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    ABL1 c-abl oncogene 1, non-receptor tyrosine kinase [ Homo sapiens ]

    Gene ID: 25, updated on 20-May-2012
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    Summary

    Official Symbol
    ABL1provided by HGNC
    Official Full Name
    c-abl oncogene 1, non-receptor tyrosine kinaseprovided by HGNC
    Primary source
    HGNC:76
    Locus tag
    RP11-83J21.1
    See related
    Ensembl:ENSG00000097007; HPRD:01809; MIM:189980; Vega:OTTHUMG00000020813
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ABL; JTK7; p150; c-ABL; v-abl; bcr/abl
    Summary
    The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    9q34.1
    Sequence :
    Chromosome: 9; NC_000009.11 (133589268..133763062)
    See ABL1 in Epigenomics, MapViewer

    Chromosome 9 - NC_000009.11Genomic Context describing neighboring genes Neighboring gene PR domain containing 12 Neighboring gene exosome component 2 Neighboring gene ribosomal protein L37 pseudogene 17 Neighboring gene pyroglutamylated RFamide peptide Neighboring gene fibrinogen C domain containing 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. The variant translocation of ABL1 gene t(2;9)(q21;q34) in a childhood T-cell acute lymphoblastic leukemia. Karkucak M, et al. Bratisl Lek Listy, 2012. PMID 22380496.
    2. Interaction of proliferation cell nuclear antigen (PCNA) with c-Abl in cell proliferation and response to DNA damages in breast cancer. Zhao H, et al. PLoS One, 2012. PMID 22238610.
    3. Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival. Hamilton A, et al. Blood, 2012 Feb 9. PMID 22184410.
    4. Fitness conferred by BCR-ABL kinase domain mutations determines the risk of pre-existing resistance in chronic myeloid leukemia. Leder K, et al. PLoS One, 2011. PMID 22140458.
    5. BCR-ABL mutations in chronic myeloid leukemia. Ernst T, et al. Hematol Oncol Clin North Am, 2011 Oct. PMID 22054731.

    See all (481) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. c-Abl facilitates chromatin association of PCNA and is required for nuclear foci formation of PCNA in cells stressed by DNA damage as well as in unperturbed cells.
      Title: Interaction of proliferation cell nuclear antigen (PCNA) with c-Abl in cell proliferation and response to DNA damages in breast cancer.
    2. Activation of transgenic c-Abl by amyloidbeta precursor protein promotes tau phosphorylation through Tyr15 phosphorylation-mediated cyclin-dependent protein kinase 5 (Cdk5) activation.
      Title: c-Abl tyrosine kinase modulates tau pathology and Cdk5 phosphorylation in AD transgenic mice.
    3. BCR-ABL mutations in chronic myeloid leukemia [review]
      Title: BCR-ABL mutations in chronic myeloid leukemia.
    4. c-Abl interconnecting Met-RTK and p53 core pathways, and its inhibition impairs Met-dependent tumorigenesis. Met ensures cell survival through a new path in which c-Abl and p38-MAPK are employed to elicit p53 phosphorylation and Mdm2 upregulation.
      Title: Abl interconnects oncogenic Met and p53 core pathways in cancer cells.
    5. The fitness changes (i.e., changes in net reproductive rate) conferred by BCR-ABL kinase domain mutations to the likelihood, composition, and diversity of pre-existing resistance, was investigated.
      Title: Fitness conferred by BCR-ABL kinase domain mutations determines the risk of pre-existing resistance in chronic myeloid leukemia.
    6. poor clinical course of the case may contribute to explanation of the action of t(9;22)(q34;q11) translocation
      Title: The variant translocation of ABL1 gene t(2;9)(q21;q34) in a childhood T-cell acute lymphoblastic leukemia.
    7. Data suggest that chronic myeloid leukemia stem cell survival is Bcr-Abl kinase independent and suggest curative approaches in CML must focus on kinase-independent mechanisms of resistance.
      Title: Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival.
    8. The phosphorylation and dephosphorylation cycle of VASP by the Abi-1-bridged mechanism regulates association of VASP with focal adhesions, which may regulate adhesion of Bcr-Abl-transformed leukaemic cells.
      Title: Abi-1-bridged tyrosine phosphorylation of VASP by Abelson kinase impairs association of VASP to focal adhesions and regulates leukaemic cell adhesion.
    9. Expression of nuclear-targeted c-Abl drastically increases the levels of chromatin structural changes.
      Title: Nuclear c-Abl-mediated tyrosine phosphorylation induces chromatin structural changes through histone modifications that include H4K16 hypoacetylation.
    10. mechanisms of allosteric activation may have universally evolved in the ABL and EGFR regulatory complexes as a product of a functional cross-talk between the organizing alphaF-helix and conformationally adaptive alphaI-helix and alphaC-helix
      Title: Computational modeling of allosteric communication reveals organizing principles of mutation-induced signaling in ABL and EGFR kinases.
    Submit: New GeneRIF Correction See all (275)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Leukemia, Philadelphia chromosome-positive, resistant to imatinib

