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    ZAP70 zeta-chain (TCR) associated protein kinase 70kDa [ Homo sapiens ]

    Gene ID: 7535, updated on 19-May-2012
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    Summary

    Official Symbol
    ZAP70provided by HGNC
    Official Full Name
    zeta-chain (TCR) associated protein kinase 70kDaprovided by HGNC
    Primary source
    HGNC:12858
    See related
    Ensembl:ENSG00000115085; HPRD:01495; MIM:176947; Vega:OTTHUMG00000153060
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SRK; STD; TZK; ZAP-70; FLJ17670; FLJ17679
    Summary
    This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    2q12
    Sequence :
    Chromosome: 2; NC_000002.11 (98330031..98356323)
    See ZAP70 in Epigenomics, MapViewer

    Chromosome 2 - NC_000002.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC728537 Neighboring gene RNA, U4 small nuclear 8, pseudogene Neighboring gene transmembrane protein 131 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 36 Neighboring gene von Willebrand factor A domain containing 3B Neighboring gene ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide pseudogene 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. [Prognostic significance of new biological markers in chronic lymphocytic leukaemia]. Leković D, et al. Srp Arh Celok Lek, 2011 Nov-Dec. PMID 22338471.
    2. Defining the prognosis of early stage chronic lymphocytic leukaemia patients. Pepper C, et al. Br J Haematol, 2012 Feb. PMID 22171799.
    3. Analysis of CD38 and ZAP70 mRNA expression among cytogenetic subgroups of Iranian chronic-lymphocytic-leukemia patients. Teimori H, et al. Genet Mol Res, 2011 Oct 7. PMID 22002134.
    4. Carbonyl group serum levels are associated with CD38 expression in patients with B chronic lymphocytic leukemia. Musolino C, et al. Clin Biochem, 2011 Dec. PMID 21945028.
    5. Spatial association of signaling proteins and F-actin effects on cluster assembly analyzed via photoactivation localization microscopy in T cells. Hsu CJ, et al. PLoS One, 2011. PMID 21887278.

    See all (215) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. ZAP-70 expression and FISH were not independent prognostic markers in early stage chronic lymphocytic leukaemia (CLL).
      Title: Defining the prognosis of early stage chronic lymphocytic leukaemia patients.
    2. Data show that CD27(+)/IgD(-)/ZAP70(+) memory B cells accumulate preferentially in the joints of RA, suggesting a dynamic maturation of the B cells in this compartment.
      Title: B-cell subsets in the joint compartments of seropositive and seronegative rheumatoid arthritis (RA) and No-RA arthritides express memory markers and ZAP70 and characterize the aggregate pattern irrespectively of the autoantibody status.
    3. expression of CD38 antigen and ZAP-70 have an exceptional significance in the prediction of prognosis in CLL patients.
      Title: [Prognostic significance of new biological markers in chronic lymphocytic leukaemia].
    4. We found a positive correlation between blood protein carbonyl groups with CD38 expression and a negative correlation with ZAP 70 expression
      Title: Carbonyl group serum levels are associated with CD38 expression in patients with B chronic lymphocytic leukemia.
    5. Analysis of CD38 and ZAP70 mRNA expression among cytogenetic subgroups of Iranian chronic-lymphocytic-leukemia patients.
      Title: Analysis of CD38 and ZAP70 mRNA expression among cytogenetic subgroups of Iranian chronic-lymphocytic-leukemia patients.
    6. The spatial correlation between kinase ZAP70 and adaptor SLP76 microclusters (MC) at the cell periphery and the effects of F-actin on MC assembly, were analysed.
      Title: Spatial association of signaling proteins and F-actin effects on cluster assembly analyzed via photoactivation localization microscopy in T cells.
    7. Data indicate that high iLR expression was strongly correlated with negativity for CD38 and ZAP-70 expression and mutated IGVH gene status.
      Title: High expression of the immature laminin receptor protein correlates with mutated IGVH status and predicts a favorable prognosis in chronic lymphocytic leukemia.
    8. The determination of TK, ZAP-70 and CD38 together allows patients susceptible to a possible stage of the disease, to be identified.
      Title: Identifying the stage of new CLL patients using TK, ZAP-70, CD38 levels.
    9. SDF-1 treatment of T cells induced the formation of a novel molecular signaling complex containing RasGRP1, Galphai2, and ZAP-70.
      Title: G alpha i2 and ZAP-70 mediate RasGRP1 membrane localization and activation of SDF-1-induced T cell functions.
    10. Data show there was no correlation between the MDR1 genotypes and Binet stage, unmutated immunoglobulin heavy-chain variable region (IGHV) status, CD38 expression, ZAP-70 expression, and p53 deletion.
      Title: Polymorphisms and haplotypes in multidrug resistance 1 gene are not associated with chronic lymphocytic leukemia susceptibility and prognostic parameters of chronic lymphocytic leukemia in Chinese population.
    Submit: New GeneRIF Correction See all (123)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Selective T-cell defect

