTPN6    HPRD  PubMed  
    Q03135 P10586 PTPRF    HPRD  PubMed  
    Q03135 P35243 RCVRN    HPRD  PubMed  
    Q03135 P61586 RHOA    HPRD  PubMed  
    Q03135 P21453 S1PR1    HPRD  PubMed  
    Q03135 P22307 SCP2    HPRD  PubMed  
    Q03135 P12931 SRC    HPRD  PubMed  
    Q03135 Q8TAV4 STOML3    HPRD  PubMed  
    Q03135 O43815 STRN    HPRD  PubMed  
    Q03135 Q9NRL3 STRN4    HPRD  PubMed  
    Q03135 P36897 TGFBR1    HPRD  PubMed  
    Q03135 P20333 TNFRSF1B    HPRD  PubMed  
    Q03135 Q12933 TRAF2    HPRD  PubMed  
    Q03135 Q9Y4K3 TRAF6    HPRD  PubMed  
    Q03135 P48995 TRPC1    HPRD  PubMed  
    BioGRID:107305 BioGRID:106665 ADRBK1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107305 BioGRID:106848 APP    BioGRID  PubMed Co-fractionation; Protein-RNA 
    BioGRID:107305 BioGRID:106856 AQP3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107305 BioGRID:106862 AR    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107305 BioGRID:107128 BMX    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107305 BioGRID:107160 BTK    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107305 BioGRID:107306 CAV2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107305 BioGRID:107832 CSK    BioGRID  PubMed Two-hybrid 
    BioGRID:107305 BioGRID:249813 Clic4    BioGRID  PubMed Co-fractionation 
    BioGRID:107305 BioGRID:107975 DAG1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107305 BioGRID:108232 EDNRB    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107305 BioGRID:108276 EGFR    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107305 BioGRID:108403 ESR1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107305 BioGRID:115506 FLOT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107305 BioGRID:108608 FLOT2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107305 BioGRID:108964 GJA1    BioGRID  PubMed Affinity Capture-Western; Co-fractionation; Reconstituted Complex 
    BioGRID:107305 BioGRID:108971 GJB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107305 BioGRID:108972 GJB2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107305 BioGRID:111943 GRK1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107305 BioGRID:109127 GRK5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107305 BioGRID:109854 INSR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107305 BioGRID:111580 MAPK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107305 BioGRID:111581 MAPK3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107305 BioGRID:116038 NEU3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107305 BioGRID:110870 NGFR    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107305 BioGRID:124517 NKD2    BioGRID  PubMed Co-fractionation 
    BioGRID:107305 BioGRID:110906 NOS2    BioGRID  PubMed Co-fractionation; Reconstituted Complex 
    BioGRID:107305 BioGRID:110909 NOS3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107305 BioGRID:110969 NTRK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107305 BioGRID:111182 PDGFRA    BioGRID  PubMed Affinity Capture-Western; Co-fractionation; Reconstituted Complex 
    BioGRID:107305 BioGRID:111185 PDGFRB    BioGRID  PubMed Affinity Capture-Western; Co-fractionation; Reconstituted Complex 
    BioGRID:107305 BioGRID:111354 PLD2    BioGRID  PubMed Affinity Capture-Western; Co-fractionation 
    BioGRID:107305 BioGRID:111553 PRKACA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107305 BioGRID:111700 PTEN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107305 BioGRID:111715 PTGS2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107305 BioGRID:111736 PTPN1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107305 BioGRID:111745 PTPN11    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107305 BioGRID:111742 PTPN6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107305 BioGRID:111756 PTPRF    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107305 BioGRID:111817 RAC1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107305 BioGRID:111890 RCVRN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107305 BioGRID:106880 RHOA    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107305 BioGRID:106882 RHOC    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107305 BioGRID:108225 S1PR1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107305 BioGRID:112246 SCP2    BioGRID  PubMed Affinity Capture-Western; FRET; Two-hybrid 
    BioGRID:107305 BioGRID:110262 SMAD2    BioGRID  PubMed Co-fractionation 
    BioGRID:107305 BioGRID:112592 SRC    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107305 BioGRID:112904 TGFBR1    BioGRID  PubMed Affinity Capture-Western; Co-fractionation 
    BioGRID:107305 BioGRID:112979 TNF    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107305 BioGRID:112986 TNFRSF1A    BioGRID  PubMed Co-fractionation 
    BioGRID:107305 BioGRID:112987 TNFRSF1B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107305 BioGRID:114257 TRADD    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107305 BioGRID:113038 TRAF2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107305 BioGRID:113071 TRPC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107305 BioGRID:113100 TSC2    BioGRID  PubMed Co-purification 
    BioGRID:107305 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • ALK1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      ALK1 signaling events, organism-specific biosystem
      ALK1 signaling events
    • Androgen Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Androgen Receptor Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
    • Bacterial invasion of epithelial cells, organism-specific biosystem (from KEGG)
      Bacterial invasion of epithelial cells, organism-specific biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