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_005148.1 NP_058431.2 CRK    BIND  PubMed Interaction between ABL (PDB ID: 1JU5_C) and CRK (PDB ID: 1JU5_A). 
    NP_005148.1 CRK    BIND  PubMed c-Abl interacts with Crk. This interaction was modeled on a demonstrated interaction between human c-Abl and Crk from an unspecified species. 
    NP_005148.1 AAC00042.1 PDE4D    BIND  PubMed PDE4D4 interacts with Abl. This interaction was modelled on a demonstrated interaction between human PDE4D4 and abl from an unspecified species. 
    NP_005148.1 NP_000312.1 RB1    BIND  PubMed Rb interacts with c-Abl 
    NP_005148.1 NP_002932.1 ROBO1    BIND  PubMed Robo1 interacts with Abl1. This interaction was modelled on a demonstrated interaction between Robo1 from human and Abl1 from Drosophila melanogaster. 
    NP_005148.1 NP_003396.1 YWHAH    BIND  PubMed c-Abl interacts with 14-3-3-eta. 
    NP_005148.1 YWHAZ    BIND  PubMed c-Abl interacts with 14-3-3-delta. 
    NP_009297.1 NP_009297.1 ABL1    BIND  PubMed c-Abl 1b interacts with itself in trans via the SH2 domain. 
    NP_009297.1 NP_009298.1 ABL2    BIND  PubMed c-Abl interacts with ARG. 
    NP_009297.1 NP_004318.2 BCR    BIND  PubMed BCR interacts with c-Abl. This interaction was modeled on a demonstrated interaction between BCR from an unspecified source and human c-Abl. 
    NP_009297.1 NP_852664.1 PIK3R1    BIND  PubMed c-Abl interacts with p85. This interaction was modeled on a demonstrated interaction between human c-Abl and bovine p85. 
    NP_009297.1 NP_002651.2 PLCG1    BIND  PubMed c-Abl interacts with PLC-gamma1. This interaction was modeled on a demonstrated interaction between human c-Abl and bovine PLCgamma1. 
    NP_009297.1 NP_002881.1 RASA1    BIND  PubMed c-Abl interacts with GAP. 
    NP_009297.1 NP_005408.1 SRC    BIND  PubMed c-Abl interacts with Src. This interaction was modeled on a demonstrated interaction between human c-Abl and v-Src from the Rous Sarcoma virus. 
    NP_009297.1 NP_003922.1 WASF1    BIND  PubMed WAVE-1 interacts with Abl. 
    NP_009297.2 NP_009298.1 ABL2    BIND  PubMed ABL1 (c-Abl) phosphorylates ABL2 (Arg). 
    P00519 Q8IZP0 ABI1    HPRD  PubMed  
    P00519 Q9NYB9 ABI2    HPRD  PubMed  
    P00519 P00519 ABL1    HPRD  PubMed  
    P00519 P00519 ABL1    HPRD  PubMed  
    P00519 P42684 ABL2    HPRD  PubMed  
    P00519 P68133 ACTA1    HPRD  PubMed  
    P00519 Q13444 ADAM15    HPRD  PubMed  
    P00519 O00213 APBB1    HPRD  PubMed  
    P00519 P05067 APP    HPRD  PubMed  
    P00519 Q13315 ATM    HPRD  PubMed  
    P00519 P56945 BCAR1    HPRD  PubMed  
    P00519 P11274 BCR    HPRD  PubMed  
    P00519 O00499 BIN1    HPRD  PubMed  
    P00519 P38398 BRCA1    HPRD  PubMed  
    P00519 Q06187 BTK    HPRD  PubMed  
    P00519 P01024 C3    HPRD  PubMed  
    P00519 Q8TDN4 CABLES1    HPRD  PubMed  
    P00519 Q9BTV7 CABLES2    HPRD  PubMed  
    P00519 P55211 CASP9    HPRD  PubMed  
    P00519 P22681 CBL    HPRD  PubMed  
    P00519 P15391 CD19    HPRD  PubMed  
    P00519 P06493 CDK1    HPRD  PubMed  
    P00519 Q00535 CDK5    HPRD  PubMed  
    P00519 P46527 CDKN1B    HPRD  PubMed  
    P00519 P16220 CREB1    HPRD  PubMed  
    P00519 P46108 CRK    HPRD  PubMed  
    P00519 P46109 CRKL    HPRD  PubMed  
    P00519 Q9UQB3 CTNND2    HPRD  PubMed  
    P00519 Q16531 DDB1    HPRD  PubMed  
    P00519 Q92466 DDB2    HPRD  PubMed  
    P00519 Q99704 DOK1    HPRD  PubMed  
    P00519 O60496 DOK2    HPRD  PubMed  
    P00519 Q7L591 DOK3    HPRD  PubMed  
    P00519 Q8N8S7 ENAH    HPRD  PubMed  
    P00519 Q09472 EP300    HPRD  PubMed  
    P00519 P29323 EPHB2    HPRD  PubMed  
    P00519 Q9UI08 EVL    HPRD  PubMed  
    P00519 P07203 GPX1    HPRD  PubMed  
    P00519 P62993 GRB2    HPRD  PubMed  
    P00519 O15399 GRIN2D    HPRD  PubMed  
    P00519 P08631 HCK    HPRD  PubMed  
    P00519 SHIP2 INPPL1    HPRD  PubMed  
    P00519 P23458 JAK1    HPRD  PubMed  
    P00519 O60674 JAK2    HPRD  PubMed  