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Binding of HIV-1 gp120 to CD4 induces p56lck activation and zeta-chain (TCR) associated protein kinase 70kDa desensitization independent of TCR tyrosine phosphorylation PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 alone or CD4/gp160 cross-linking induces tyrosine phosphorylation of intracellular substrates p59fyn, zap 70, and p95vav and also leads to ras activation PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001070.2 NP_005197.3 CRK    BIND  PubMed ZAP-70 interacts with Crk-I. 
    NP_001070.2 NP_058431.2 CRK    BIND  PubMed ZAP-70 interacts with Crk-II. 
    NP_001070.2 NP_005198.1 CRKL    BIND  PubMed ZAP-70 interacts with CrkL. This interaction was modeled on a demonstrated interaction between human ZAP-70 and CrkL from an unspecified species. 
    NP_001070.2 NP_001070.2 ZAP70    BIND  PubMed ZAP70 autophosphorylates. 
    P43403 P00519 ABL1    HPRD  PubMed  
    P43403 P24666 ACP1    HPRD  PubMed  
    P43403 Q9BXL7 CARD11    HPRD  PubMed  
    P43403 P22681 CBL    HPRD  PubMed  
    P43403 Q13191 CBLB    HPRD  PubMed  
    P43403 P20963 CD247    HPRD  PubMed  
    P43403 P07766 CD3E    HPRD  PubMed  
    P43403 P06127 CD5    HPRD  PubMed  
    P43403 P40259 CD79B    HPRD  PubMed  
    P43403 P46108 CRK    HPRD  PubMed  
    P43403 Q9UJU6 DBNL    HPRD  PubMed  
    P43403 DEF6 DEF6    HPRD  PubMed  
    P43403 P51452 DUSP3    HPRD  PubMed  
    P43403 P08637 FCGR3A    HPRD  PubMed  
    P43403 Fc receptor like protein 3 FCRL3    HPRD  PubMed  
    P43403 P06241 FYN    HPRD  PubMed  
    P43403 Q9UQC2 GAB2    HPRD  PubMed  
    P43403 P62993 GRB2    HPRD  PubMed  
    P43403 P17181 IFNAR1    HPRD  PubMed  
    P43403 O43561 LAT    HPRD  PubMed  
    P43403 Q8IWV1 LAX1    HPRD  PubMed  
    P43403 P06239 LCK    HPRD  PubMed  
    P43403 Q13094 LCP2    HPRD  PubMed  
    P43403 P15941 MUC1    HPRD  PubMed  
    P43403 Q8NET5 NFAM1    HPRD  PubMed  
    P43403 Q9NWQ8 PAG1    HPRD  PubMed  
    P43403 P19174 PLCG1    HPRD  PubMed  
    P43403 P16471 PRLR    HPRD  PubMed  
    P43403 Q14289 PTK2B    HPRD  PubMed  
    P43403 Q9Y2R2 PTPN22    HPRD  PubMed  
    P43403 P26045 PTPN3    HPRD  PubMed  
    P43403 P29350 PTPN6    HPRD  PubMed  
    P43403 P08575 PTPRC    HPRD  PubMed  
    P43403 P20936 RASA1    HPRD  PubMed  
    P43403 Q9UQQ2 SH2B3    HPRD  PubMed  
    P43403 P78314 SH3BP2    HPRD  PubMed  
    P43403 Q15464 SHB    HPRD  PubMed  
    P43403 P29353 SHC1    HPRD  PubMed  
    P43403 Q9Y3P8 SIT1    HPRD  PubMed  
    P43403 Q13239 SLA    HPRD  PubMed  
    P43403 Q9H6Q3 SLA2    HPRD  PubMed  
    P43403 Q96DU3 SLAMF6    HPRD  PubMed  
    P43403 Q07889 SOS1    HPRD  PubMed  
    P43403 P68366 TUBA4A    HPRD  PubMed  
    P43403 P07437 TUBB    HPRD  PubMed  
    P43403 O43914 TYROBP    HPRD  PubMed  
    P43403 P15498 VAV1    HPRD  PubMed  
    P43403 O43516 WIPF1    HPRD  PubMed  
    P43403 P43403 ZAP70    HPRD  PubMed  
    BioGRID:113367 BioGRID:106543 ABL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113367 BioGRID:106568 ACP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113367 BioGRID:107315 CBL    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure 
    BioGRID:113367 BioGRID:107316 CBLB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113367 BioGRID:107357 CD247    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113367 BioGRID:107354 CD3E    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113367 BioGRID:107358 CD4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113367 BioGRID:107359 CD5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113367 BioGRID:107788 CRK    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113367 BioGRID:198596 Cd3e    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113367 BioGRID:118809 DBNL    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:113367 BioGRID:125428 FCRL3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113367 BioGRID:108810 FYN    BioGRID  PubMed Affinity Capture-Western; Phenotypic Enhancement 
    BioGRID:113367 BioGRID:115181 GAB2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113367 BioGRID:109142 GRB2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113367 BioGRID:109540 HSPA4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113367 BioGRID:117971 LAT    BioGRID  PubMed Biochemical Activity 
    BioGRID:113367 BioGRID:110124 LCK    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113367 BioGRID:110129 LCP2    BioGRID  PubMed Biochemical Activity 
    BioGRID:113367 BioGRID:120931 PAG1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113367 BioGRID:111351 PLCG1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113367 BioGRID:111742 PTPN6    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113367 BioGRID:111856 RASA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113367 BioGRID:112350 SH3BP2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113367 BioGRID:112358 SHB    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113367 BioGRID:112361 SHC1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:113367 BioGRID:118088 SIT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113367 BioGRID:112394 SLA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113367 BioGRID:123928 SLA2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113367 BioGRID:113603 TUBA1A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113367 BioGRID:115651 TUBA1B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113367 BioGRID:128444 TUBB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113367 BioGRID:113155 TYROBP    BioGRID  PubMed Protein-peptide 
    BioGRID:113367 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113367 BioGRID:113252 VAV1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113367 BioGRID:1205541 tat    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Genotypes