    • Bacterial invasion of epithelial cells, conserved biosystem (from KEGG)
      Bacterial invasion of epithelial cells, conserved biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
    • Basigin interactions, organism-specific biosystem (from REACTOME)
      Basigin interactions, organism-specific biosystemBasigin is a widely expressed transmembrane glycoprotein that belongs to the Ig superfamily and is highly enriched on the surface of epithelial cells. Basigin is involved in intercellular interaction...
    • Canonical Wnt signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      Canonical Wnt signaling pathway, organism-specific biosystem
      Canonical Wnt signaling pathway
    • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
      Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
    • Direct p53 effectors, organism-specific biosystem (from Pathway Interaction Database)
      Direct p53 effectors, organism-specific biosystem
      Direct p53 effectors
    • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis, organism-specific biosystem (from REACTOME)
      Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis, organism-specific biosystemTriacylglycerol is a major energy store in the body and its hydrolysis to yield fatty acids and glycerol is a tightly regulated part of energy metabolism. A central part in this regulation is played ...
    • Insulin Pathway, organism-specific biosystem (from Pathway Interaction Database)
      Insulin Pathway, organism-specific biosystem
      Insulin Pathway
    • Integrin-mediated cell adhesion, organism-specific biosystem (from WikiPathways)
      Integrin-mediated cell adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...
    • Lipid digestion, mobilization, and transport, organism-specific biosystem (from REACTOME)
      Lipid digestion, mobilization, and transport, organism-specific biosystemProcesses annotated here include the digestion of dietary lipids, sterol uptake, the formation and turnover of lipoproteins (chylomicrons, VLDL, LDL, and HDL), and the mobilization of fatty acids thr...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • Metabolism of nitric oxide, organism-specific biosystem (from REACTOME)
      Metabolism of nitric oxide, organism-specific biosystemNitric oxide (NO), a multifunctional second messenger, is implicated in physiological functions in mammals that range from immune response and potentiation of synaptic transmission to dilation of blo...
    • NOSTRIN mediated eNOS trafficking, organism-specific biosystem (from REACTOME)
      NOSTRIN mediated eNOS trafficking, organism-specific biosystemeNOS traffic inducer (NOSTRIN) is a novel 506-amino acid eNOS-interacting protein. Along with a decrease in eNOS activity, NOSTRIN causes translocation of eNOS from the plasma membrane to intracellu...
    • PDGFR-alpha signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      PDGFR-alpha signaling pathway, organism-specific biosystem
      PDGFR-alpha signaling pathway
    • Signaling events mediated by PTP1B, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by PTP1B, organism-specific biosystem
      Signaling events mediated by PTP1B
    • Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem
      Signaling events mediated by VEGFR1 and VEGFR2
    • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Receptor Signaling Pathway, organism-specific biosystem"The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. Th...
    • TGF-beta receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
      TGF-beta receptor signaling, organism-specific biosystem
      TGF-beta receptor signaling
    • TNF receptor signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      TNF receptor signaling pathway, organism-specific biosystem
      TNF receptor signaling pathway
    • TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem"The Tumor Necrosis Factor alpha is a proinflammatory cytokine belonging to the TNF superfamily. It signals through 2 separate receptors - TNFRSF1A and TNFRSF1B, both members of the TNF receptor supe...
    • VEGFR1 specific signals, organism-specific biosystem (from Pathway Interaction Database)
      VEGFR1 specific signals, organism-specific biosystem
      VEGFR1 specific signals
    • Viral myocarditis, organism-specific biosystem (from KEGG)
      Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...
    • eNOS activation, organism-specific biosystem (from REACTOME)
      eNOS activation, organism-specific biosystemeNOS activity is regulated by numerous post-translational modifications including phosphorylation and acylation, which also modulate its interactions with other proteins and its subcellular localizat...
    • eNOS activation and regulation, organism-specific biosystem (from REACTOME)
      eNOS activation and regulation, organism-specific biosystemOriginally identified as endothelium-derived relaxing factor, eNOS derived NO is a critical signaling molecule in vascular homeostasis. It regulates blood pressure and vascular tone, and is involved...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cholesterol binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nitric-oxide synthase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    patched binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    peptidase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein complex scaffold TAS
    Traceable Author Statement
    more info
    		 PubMed 
    receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    structural molecule activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    syntaxin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    T cell costimulation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    blood coagulation TAS
    Traceable Author Statement
    more info
    		  