    P00519 P05412 JUN    HPRD  PubMed  
    P00519 P10721 KIT    HPRD  PubMed  
    P00519 Q92918 MAP4K1    HPRD  PubMed  
    P00519 Q9Y4K4 MAP4K5    HPRD  PubMed  
    P00519 P10636 MAPT    HPRD  PubMed  
    P00519 Q00987 MDM2    HPRD  PubMed  
    P00519 P15941 MUC1    HPRD  PubMed  
    P00519 P16333 NCK1    HPRD  PubMed  
    P00519 Q92542 NCSTN    HPRD  PubMed  
    P00519 Q14511 NEDD9    HPRD  PubMed  
    P00519 P04629 NTRK1    HPRD  PubMed  
    P00519 Q9NWQ8 PAG1    HPRD  PubMed  
    P00519 Q13177 PAK2    HPRD  PubMed  
    P00519 P27986 PIK3R1    HPRD  PubMed  
    P00519 P19174 PLCG1    HPRD  PubMed  
    P00519 O15162 PLSCR1    HPRD  PubMed  
    P00519 P24928 POLR2A    HPRD  PubMed  
    P00519 Q15139 PRKD1    HPRD  PubMed  
    P00519 P78527 PRKDC    HPRD  PubMed  
    P00519 O43586 PSTPIP1    HPRD  PubMed  
    P00519 Q05209 PTPN12    HPRD  PubMed  
    P00519 Q99952 PTPN18    HPRD  PubMed  
    P00519 P29350 PTPN6    HPRD  PubMed  
    P00519 P49023 PXN    HPRD  PubMed  
    P00519 Q06609 RAD51    HPRD  PubMed  
    P00519 P43351 RAD52    HPRD  PubMed  
    P00519 Q99638 RAD9A    HPRD  PubMed  
    P00519 P62826 RAN    HPRD  PubMed  
    P00519 P20936 RASA1    HPRD  PubMed  
    P00519 P06400 RB1    HPRD  PubMed  
    P00519 P22670 RFX1    HPRD  PubMed  
    P00519 Q13671 RIN1    HPRD  PubMed  
    P00519 Q9Y6N7 ROBO1    HPRD  PubMed  
    P00519 P08922 ROS1    HPRD  PubMed  
    P00519 P31947 SFN    HPRD  PubMed  
    P00519 P78314 SH3BP2    HPRD  PubMed  
    P00519 Q96IW2 SHD    HPRD  PubMed  
    P00519 Q5VZ18 SHE    HPRD  PubMed  
    P00519 Q9UBY0 SLC9A2    HPRD  PubMed  
    P00519 Q9BX66 SORBS1    HPRD  PubMed  
    P00519 Arg binding protein 2 SORBS2    HPRD  PubMed  
    P00519 O60504 SORBS3    HPRD  PubMed  
    P00519 Q07890 SOS2    HPRD  PubMed  
    P00519 P12931 SRC    HPRD  PubMed  
    P00519 P78524 ST5    HPRD  PubMed  
    P00519 O14746 TERT    HPRD  PubMed  
    P00519 P04637 TP53    HPRD  PubMed  
    P00519 O15350 TP73    HPRD  PubMed  
    P00519 Q9Y4K3 TRAF6    HPRD  PubMed  
    P00519 P50607 TUB    HPRD  PubMed  
    P00519 Q92558 WASF1    HPRD  PubMed  
    P00519 Q8IV90 WASF2    HPRD  PubMed  
    P00519 P12956 XRCC6    HPRD  PubMed  
    P00519 P46937 YAP1    HPRD  PubMed  
    P00519 Q96MU7 YTHDC1    HPRD  PubMed  
    P00519 P31946 YWHAB    HPRD  PubMed  
    P00519 P62258 YWHAE    HPRD  PubMed  
    P00519 P61981 YWHAG    HPRD  PubMed  
    P00519 Q04917 YWHAH    HPRD  PubMed  
    P00519 P27348 YWHAQ    HPRD  PubMed  
    P00519 P63104 YWHAZ    HPRD  PubMed  
    P00519 P43403 ZAP70    HPRD  PubMed  
    P00519 Q969W1 ZDHHC16    HPRD  PubMed  
    BAB55675.1 ABI1    BIND  PubMed hNap1BP interacts with Abl. 
    BioGRID:106543 BioGRID:115324 ABI1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106543 BioGRID:115454 ABI2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106543 BioGRID:106543 ABL1    BioGRID  PubMed Protein-peptide 
    BioGRID:106543 BioGRID:106545 ABL2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106543 BioGRID:120424 ARHGAP17    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106543 BioGRID:106962 ATM    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid 
    BioGRID:106543 BioGRID:107027 ATR    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Protein-peptide 
    BioGRID:106543 BioGRID:107049 BAG1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106543 BioGRID:114934 BCAR1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:106543 BioGRID:107083 BCR    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106543 BioGRID:107140 BRCA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106543 BioGRID:123628 CABLES2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106543 BioGRID:107297 CAT    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:106543 BioGRID:107315 CBL    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Far Western 