    Homology

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ?? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation o...
    • Generation of second messenger molecules, organism-specific biosystem (from REACTOME)
      Generation of second messenger molecules, organism-specific biosystemIn addition to serving as a scaffold via auto-phosphorylation, ZAP-70 also phosphorylates a restricted set of substrates following TCR stimulation - including LAT and SLP-76. These substrates have be...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Inflammatory Response Pathway, organism-specific biosystem (from WikiPathways)
      Inflammatory Response Pathway, organism-specific biosystem
      Inflammatory Response Pathway
    • Natural killer cell mediated cytotoxicity, organism-specific biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, organism-specific biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Natural killer cell mediated cytotoxicity, conserved biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, conserved biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Primary immunodeficiency, organism-specific biosystem (from KEGG)
      Primary immunodeficiency, organism-specific biosystemPrimary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells ...
    • Primary immunodeficiency, conserved biosystem (from KEGG)
      Primary immunodeficiency, conserved biosystemPrimary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells ...
    • T Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      T Cell Receptor Signaling Pathway, organism-specific biosystem
      T Cell Receptor Signaling Pathway
    • T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
      T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • T cell receptor signaling pathway, conserved biosystem (from KEGG)
      T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • TCR signaling, organism-specific biosystem (from REACTOME)
      TCR signaling, organism-specific biosystemThe TCR is a multisubunit complex that consists of clonotypic alpha/beta chains noncovalently associated with the invariant CD3 delta/epsilon/gamma and TCR zeta chains. T cell activation by antigen p...
    • TCR signaling in naive CD4+ T cells, organism-specific biosystem (from Pathway Interaction Database)
      TCR signaling in naive CD4+ T cells, organism-specific biosystem
      TCR signaling in naive CD4+ T cells
    • TCR signaling in naive CD8+ T cells, organism-specific biosystem (from Pathway Interaction Database)
      TCR signaling in naive CD8+ T cells, organism-specific biosystem
      TCR signaling in naive CD8+ T cells
    • Translocation of ZAP-70 to Immunological synapse, organism-specific biosystem (from REACTOME)
      Translocation of ZAP-70 to Immunological synapse, organism-specific biosystemThe dual phosphorylated ITAMs recruit Syk kinase ZAP-70 via their tandem SH2 domains (step 4). ZAP-70 subsequently undergoes phosphorylation on multiple tyrosine residues for further activation. ZAP-...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    non-membrane spanning protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein tyrosine kinase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    B cell activation TAS
    Traceable Author Statement
    more info
    		  