    calcium ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    calcium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    caveola assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    caveolin-mediated endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cellular calcium ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cellular response to hyperoxia IMP
    Inferred from Mutant Phenotype
    more info
    		  
    cellular response to starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    cholesterol efflux IEA
    Inferred from Electronic Annotation
    more info
    		  
    cholesterol homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cholesterol homeostasis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cholesterol transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cytosolic calcium ion homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    inactivation of MAPK activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    induction of apoptosis by extracellular signals IMP
    Inferred from Mutant Phenotype
    more info
    		  
    interspecies interaction between organisms IEA
    Inferred from Electronic Annotation
    more info
    		  
    lactation IEA
    Inferred from Electronic Annotation
    more info
    		  
    leukocyte migration TAS
    Traceable Author Statement
    more info
    		  
    lipid storage ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    maintenance of protein location in cell ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    mammary gland development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    mammary gland involution ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    membrane depolarization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    negative regulation of BMP signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of JAK-STAT cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    negative regulation of MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    negative regulation of canonical Wnt receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    negative regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of endothelial cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    negative regulation of epithelial cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    negative regulation of nitric oxide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    negative regulation of peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of transcription from RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    negative regulation of tyrosine phosphorylation of Stat5 protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    nitric oxide homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    nitric oxide metabolic process TAS
    Traceable Author Statement
    more info
    		  
    positive regulation of anti-apoptosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of calcium ion transport into cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    positive regulation of canonical Wnt receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		  
    positive regulation of intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		  
    positive regulation of metalloenzyme activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of microtubule polymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of vasoconstriction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    protein homooligomerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    receptor internalization involved in canonical Wnt receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of blood coagulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of fatty acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    regulation of nitric-oxide synthase activity TAS
    Traceable Author Statement
    more info
    		  
    regulation of peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    regulation of smooth muscle contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    response to calcium ion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    response to drug IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to estrogen stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to gamma radiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to glucocorticoid stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to hypoxia ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to nutrient IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to progesterone stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    skeletal muscle tissue development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    small molecule metabolic process TAS
    Traceable Author Statement
    more info
    		  
    triglyceride metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    vasculogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    vesicle organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Golgi membrane TAS
    Traceable Author Statement
    more info
    		  
    acrosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    basal plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    caveola IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    caveola NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
    		  
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    endosome IDA
    Inferred from Direct Assay
    more info
    		  
    flagellum IEA
    Inferred from Electronic Annotation
    more info
    		  
    focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to membrane of membrane fraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    intracellular IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    lipid particle TAS
    Traceable Author Statement
    more info
    		  
    membrane raft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    soluble fraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    caveolin-1
    Names
    caveolin-1
    cell growth-inhibiting protein 32
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012051.1 RefSeqGene

      Range
      5001..41401
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001172895.1 → NP_001166366.1  caveolin-1 isoform beta

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (beta) is shorter than isoform alpha. Variants 2, 3 and 4 encode the same isoform.
      Source sequence(s)
      AB209926, AC006159, AK290871, BC006432, BG170208, DB266251
      Consensus CDS
      CCDS55156.1
      UniProtKB/TrEMBL
      Q2TNI1
      UniProtKB/TrEMBL
      Q59E85
      Related
      ENSP00000384348, OTTHUMP00000198308, ENST00000405348, OTTHUMT00000319688
      Conserved Domains (1) summary
      pfam01146
      Location:3 – 146
      Blast Score: 599
      Caveolin; Caveolin