    BioGRID:106543 BioGRID:107775 CREB1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106543 BioGRID:107789 CRKL    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106543 BioGRID:198873 Creb1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106543 BioGRID:108131 DOK1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:106543 BioGRID:108356 EPHA3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106543 BioGRID:108362 EPHB2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106543 BioGRID:119556 EVL    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106543 BioGRID:109134 GPX1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106543 BioGRID:109144 GRB10    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106543 BioGRID:109142 GRB2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106543 BioGRID:201466 Grap2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106543 BioGRID:109305 HCK    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106543 BioGRID:109552 HSP90AA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106543 BioGRID:109540 HSPA4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106543 BioGRID:109544 HSPA8    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106543 BioGRID:109848 INPPL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106543 BioGRID:109919 JAK1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106543 BioGRID:200856 Jak1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106543 BioGRID:110358 MDM2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:106543 BioGRID:122290 MICAL1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106543 BioGRID:108757 MTOR    BioGRID  PubMed Affinity Capture-Western 
    NP_000256.1 NCF1C    BIND  PubMed c-Abl interacts with p47phox. 
    BioGRID:106543 BioGRID:110770 NCK1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106543 BioGRID:113841 NCOA3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106543 BioGRID:110811 NEDD4    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:106543 BioGRID:116915 NEDD4L    BioGRID  PubMed Biochemical Activity 
    BioGRID:106543 BioGRID:110816 NEDD9    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106543 BioGRID:110859 NFKBIA    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106543 BioGRID:110969 NTRK1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106543 BioGRID:247522 Nedd4    BioGRID  PubMed Biochemical Activity 
    BioGRID:106543 BioGRID:120931 PAG1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:106543 BioGRID:111098 PAK2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:106543 BioGRID:111105 PARK2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:106543 BioGRID:111142 PCNA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106543 BioGRID:111313 PIK3R1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106543 BioGRID:111351 PLCG1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106543 BioGRID:111577 PRKDC    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106543 BioGRID:114513 PSTPIP1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106543 BioGRID:111742 PTPN6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106543 BioGRID:111825 RAD51    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106543 BioGRID:111820 RAD9A    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:106543 BioGRID:111837 RAN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106543 BioGRID:111860 RB1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106543 BioGRID:111921 RFX1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    NP_004283.1 RIN1    BIND  PubMed ABL1 interacts with and phosphorylates RIN1. 
    BioGRID:106543 BioGRID:116997 RYBP    BioGRID  PubMed Far Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106543 BioGRID:117149 SH3BP1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106543 BioGRID:112361 SHC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106543 BioGRID:121283 SHD    BioGRID  PubMed Biochemical Activity; Two-hybrid 