    T cell activation TAS
    Traceable Author Statement
    more info
    		  
    T cell aggregation TAS
    Traceable Author Statement
    more info
    		  
    T cell differentiation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    T cell migration TAS
    Traceable Author Statement
    more info
    		  
    T cell receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    adaptive immune response TAS
    Traceable Author Statement
    more info
    		  
    immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    intracellular protein kinase cascade NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    positive regulation of T cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive thymic T cell selection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein phosphorylation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    T cell receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    tyrosine-protein kinase ZAP-70
    Names
    tyrosine-protein kinase ZAP-70
    syk-related tyrosine kinase
    70 kDa zeta-associated protein
    70 kDa zeta-chain associated protein
    zeta-chain associated protein kinase, 70kD
    NP_001070.2
    NP_997402.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007727.1 RefSeqGene

      Range
      5001..31293
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_126

    mRNA and Protein(s)

    1. NM_001079.3 → NP_001070.2  tyrosine-protein kinase ZAP-70 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      L05148
      Consensus CDS
      CCDS33254.1
      UniProtKB/Swiss-Prot
      P43403
      Related
      ENSP00000264972, OTTHUMP00000203013, ENST00000264972, OTTHUMT00000329278
      Conserved Domains (4) summary
      cd05115
      Location:342 – 598
      Blast Score: 1403
      PTKc_Zap-70; Catalytic domain of the Protein Tyrosine Kinase, Zeta-chain-associated protein of 70kDa
      cd09938
      Location:8 – 111
      Blast Score: 530
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10402
      Location:152 – 255
      Blast Score: 555
      SH2_C-SH2_Zap70; C-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70)
      pfam07714
      Location:338 – 593
      Blast Score: 918
      Pkinase_Tyr; Protein tyrosine kinase

    2. NM_207519.1 → NP_997402.1  tyrosine-protein kinase ZAP-70 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as TZK) differs in the 5' UTR and lacks several exons in the 5' coding region, compared to variant 1. The resulting isoform (2, also known as truncated ZAP kinase) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AB083211, L05148
      Consensus CDS
      CCDS33255.1
      UniProtKB/Swiss-Prot
      P43403
      Related
      ENSP00000400475, OTTHUMP00000216626, ENST00000451498, OTTHUMT00000353475
      Conserved Domains (2) summary
      cd05115
      Location:35 – 291
      Blast Score: 1365
      PTKc_Zap-70; Catalytic domain of the Protein Tyrosine Kinase, Zeta-chain-associated protein of 70kDa
      pfam07714
      Location:31 – 286
      Blast Score: 906
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000002.11 Reference GRCh37.p5 Primary Assembly

      Range
      98330031..98356323
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000134.1 Alternate HuRef

      Range
      92095689..92121947
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC016699.10 AAX93187.1
    genomic AC017099.11 (223948..228425) None
    genomic CH471127.2 EAX01918.1
      EAX01919.1
    mRNA AB083211.1 BAC43747.1
    mRNA AK303341.1 BAG64404.1
    mRNA AK310628.1 None
    mRNA AK310637.1 None
    mRNA AL832287.1 None
    mRNA BC039039.1 AAH39039.1
    mRNA BC053878.1 AAH53878.1
    mRNA L05148.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43403.1 GenPept UniProtKB/Swiss-Prot:P43403
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

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