    2. NM_001172896.1 → NP_001166367.1  caveolin-1 isoform beta

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (beta) is shorter than isoform alpha. Variants 2, 3 and 4 encode the same isoform.
      Source sequence(s)
      AB209926, AC006159, AF172085, AK290871, BG170208, DA943080
      Consensus CDS
      CCDS55156.1
      UniProtKB/TrEMBL
      Q2TNI1
      UniProtKB/TrEMBL
      Q59E85
      UniProtKB/TrEMBL
      Q7Z4F3
      Related
      ENSP00000377110, OTTHUMP00000195988, ENST00000393467, OTTHUMT00000141424
      Conserved Domains (1) summary
      pfam01146
      Location:3 – 146
      Blast Score: 599
      Caveolin; Caveolin

    3. NM_001172897.1 → NP_001166368.1  caveolin-1 isoform beta

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (beta) is shorter than isoform alpha. Variants 2, 3 and 4 encode the same isoform.
      Source sequence(s)
      AB209926, AC006159, AK290871, BG170208, DA477166, EF649773
      Consensus CDS
      CCDS55156.1
      UniProtKB/TrEMBL
      A9XTE5
      UniProtKB/TrEMBL
      Q2TNI1
      UniProtKB/TrEMBL
      Q59E85
      Related
      ENSP00000377111, OTTHUMP00000195989, ENST00000393468, OTTHUMT00000141425
      Conserved Domains (1) summary
      pfam01146
      Location:3 – 146
      Blast Score: 599
      Caveolin; Caveolin

    4. NM_001753.4 → NP_001744.2  caveolin-1 isoform alpha

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (alpha).
      Source sequence(s)
      AB209926, AC006159, AI878826, AK290871, BG170208
      Consensus CDS
      CCDS5767.1
      UniProtKB/Swiss-Prot
      Q03135
      UniProtKB/TrEMBL
      Q2TNI1
      UniProtKB/TrEMBL
      Q59E85
      Related
      ENSP00000339191, OTTHUMP00000025031, ENST00000341049, OTTHUMT00000059734
      Conserved Domains (1) summary
      pfam01146
      Location:34 – 177
      Blast Score: 621
      Caveolin; Caveolin

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000007.13 Reference GRCh37.p5 Primary Assembly

      Range
      116164839..116201239
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000139.1 Alternate HuRef

      Range
      110530835..110566784
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CRA_TCAGchr7v2

    Genomic

    1. AC_000068.1 Alternate CRA_TCAGchr7v2

      Range
      115560275..115596679
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC006159.3 (29979..66370) None
    genomic AF019742.1 AAB82538.1
    genomic AF095591.1 AAD23745.1
    genomic AF095592.1 AAD23745.1
    genomic AF095593.1 AAD23745.1
    genomic AF125348.1 AAD34722.1
    genomic AJ133269.1 CAB63654.1
    genomic CH236947.1 EAL24360.1
    genomic CH471070.1 EAW83503.1
      EAW83504.1
      EAW83505.1
    mRNA AB209926.1 BAD93163.1
    mRNA AB451284.1 BAG70098.1
    mRNA AB451416.1 BAG70230.1
    mRNA AF070648.1 None
    mRNA AF074993.1 None
    mRNA AF172085.1 AAQ13608.1
    mRNA AI878826.1 None
    mRNA AK290871.1 BAF83560.1
    mRNA AK307501.1 None
    mRNA AL133639.1 None
    mRNA AY762103.1 AAX07830.1
    mRNA BC006432.1 None
    mRNA BC009685.1 AAH09685.1
    mRNA BC082246.1 AAH82246.1
    mRNA BG170208.1 None
    mRNA BT007143.1 AAP35807.1
    mRNA DA477166.1 None
    mRNA DA943080.1 None
    mRNA DB266251.1 None
    mRNA EF179102.1 None
    mRNA EF649773.1 ABW22625.1
    mRNA EF649774.1 ABW22626.1
    mRNA Z18951.1 CAA79476.1
    other-genetic AM393679.1 CAL38555.1
    other-genetic DQ890647.2 ABM81573.1
    other-genetic DQ893827.2 ABM84753.1
    other-genetic EU176473.1 ABW03274.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03135.4 GenPept UniProtKB/Swiss-Prot:Q03135
    Q2TNI1 GenPept UniProtKB/TrEMBL:Q2TNI1
    Q59E85 GenPept UniProtKB/TrEMBL:Q59E85
    Q71VB8 GenPept UniProtKB/TrEMBL:Q71VB8
    Q7Z4F3 GenPept UniProtKB/TrEMBL:Q7Z4F3
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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