    BioGRID:106543 BioGRID:126009 SHE    BioGRID  PubMed Two-hybrid 
    BioGRID:106543 BioGRID:112439 SLC9A2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106543 BioGRID:115831 SORBS1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106543 BioGRID:114047 SORBS2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:106543 BioGRID:112537 SOS1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106543 BioGRID:112586 SPTA1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106543 BioGRID:112587 SPTAN1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:106543 BioGRID:112592 SRC    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106543 BioGRID:112642 ST5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106543 BioGRID:112665 STK4    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:106543 BioGRID:115563 STUB1    BioGRID  PubMed Biochemical Activity 
    BioGRID:106543 BioGRID:112872 TERF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106543 BioGRID:116256 TOPBP1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:106543 BioGRID:113010 TP53    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106543 BioGRID:113014 TP73    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106543 BioGRID:113126 TUB    BioGRID  PubMed Biochemical Activity 
    BioGRID:106543 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106543 BioGRID:113252 VAV1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid 
    BioGRID:106543 BioGRID:108822 XRCC6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106543 BioGRID:124871 YTHDC1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:106543 BioGRID:113367 ZAP70    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106543 BioGRID:124014 ZDHHC16    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem"Integrins are cell surface heterodimeric protein complex consisting of one alpha and one beta chain. Integrins act as cell adhesion molecules as well as participate in cellular signaling. The ligand...
    • Axon guidance, organism-specific biosystem (from KEGG)
      Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, conserved biosystem (from KEGG)
      Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • CDO in myogenesis, organism-specific biosystem (from REACTOME)
      CDO in myogenesis, organism-specific biosystemCDO/Cdon (cell-adhesion-molecule-related/downregulated by oncogenes) is a type I transmembrane multifunctional co-receptor consisting of five immunoglobulin and three fibronectin type III (FNIII) rep...
    • Cell cycle, organism-specific biosystem (from WikiPathways)
      Cell cycle, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Chronic myeloid leukemia, organism-specific biosystem (from KEGG)
      Chronic myeloid leukemia, organism-specific biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
    • Chronic myeloid leukemia, conserved biosystem (from KEGG)
      Chronic myeloid leukemia, conserved biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • ErbB signaling pathway, organism-specific biosystem (from WikiPathways)
      ErbB signaling pathway, organism-specific biosystemThe ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with ...
    • ErbB signaling pathway, organism-specific biosystem (from KEGG)
      ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • ErbB signaling pathway, conserved biosystem (from KEGG)
      ErbB signaling pathway, conserved biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
      Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Kit Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Kit Receptor Signaling Pathway, organism-specific biosystemKit is a receptor protein tyrosine kinase, which is a receptor for stem cell factor or kit ligand. Signaling through Kit is important for formation of red cells, lymphocytes, mast cells and platelets...
    • Lissencephaly gene (LIS1) in neuronal migration and development, organism-specific biosystem (from Pathway Interaction Database)
      Lissencephaly gene (LIS1) in neuronal migration and development, organism-specific biosystem
      Lissencephaly gene (LIS1) in neuronal migration and development
    • Myogenesis, organism-specific biosystem (from REACTOME)
      Myogenesis, organism-specific biosystemMyogenesis, the formation of muscle tissue, is a complex process involving steps of cell proliferation mediated by growth factor signaling, cell differentiation, reorganization of cells to form myotu...
    • Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
      Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem
      Neurotrophic factor-mediated Trk receptor signaling
    • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
      Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
      Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • PDGFR-beta signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      PDGFR-beta signaling pathway, organism-specific biosystem
      PDGFR-beta signaling pathway
    • Pathogenic Escherichia coli infection, organism-specific biosystem (from KEGG)
      Pathogenic Escherichia coli infection, organism-specific biosystemEnteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction o...
    • Pathogenic Escherichia coli infection, conserved biosystem (from KEGG)
      Pathogenic Escherichia coli infection, conserved biosystemEnteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction o...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Regulation of Telomerase, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of Telomerase, organism-specific biosystem
      Regulation of Telomerase
    • Regulation of retinoblastoma protein, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of retinoblastoma protein, organism-specific biosystem
      Regulation of retinoblastoma protein
    • Role of Abl in Robo-Slit signaling, organism-specific biosystem (from REACTOME)
      Role of Abl in Robo-Slit signaling, organism-specific biosystemAbl plays a dual role in the Robo pathway. As a key enzymatic component in the signaling pathway, Abl support repellent signaling (by recruiting the necessary actin binding proteins) and also feed ba...
    • Shigellosis, organism-specific biosystem (from KEGG)
      Shigellosis, organism-specific biosystemShigellosis, or bacillary dysentery, is an intestinal infection caused by Shigella, a genus of enterobacteria. Shigella are potential food-borne pathogens that are capable of colonizing the intestina...
    • Signaling by Robo receptor, organism-specific biosystem (from REACTOME)
      Signaling by Robo receptor, organism-specific biosystemThe Roundabout (Robo) family encodes transmembrane receptors that regulate axonal guidance and cell migration. The major function of the Robo receptors is to mediate repulsion of the navigating growt...
    • T Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      T Cell Receptor Signaling Pathway, organism-specific biosystem
      T Cell Receptor Signaling Pathway
    • TP53 network, organism-specific biosystem (from WikiPathways)
      TP53 network, organism-specific biosystemP53 is not a lonely genome guardian, it operates with the assistance of p73 and p63 within a complex network including distinct but complementary pathways. This protein family presents a high le...
    • Viral myocarditis, organism-specific biosystem (from KEGG)
      Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...
    • miRNAs involved in DDR, organism-specific biosystem (from WikiPathways)
      miRNAs involved in DDR, organism-specific biosystemMicroRNA clusters involved in de DNA damage response. Genes they regulated and genes that regulate them. All genes presented in this pathway can also be found in the pathway "DNA damage response(Homo...
    • p53 pathway, organism-specific biosystem (from Pathway Interaction Database)
      p53 pathway, organism-specific biosystem
      p53 pathway

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    DNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    SH3 domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    actin monomer binding TAS
    Traceable Author Statement
    more info
    		  
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    manganese ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mitogen-activated protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    nicotinate-nucleotide adenylyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    non-membrane spanning protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    proline-rich region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    DNA damage induced protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    DNA damage response, signal transduction resulting in induction of apoptosis TAS
    Traceable Author Statement
    more info
    		  
    actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    axon guidance TAS
    Traceable Author Statement
    more info
    		  
    blood coagulation TAS
    Traceable Author Statement
    more info
    		  
    mismatch repair TAS
    Traceable Author Statement
    more info
    		 PubMed 
    muscle cell differentiation TAS
    Traceable Author Statement
    more info
    		  
    negative regulation of protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of muscle cell differentiation TAS
    Traceable Author Statement
    more info
    		  
    positive regulation of oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein modification process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    regulation of actin cytoskeleton reorganization TAS
    Traceable Author Statement
    more info
    		  
    regulation of autophagy TAS
    Traceable Author Statement
    more info
    		  
    regulation of cell adhesion TAS
    Traceable Author Statement
    more info
    		  
    regulation of cell motility TAS
    Traceable Author Statement
    more info
    		  
    regulation of endocytosis TAS
    Traceable Author Statement
    more info
    		  
    regulation of response to DNA damage stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of transcription involved in S phase of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of transcription, DNA-dependent TAS
    Traceable Author Statement
    more info
    		 PubMed 
    signal transduction in response to DNA damage IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    actin cytoskeleton TAS
    Traceable Author Statement
    more info
    		  
    cytoplasm TAS
    Traceable Author Statement
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    nucleus TAS
    Traceable Author Statement
    more info
    		  
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Help top of page

    General protein information

    Preferred Names
    tyrosine-protein kinase ABL1
    Names
    tyrosine-protein kinase ABL1
    proto-oncogene c-Abl
    bcr/c-abl oncogene protein
    Abelson tyrosine-protein kinase 1
    c-abl oncogene 1, receptor tyrosine kinase
    proto-oncogene tyrosine-protein kinase ABL1
    v-abl Abelson murine leukemia viral oncogene homolog 1
    NP_005148.2
    NP_009297.2
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012034.1 RefSeqGene

      Range
      5001..178795
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005157.4 → NP_005148.2  tyrosine-protein kinase ABL1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (a) includes exon 1a, but not exon 1b, resulting in a different N-terminus. This variant is localized in the nucleus.
      Source sequence(s)
      AA524892, AB209456, M14752
      Consensus CDS
      CCDS35166.1
      UniProtKB/Swiss-Prot
      P00519
      UniProtKB/TrEMBL
      Q59FK4
      Related
      ENSP00000323315, OTTHUMP00000022375, ENST00000318560, OTTHUMT00000054684
      Conserved Domains (5) summary
      cd00174
      Location:66 – 118
      Blast Score: 149
      SH3; Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of ...
      cd05052
      Location:235 – 497
      Blast Score: 1435
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      cd09935
      Location:123 – 216
      Blast Score: 500
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cl07494
      Location:953 – 1130
      Blast Score: 694
      F_actin_bind; F-actin binding
      pfam07714
      Location:242 – 493
      Blast Score: 1038
      Pkinase_Tyr; Protein tyrosine kinase

    2. NM_007313.2 → NP_009297.2  tyrosine-protein kinase ABL1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (b) includes exon 1b, but not exon 1a, resulting in a different N-terminus. This variant contains an N-terminal glycine which could be myristylated and is thus postulated to be directed to the plasma membrane.
      Source sequence(s)
      AA524892, AB209456, AL707819, CA335983
      Consensus CDS
      CCDS35165.1
      UniProtKB/Swiss-Prot
      P00519
      UniProtKB/TrEMBL
      Q59FK4
      Related
      ENSP00000361423, OTTHUMP00000022376, ENST00000372348, OTTHUMT00000054685
      Conserved Domains (5) summary
      cd00174
      Location:85 – 137
      Blast Score: 149
      SH3; Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of ...
      cd05052
      Location:254 – 516
      Blast Score: 1438
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      cd09935
      Location:142 – 235
      Blast Score: 499
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cl07494
      Location:972 – 1149
      Blast Score: 694
      F_actin_bind; F-actin binding
      pfam07714
      Location:261 – 512
      Blast Score: 1039
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000009.11 Reference GRCh37.p5 Primary Assembly

      Range
      133589268..133763062
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000141.1 Alternate HuRef

      Range
      103075969..103249725
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL161733.20 CAM45754.1
      CAM45755.1
      CAM45756.1
    genomic AL161733.20 CAM45754.1
      CAM45755.1
      CAM45756.1
    genomic AL359092.14 CAM45752.1
    genomic CH471090.1 EAW87947.1
      EAW87948.1
      EAW87949.1
    genomic DQ145721.1 AAZ38718.1
    genomic K00009.1 AAA51895.1
    genomic M25949.1 AAA35593.1
    genomic S69223.1 AAD14034.1
    genomic U07563.1 AAB60393.1
      AAB60394.1
    mRNA AA524892.1 None
    mRNA AB209456.1 BAD92693.1
    mRNA AB209642.1 BAD92879.1
    mRNA AF113911.1 AAD04633.1
    mRNA AJ131466.1 CAA10376.1
    mRNA AK294983.1 BAG58052.1
    mRNA AL707819.1 None
    mRNA BC107069.1 AAI07070.1
    mRNA BC107070.1 AAI07071.1
    mRNA BC117451.1 AAI17452.1
    mRNA CA335983.1 None
    mRNA M14752.1 AAA51561.1
    mRNA M14753.1 AAA51562.1
    mRNA M14754.1 AAA51563.1
    mRNA M25946.1 AAA35697.1
    mRNA M30833.1 AAA88011.1
      AAA88012.1
    mRNA X16416.1 CAA34438.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00519.4 GenPept UniProtKB/Swiss-Prot:P00519
    Q13688 GenPept UniProtKB/TrEMBL:Q13688
    Q13689 GenPept UniProtKB/TrEMBL:Q13689
    Q13690 GenPept UniProtKB/TrEMBL:Q13690
    Q13691 GenPept UniProtKB/TrEMBL:Q13691
    Q13848 GenPept UniProtKB/TrEMBL:Q13848
    Q13914 GenPept UniProtKB/TrEMBL:Q13914
    Q13915 GenPept UniProtKB/TrEMBL:Q13915
    Q14020 GenPept UniProtKB/TrEMBL:Q14020
    Q3B836 GenPept UniProtKB/TrEMBL:Q3B836
    Q3B837 GenPept UniProtKB/TrEMBL:Q3B837
    Q59F19 GenPept UniProtKB/TrEMBL:Q59F19
    Q59FK4 GenPept UniProtKB/TrEMBL:Q59FK4
    Help top of page

    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
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    Tools
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